Professor Mark Little
Professor of Nephrology and Researcher, Trinity Translational Medicine Institute
- Research Institute:
Trinity Translational Medicine Institute
- Contact e-mail:
- Contact number:
- Thematic Area:
Translational Immunology Studies
Research Profile:
Research interests include investigating ANCA vasculitis pathogenesis, biomarker development and application of data science techniques to study autoimmunity and its interaction with covid-19. He leads the HELICAL and FAIRVASC EU consortia, is co-founder and coordinator of ERN-RITA, rare immune disorders European Reference Network, lead of the European Vasculitis Society Registry initiative, chair of Vasculitis Ireland Network and co-founder/co-chair of UKIVAS, (vasculitis society of UK and Ireland).
COVID-19 Project:
We wish to investigate the phenotype and function of specific neutrophil populations at different time points in the evolution of COVID-19 disease, and to explore the interaction between these cells and innate T-cell populations. We will focus primarily on patients with systemic autoimmune disease in receipt of immunomodulating therapies (before acquiring COVID-19) in order to define the impact of these therapies on the disease course and evolving immunophenotype.
