Selected Publications
Pollock JK, Greene LM, Nathwani SM, Kinsella P, O'Boyle NM, Meegan MJ, Zisterer DM. (2018) Involvement of NF-kB in mediating the anti-tumour effects of combretastatins in T cells. Invest New Drugs. In press
O'Boyle NM, Barrett I, Greene LM, Carr M, Fayne D, Twamley B, Knox AJS, Keely NO, Zisterer DM, Meegan MJ. (2018) Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERa and ERb Activity. J Med Chem. 25;61(2):514-534
Geoghegan F, Chadderton N, Farrar GJ, Zisterer DM, Porter RK. (2017) Direct effects of phenformin on metabolism/bioenergetics and viability of SH-SY5Y neuroblastoma cells. Oncol Lett. 14(5):6298-6306.
Kelly PM, Keely NO, Bright SA, Yassin B, Ana G, Fayne D, Zisterer DM, Meegan MJ. (2017) Novel Selective Estrogen Receptor Ligand Conjugates Incorporating Endoxifen Combretastatin and Cyclofenil-Combretastatin Hybrid Scaffolds: Synthesis and Biochemical Evaluation. Molecules. 22(9)
Malebari AM, Greene LM, Nathwani SM, Fayne D, O'Boyle NM, Wang S, Twamley B, Zisterer DM, Meegan MJ. (2017) b-Lactam analogues of combretastatin A-4 prevent metabolic inactivation by glucuronidation in chemoresistant HT-29 colon cancer cells. Eur J Med Chem. 130:261-285.
Meegan MJ, Nathwani S, Twamley B, Zisterer DM, O'Boyle NM. (2017) Piperlongumine (piplartine) and analogues: Antiproliferative microtubule-destabilising agents. Eur. J. Med. Chem. 125, 453-463.
Greene LM, Butini S, Campiani G, Williams DC, Zisterer DM. (2016) Pre-clinical evaluation of a novel class of anti-cancer agents-the Pyrrolo-1,5-benzoxazepines. J Cancer 7, 2367-2377.
Greene LM, Nathwani SM, Zisterer DM. (2016) Inhibition of γ-secretase activity synergistically enhances tumour necrosis factor-related apoptosis-inducing ligand induced apoptsis in T-cell acute lymphoblastic leukemia cells via upregulation of death receptor 5. Oncol. Lett. 12, 2900-2905.
Kelly PM, Bright SA, Fayne D, Pollock JK, Zisterer DM, Williams DC, Meegan MJ. (2016) Synthesis, antiproliferative and pro-apoptotic activity of 2-phenylindoles. Bioorg Med Chem. 24, 4075-99
Carr M, Knox AJ, Lloyd DG, Zisterer DM, Meegan MJ. (2016) Development of the beta-lactam type molecular scaffold for selective estrogen receptor alpha modulator action: synthesis and cytotoxic effects in MCF-7 breast cancer cells. J. Enzyme Inhib. Med Chem. 31, 117-130
Lennon JC, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM. (2016) Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells. Invest New Drugs. 43, 663-76.
Nathwani SM, Greene LM, Butini S, Campiani G, Williams DC, Samali A, Szegezdi E, Zisterer DM. (2016) The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL-induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells. Int J Oncol. 49, 74-88.
Brindisi M, Maramai S, Brogi S, Fanigliulo E, Butini S, Guarino E, Casagni A, Lamponi S, Bonechi C, Nathwani SM, Finetti F, Ragonese F, Arcidiacono P, Campiglia P, Valenti S, Novellino E, Spaccapelo R, Morbidelli L, Zisterer DM, Williams CD, Donati A, Baldari C, Campiani G, Ulivieri C, Gemma S. (2016) Development of novel cyclic peptides as pro-apoptotic agents. Eur J Med Chem. 117, 301-20
Kahvedžić-Seljubac A, Nathwani SM, Zisterer DM, Rozas I. (2016) Isouronium and N-hydroxyguanidinium derivatives as cell growth inhibitors: A comparative study. Eur J Med Chem. 117, 269-82.
Kinsella P, Greene LM, Bright SA, Pollock JK, Butini S, Campiani G, Bauer S, Williams DC, Zisterer DM. (2016) The novel pyrrolo-1,5-benzoxazepine, PBOX-15, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours; suggested mechanism of action of PBOX-15. Invest. New. Drugs. 34, 159-67.
Greene TF, Wang S, Greene LM, Nathwani SM, Pollock JK, Malebari AM, McCabe T, Twamley B, O'Boyle NM, Zisterer DM, Meegan MJ (2016) Synthesis and Biochemical Evaluation of 3-Phenoxy-1,4-diarylazetidin-2-ones as Tubulin-Targeting Antitumor Agents. J. Med. Chem. 14, 90-113.
Fiore D, Proto MC, Pisanti S, Picardi P, Pagano Zottola AC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Williams DC, Campiani G, Gazzerro P, Bifulco M. (2016) Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells. Cancer Biol Ther. 17,849-58.
Greene LM, Meegan MJ, Zisterer DM (2015) Combretastatins: More Than Just Vascular Targeting Agents? J. Pharmacol. Exp. Ther. 355, 212-27.
Spallarossa A, Caneva C, Caviglia M, Alfei S, Butini S, Campiani G, Gemma S, Brindisi M, Zisterer DM, Bright SA, Williams CD, Crespan E, Maga G, Sanna G, Delogu I, Collu G, Loddo R. (2015) Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents. Eur. J. Med. Chem. 102, 648-60.
O'Callaghan K, Palagano E, Butini S, Campiani G, Williams DC, Zisterer DM, O'Sullivan J. (2015) Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines Mol Med Rep. 12, 3748-54.
Pollock JK, Verma NK, O'Boyle NM, Carr M, Meegan MJ, Zisterer DM. (2014) Combretastatin (CA)-4 and its novel analogue CA-432 impair T-cell migration through the Rho/ROCK signalling pathway. Biochem. Pharmacol. 92, 544-57.
O'Boyle NM, Pollock JK, Carr M, Knox AJ, Nathwani SM, Wang S, Caboni L, Zisterer DM, Meegan MJ. (2014) b-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand. J. Med. Chem. 81,427-41.
Lennon, J.C, Bright, S.A., Carroll, E., Butini, S., Campiani, G. O'Meara, A., Williams D.C. and Zisterer, D.M. (2014) The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells. Biochem. Pharmacol. 8, 611-24.
Diez-Cecilia, E., Kelly, B., Perez, C., Zisterer, D.M., Nevin, D.K., Lloyd, D.G., Rozas, I. (2014) Guanidinium-based derivatives: searching for new kinase inhibitors. Eur. J. Med. Chem. 81,427-41.
Greene, L.M., Nolan, D.P., Regan-Komito, D., Campiani, G., Williams D.C. and Zisterer, D.M. (2013) Inhibition of late-stage autophagy synergistically enhances pyrrolo-1,5-benzoxazepine-6-induced apoptotic cell death in human colon cancer cells. Int. J. Oncol. 43, 927-35.
Greene, L.M., Wang, S., O'Boyle, N.M., Bright, S.A., Reid, J.E., Kelly, P., Meegan, M.J. and Zisterer, D.M. (2013) Combretazet-3 a novel synthetic cis-stable combretastatin-A4-azetidinone hybrid with enhanced stability and therapeutic efficacy in colon cancer Oncol Rep. 29, 2451-8.
O'Boyle N.M., Greene, L.M., Keely, N.O., Shu Wang., Cotter, T.S., Zisterer, D.M. and Meegan, M.J. (2013) Synthesis and biochemical activities of antiproliferative amino acid and phosphate derivatives of microtubule-disrupting beta-lactam combretastatins. Eur. J. Med. Chem. 62,705-721.
Kahvedžić, A., Nathwani, S.M., Zisterer, D.M. and Rozas, I. (2013) Aromatic Bis-Hydroxyguanidinium Derivatives: Synthesis, Biophysical and Biochemical Evaluations J. Med Chem. 56(2):451-9.
Nathwani SM, Hughes L, Greene LM, Carr M, O'Boyle NM, McDonnell S, Meegan MJ, Zisterer DM. (2013) Novel cis-restricted b-lactam combretastatin A-4 analogues display anti-vascular and anti-metastatic properties in vitro. Oncol Rep. 29(2):585-94.
Lysaght J, Verma NK, Maginn EN, Ryan JM, Campiani G, Zisterer DM, Williams DC, Browne PV, Lawler MP, McElligott AM. (2013) The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells. Int J Oncol. 42(1):239-46.
Greene LM, O'Boyle NM, Nolan DP, Meegan MJ, Zisterer DM. (2012) The vascular targeting agent Combretastatin-A4 directly induces autophagy in adenocarcinoma-derived colon cancer cells. Biochem Pharmacol. 84(5):612-24.
Zisterer, D.M., (2011) Treatment of chronic myeloid leukaemia: Current practice and future prospects in Myeloid Leukaemia/Book 2 (Koschmieder, ed)
O'Boyle N.M., Knox A.J., Price TT, Williams DC, Zisterer D.M., Lloyd D.G., Meegan M.J. (2011) Lead identification of beta-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90. Bioorg Med. Chem. 19, 6055-68.
O'Boyle N.M., Carr M., Greene L.M., Keely N.O., Knox A.J., McCabe T, Lloyd D.G., Zisterer D.M., Meegan M.J. (2011) Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe. Eur. J. Med. Chem. 46(9), 4595-607.
O'Boyle N.M., Greene L.M., Bergin O, Fichet JB, McCabe T, Lloyd D.G., Zisterer D.M., Meegan M.J. (2011) Synthesis, evaluation and structural studies of antiproliferative tubulin-targeting azetidin-2-ones. Bioorg. Med. Chem. 19, 2306-25.
Greene L.M., Carr M., Keeley N.O., Lawler M., Meegan M.J., Zisterer D.M. (2011) BubR1 is required for the mitotic block induced by combretastatin-A4 and a novel cis-restricted b-lactam analogue in human cancer cells. Int. J. Mol. Med. 27(5),715-23.
Butini S, Gemma S, Brindisi M, Borrelli G, Lossani A, Ponte AM, Torti A, Maga G, Marinelli L, La Pietra V, Fiorini I, Lamponi S, Campiani G, Zisterer DM, Nathwani SM, Sartini S, La Motta C, Da Settimo F, Novellino E, Focher F. (2011) Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modelling and biological studies. J. Med Chem. 54, 1401-20.
Maginn, E.N., Browne, P.V., Hayden, P., Vandenberghe, E., MacDonagh, B., Evans, P., Goodyer, M., Tewari, P., Campiani, G., Butini, S., Williams, D.C., Zisterer, D.M., Lawler, M.P., McElligott, A.M. (2011) PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells. Br. J. Cancer 104 (2):281-9.
O'Boyle N.M., Carr M, Greene L.M., Nathwani SM, McCabe T, Lloyd D.G., Zisterer D.M., Meegan M.J. (2010) Synthesis and evaluation of azetidinone analogues of combretatatin A-4 as tubulin targeting agents. J Med. Chem. 53, 8569-84.
Carr, M., Greene, L.M., Knox, A.J., Lloyd, D.G., Zisterer, D.M., Meegan, M.J. (2010) Lead identification of conformationally restricted ß-lactam type combretastatin analogues: Synthesis, antiproliferative activity and tubulin targeting effects. Eur. J. Med. Chem. In press
Greene LM, Nathwani SM, Bright SA, Fayne D, Croke A, Gargliardi M, Mc Elligott AM, O'Connor L, Carr M, Keely NO, O'Boyle NM, Carroll P, Sarkadi B, Conneally E, Lloyd DG, Lawler M, Meegan MJ & Zisterer DM. (2010) The vascular targeting agent Combretastatin-A4 and a novel cis-restricted {beta}-lactam analogue CA-432 induce apoptosis in human chronic myeloid leukemia cells and in ex vivo patient samples including those displaying multidrug resistance. J. Pharmacol. Exp. Ther. 335, 302-313.
Nathwani, S.M., Cloonan, S.M., Stronach, M., Campiani, G., Lawler, M., Williams, D.C. and Zisterer D.M. (2010) Novel microtubule targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells. Oncol. Rep. 24,1499-1507.
Barrett, I., Carr, M., O'Boyle, N., Greene, L.M., Knox, A.J., Lloyd, D.G. Zisterer, D.M. & Meegan, M.J. (2010) Lead identification of conformationally restricted benzoxepin type combretastatin analogs synthesis, antiproliferative activity and tubulin effects. J. Enz. Inhib. Med Chem.25, 180-194.
Bright, S.A., McElligott, A.M., O'Connell, J.W., O'Connor, L., Carroll, P., Deininger, M.W., Campiani, G., Lawler, M., Conneally, E., Williams, D.C., Zisterer, D.M. (2010) Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo. Brit J Can 102, 1474-1482.
Bright, S.A., Campiani, G., Deininger, M.W., Lawler, M., Williams, D.C., Zisterer, D.M. (2010) Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment. Biochem. Pharmacol.80, 31-38.
Nathwani SM, Butler S, Fayne, D., McGovern, N., Sarkadi, B., Meegan MJ, Lloyd, D.G., Campiani G, Lawler M, Williams DC, Zisterer DM (2010) Novel microtubule targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug resistant (MDR) cancer cells. Cancer Chemother Pharmacol 66, 585-596.
Nathwani SM, Butler S, Meegan MJ, Campiani G, Lawler M, Williams DC, Zisterer DM (2010) Dual targeting of tumour cells and host endothelial cells by novel microtubule targeting agents, pyrrolo-1,5-benzoxazepines. Cancer Chemother Pharmacol 65, 289-300.
McElligott A.M., Maginn, E.N., Greene, L.M. McGuckin, S., Hayat, A., Browne, P.V., Butini, S., Campiani, G., Catherwood, M.A., Vandenberghe, E., Williams, D.C., Zisterer, D.M. & Lawler, M. (2009) The novel tubulin targeting, pyrrolo-1,5-benzoxazepine-15, induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukaemia. Can. Res.69, 8366-75.
Bane FT, Pennington SR, Campiani G, Williams DC, Zisterer DM, Mc Gee MM (2009) The microtubule-targeting agents, PBOX-6 [pyrrolobenzoxazepine 7-[(dimethylcarbamoyl)oxy]-6-(2- naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine] and paclitaxel, induce nucleocytoplasmic redistribution of the peptidyl-prolyl isomerases, cyclophilin A and pin1, in malignant hematopoietic cells. (2009) J Pharmacol Exp Ther 329, 38-47
Bright S.A., Greene, L.M., Greene, T.F., Campiani, G., Buitini, S., Brindisi, M., Lawler, M., Meegan, M.J., Williams, D.C. and Zisterer, D.M. The novel pyrrolo-1,5-benzoxazepine, PBOX-21, synergistically enhances the apoptotic efficacy of STI-571 (Imatinib Mesylate) in human chronic myeloid leukaemia cells (2009) Biochem Pharmacol.77, 310-321.
Barrett, I., Meegan, M.J., Hughes, R.B., Carr, M., Knox, A.J.S. Artemenko, N., Golfis, G., Zisterer, D.M. & Lloyd, D.G. (2008) Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators. Bioinorg. Med. Chem.16, 9554-73
Meegan, M.J., Carr, M., Knox, A.J.S., Zisterer, D.M . & Lloyd, D.G. b -Lactam type molecular scaffolds for antiproliferative activity: Synthesis and cytotoxic effects in breast cancer cells. (2008) J. Enz. Inhib. Med Chem.5, 668-685.
Greene, L.M., Campiani, G., Lawler, M., Williams, D.C. & Zisterer, D.M . (2008) BubR1 is required for sustained mitotic spindle checkpoint arrest in human cancer cells treated with tubulin-targeting pyrrolo-1,5-benzoxazepines. Mol. Pharmacol. 73, 419-430.
Verma N.K., Dempsey, E., Conroy, J., Olwell, P., McElligott, A.M., Davies, A.M., Kelleher, D., Butini, S., Campiani, G., Williams, D.C., Zisterer, D.M., Lawler, M., & Volkov, Y. (2008) A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin. J. Mol. Med.86, 457-469.
Knox AJ, Meegan, MJ, Sobolev, V., Frost, D., Zisterer, D.M ., Williams, D.C., Lloyd, DG. (2007) Target specific virtual screening: optimization of an estrogen receptor screening platform. J. Med. Chem. 50, 5301-5310.
Meegan, M.J., Barrett, I., Zimmermann, J., Knox, A.J.S., Zisterer, D.M. & Lloyd, D.G. (2007) Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells. J. Enz. Inhib. Med Chem.22, 655-666.
Greene, L.M., Kelly, L., Onnis, V., Campiani, G., Lawler, M., Williams, D.C. & Zisterer, D.M. (2007) STI-571 enhances the apoptotic efficacy of PBOX-6, a novel microtubule targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl positive human chronic myeloid leukemia cells. J. Pharmacol. Exp. Ther. 321, 288-297.
Smith, H.M., Knox, A.S., Zisterer, D.M., Lloyd, D.G., & Meegan, M.J. (2007) Flexible estrogen receptor modulators: Synthesis, biochemistry and molecular modeling studies for 3-Benzyl-4,6-diarylhex-3-enes and 3,4,6-Triarylhex-3-enes Med Chem. 3, 135-155.
McGrath, L.B., Onnis, V., Campiani, G., Williams, D.C., Zisterer, D.M. & Mc Gee M.M. (2006) Caspase-activated DNase (CAD)-independent oligonucleosomal DNA fragmentation in chronic myeloid leukaemia cells; a requirement for serine protease and Mn 2+-dependent acidic endonuclease activity. Apoptosis 11, 1473-1487.
Mulligan, J., Greene, L.M., Cloonan, S., McGee, M.M., Onnis, V., Campiani, G., Nacci, V., Lawler, M., Williams, D.C., Zisterer, D.M. (2006) Identification of tubulin as the molecular target of pro-apoptotic pyrrolo-1,5-benzoxazepines. Mol. Pharmacol. 70,60-70.
Lloyd, D.G., Smith, H.M., O’Sullivan, T., Knox, A.S., Zisterer, D.M. & Meegan, M.J. (2006) Antiestrogenically active 2-benzyl-1,1-diarylbut-2-enes : Synthesis, Structure-Activity Relationships and Molecular Modeling Study for Flexible Estrogen Receptor Antagonists Med Chem. 2 (2), 147-168.
Greene, L.M. Fleeton, M., Mulligan, J., Chikanna, G., Sheahan, B.J., Atkins, G.J., Campiani, G., Nacci, V., Lawler, M., Williams, D.C., and Zisterer, D.M. (2005) The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status, and inhibits breast tumour growth in vivo. Oncology Reports. 14, 1357-1363
Lloyd, D.G., Smith, H.M., O'Sullivan, T., Knox, A.S., Zisterer, D.M. & Meegan, M.J. (2005) Synthesis, structure-activity relationships and antagonistic effects in human MCF-7 breast cancer cells of flexible estrogen receptor modulators. Med Chem. 1 (4), 335-353.
Mc Gee MM, Gemma S, Butini S, Ramunno A, Zisterer DM, Fattorusso C, Catalanotti B, Kukreja G, Fiorini I, Pisano C, Cucco C, Novellino E, Nacci V, Williams DC, Campiani G. (2005) Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target. J. Med. Chem. 48, 4367-4377.
McGee M., Greene, M., Ledwidge, S., Campiani, G., Nacci, V., Lawler, M., Williams, D.C. and Zisterer, D.M. (2004) Selective induction of apoptosis by PBOX-6 in leukaemia cells occurs via JNK dependent phosphorylation and inactivation of Bcl-2 and Bcl-Xl. J. Pharmacol. Exp. Ther. 310, 1084-95.
Mulligan J.M., Campiani G., Ramunno A., Nacci V., Zisterer D.M. (2003) Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human astrocytoma cells by pyrrolo-1,5-benzoxazepine, PBOX-21. Biochim Biophys Acta 1639, 43-52.
McGee M, Campiani, G. Ramunno, A., Nacci, V., Lawler, M. Williams, D.C & Zisterer, D.M. (2002) Activation of the c-Jun NH 2 terminal kinase (JNK) signalling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukaemia (CML) cells J. Biol. Chem. 515, 66-70.
McGee M, Hyland, E., Campiani, G. Ramunno, A., Nacci, V. & Zisterer, D.M. (2002) Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6. FEBS Letts515, 66-70.
Quinlan, C.A. , O'Sullivan, M.I., Zisterer, D.M. & Tipton, K.F. (2002) A study of the in vitro cytotoxicity of a composite resin and compomer Int. Endodontic. J. 35, 47-55.
Campiani, G., Ramunno, A., Fiorini, I., Nacci, V., Morelli, E., Novellino, E., Menninni, T., Zisterer, D.M., Williams, D.C. (2002) Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral-type benzodiazepine receptors (PBR). J.Med. Chem. 45, 4276-4281.
McGee, M., Campiani, G., Ramunno, A., Fattorusso, C., Nacci, V., Lawler, M., Williams, D.C., & Zisterer, D.M. (2001) Pyrrolo-1,5-benzoxazepines induce apoptosis in CML cells by bypassing the apoptotic suppressor Bcr-Abl. J. Pharmacol. Exp. Ther. 296, 31-40.
Meegan, M., Hughes, R., Lloyd, D.G., Zisterer, D.M. & Williams, D.C. Flexible estrogen receptor modulators: design, synthesis and antagonistic effects in human MCF-7 breast cancer cells. (2001) J. Med. Chem. 44, 1072-1084.
Zisterer, D.M., McGee M, Campiani, G. Ramunno, A., Fattorusso, C., Nacci, V., Lawler, M. & Williams (2001) Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents. Biochem. Soc Trans. 29 (6), 704-706.
Marangolo, M., Mc Gee, M., Tipton, K.F., Williams, D.C., & Zisterer, D.M. (2001) Oxidative stress induces apoptosis in C6-glioma cells: Involvement of mitogen-activated protein kinase and nuclear factor kappa B.Neurotoxicity Res. 3, 397-409.
Meegan, M.J., Hughes, R.B., Lloyd, D.G., Williams, D.C. & Zisterer, D.M. (2001) Ethyl side-chain modifications in novel flexible antiestrogens-design, synthesis and biological efficacy in assay against the MCF-7 breast tumour cell line. Anti-Cancer Drug Design 16, 57-69.
Zisterer, D.M., Campiani., Nacci, V. & Williams, D.C. Pyrrolobenzoxazepines induce apoptosis in HL-60, Jurkat and Hut-78 cells: A new class of apoptotic agents. J. Pharmacol. Exp. Ther. (2000) 293, 48-591.
Zisterer D.M., Campiani, G., Garafalo, A., Nacci, V. and Williams, D.C. Antiproliferative action of pyrrolobenzoxazepine derivatives in cultured cells. Biochem. Pharmacol. (1998) 55, 397-403.
Zisterer, D.M. and Williams, D.C. Calmidazolium and other imidazole compounds affect steroidogenesis in Y1 cells: lack of involvement of the peripheral-type benzodiazepine receptor. J. Steroid Biochem. Mol. Biol. (1997) 60, 189-195.
Zisterer, D.M. and Williams, D.C. Peripheral-type benzodiazepine receptors Gen. Pharmacol. (1997) 29, 305-314.
Marangolo, M., Zisterer, D.M., Williams, D.C., Tipton, K.F., Dixon, H.B.F. and Della Corte, L. Different specificities for taurine analogues and their target sites in brain. in Neurochemistry (Teelken & Korf, eds) (1997) pp 959-962.
Campiani G, Nacci V, Fiorini I, De Filippis MP, Garofalo A, Ciani SM, Greco G, Novellino E, Williams DC, Zisterer DM, Woods MJ, Mihai C, Manzoni C, Mennini T. Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific "peripheral-type" benzodiazepine receptor ligands. J Med Chem. (1996) 39, 3435-50.
Zisterer DM, Moynagh PN, Williams DC. Hexachlorocyclohexanes inhibit steroidogenesis in Y1 cells. Absence of correlation with binding to the peripheral-type benzodiazepine binding site. Biochem Pharmacol. (1996) 51,1303-8.
Woods MJ, Zisterer DM, Williams DC. Two cellular and subcellular locations for the peripheral-type benzodiazepine receptor in rat liver. Biochem Pharmacol. (1996) 51,1283-92.
Zisterer DM, Sunol C, Moynagh PN, Williams DC, Rodriguez-Farre E. PK 11195 reduces the brain availability of lindane in rats and the convulsions induced by this neurotoxic agent. Life Sci. (1995) 57,2359-64.
Zisterer DM, Gorman AM, Williams DC, Murphy MP. The effects of the peripheral-type benzodiazepine acceptor ligands, Ro5-4864 and PK 11195, on mitochondrial respiration. Methods Find Exp Clin Pharmacol. (1992) 14, 85-90.