Selected Publications
Herrera-Uribe J, Naylor P, Rajab E Coskuner G, Jassim MS Jassim, Al-Qahtani M & Stevenson NJ. Long term detection and quantification of SARS-CoV-2 RNA in wastewater in Bahrain. Journal of Hazardous Materials Advances, 2022, Volume 7.
Farid E, Herrera-Uribe J & Stevenson NJ. The Effect of Age, Gender and Comorbidities Upon SARS-CoV-2 Spike Antibody Induction After Two Doses of Sinopharm Vaccine and the Effect of a Pfizer/BioNtech Booster Vaccine. Frontiers in Immunology, 2022, 13:817597
Zhang Y, Gargan S, Roche FM, Frieman M and NJ Stevenson. Inhibition of the IFN-alpha JAK/STAT pathway by specific MERS-CoV and SARS-CoV-1 proteins in human epithelial cells. Viruses 2022, 14(4):667.
Wahaab A, Mustafa BE, Hameed M, Stevenson NJ, Anwar MN, Liu K, Wei J, Qiu Y and Ma Z. Potential role of flavivirus ns2b-ns3 proteases in viral pathogenesis and anti-flavivirus drug discovery employing animal cells and models: A review.Viruses 2022, 14, (1)44.
McKenna E, Wubben R, Isaza-Correa JM, Melo AM, Mhaonaigh AU, Conlon N and O’Donnell JS NÃ Cheallaigh C, Hurley T and Stevenson NJ and Little MA and Molloy EJ. Neutrophils in COVID-19: Not Innocent Bystanders. Frontiers in Immunology 2022, 13, 864387.
Gargan S & Stevenson NJ. Unravelling the immunomodulatory effects of viral ion channels, towards the treatment of disease. Viruses 2021, 13(11):2165.
Alqahtani M, Mallah SI, Stevenson NJ & Doherty S. Vaccine trials during a pandemic: potential approaches to ethical dilemmas. Trials 2021, 22(1), 628.
McKenna E, Ui Mhaonaigh A, Wubben R, Dwivedi A, Hurley T, Kelly L, Stevenson NJ, Little MA & Molloy EJ. Neutrophils: need for standardised nomenclature. Frontiers in Immunology 2021, 12, 602963.
Almadhi MA, Abdulrahman A, Sharaf SA, AlSaad D, Stevenson NJ, Atkin SL, AlQahtani MM. The high prevalence of asymptomatic SARS-CoV-2 infection reveals the silent spread of COVID-19. Int. J of Infectious Disease 2021, 105, pp. 656–661.
Zhang Y, Gargan S, Lu Y & Stevenson NJ. An overview of current knowledge of deadly CoVs and their interface with innate immunity. Viruses 2021, 13(4), 560.
Wubben R, Efstathiou C & Stevenson NJ. The interplay between the immune system and viruses. Vitamins and Hormones, 2021, 117, pp. 1–15 (Invited Book Chapter)
Efstathiou C, Abidi SH, Harker J and Stevenson NJ. Revisiting Respiratory Syncytial Virus’s Interaction with Host Immunity, Towards Novel Therapeutics. Cellular and Molecular Life Sciences, 2020 Jun 16, 1–14 2020
Convery O, Gargan S, Kickham M, Schroder M, O'Farrelly C, Stevenson NJ. The HCV protein, p7, suppresses inflammatory responses to TNF-α via STAT3 and ERK-mediated induction of SOCS3. FASEB J. 2019 Aug;33(8):8732-8744.
Gargan S, Ahmed S, Mahony R, Bannan C, Napoletano S, O'Farrelly C, Borrow P, Bergin C and Stevenson NJ. HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction. EBioMedicine. 2018 Apr;30:203-216.
Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C and Stevenson NJ. A novel anti-viral role for STAT3 in IFN-a signalling responses. Cell Mol Life Sci. 2017 May;74(9):1755-1764.
Bourke NM, Napoletano S, Bannan C, Ahmed S, Bergin C, McKnight Á and Stevenson NJ. Control of HIV infection by IFN-α: implications for latency and a cure. Cell Mol Life Sci. 2018 Mar;75(5):775-783.
Raftery N and Stevenson NJ. Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway. Cell Mol Life Sci. 2017 Jul;74(14):2525-2535.
Mahony R, Ahmed S, Diskin C and Stevenson NJ. SOCS3 revisited: a broad regulator of disease, ready for therapeutic use? Cell Mol Life Sci. 2016 Sep;73(17):3323-36.
Lui P-Y, Jin D-Y and Stevenson NJ. MicroRNA: master controllers of intracellular signalling pathways. Cell Mol Life Sci, 2015 Sep;72(18):3531-42.
Murray C, Griffin EW, O'Loughlin E, Lyons A, Sherwin E, Ahmed S, Stevenson NJ, Harkin A and Cunningham C.Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behavior responses to systemic poly I:C. Brain, Behavior, and Immunity, 2015 Aug;48:274-86.
Bourke NM, O'Neill M, Sarwar S, Norris S, Stewart S, Hegarty JE, Stevenson NJ and O'Farrelly C. In vitro Blood Cell Responsiveness to IFN-alpha Predicts Clinical Response Independently of IL28B in Hepatitis C Virus Genotype 1 Infected Patients. Journal of Translational Medicine, 2014,12:206.
Napoletano S, Bannan C, Bergin C and Stevenson NJ. HCV Immune Evasion in, Hepatitis C Virus: Molecular Pathways and Treatments. [http://esciencecentral.org/ebooks/hepatitis/hcv-immune-evasion.php] OMICS, 2014. (Book Chapter)
Collins AS, Ahmed S Napoletano S, Schroeder M, Johnston JA, Hegarty JE, O’Farrelly C and Stevenson NJ. Hepatitis C virus (HCV) induced suppressor of cytokine signalling (SOCS) 3 regulates proinflammatory tumour necrosis factor (TNF)-aresponses. Journal Leukoc Biol, 2014 Aug; 96(2):255-63
Collins AS, McCoy CE, Lloyd AT, O’Farrelly C and Stevenson NJ. miR-19a: an effective regulator of SOCS3 and enhancer of JAK-STAT signalling. PLoS ONE, 2013; Jul 22;8(7):e69090
Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, and O’Farrelly C. Hepatitis C Virus targets the Interferon-alpha JAK/STAT pathway by promoting proteosomal degradation in immune cells and hepatocytes. FEBS Lett. 2013; 587(10):1571-8.
Stevenson NJ, Murphy AG, Bourke NM, Keogh CA, Hegarty JE and O’Farrelly C. Ribavirin enhances IFN-alpha signalling and MxA expression: a novel immune modulation mechanism during treatment of HCV. PLoS ONE, 2011; 6(11):e27866
de la Vega M, Kelvin A, Dunican D, McFarlane C, Burrows J, Stevenson NJ, Dib K, Scott C, Long A and Johnston JA. The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. Nature Commun. 2011Mar 29;2:259
Ryan EJ, Stevenson NJ, Hegarty JE, O’Farrelly C. Chronic Hepatitis C infection blocks the ability of Dendritic Cells to secrete IFN-alpha and stimulate T cell proliferation. J Viral Hepat. 2011 Dec;18(12):840-51
Stevenson NJ, McFarlane C, Nahlik K, Ong ST, Nahlik K, Kelvin A, Addley MR, Long A, Greaves DR, O’Farrelly C and Johnston JA. Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine Eotaxin/CCL11. FEBS Lett. 2010 Nov 5; 584 (21): 4469-74
Ryan EJ, Dring M, Ryan CM, McNulty C, Stevenson NJ, Lawless MW, Crowe J, Nolan N, Hegarty JE, O'Farrelly C. A variant in the CD209 promoter is associated with the severity of liver disease in chronic Hepatitis C virus infection. Hum Immunol, 2010, Aug; 71 (8): 829-32
Stevenson NJ, Addley MR, Ryan EJ, Boyd CR, Carroll HP, Paunovic V, Bursill CA, Miller HC, Channon KM, McClurg AE, Armstrong MA, Coulter WA, Greaves DR, Johnston JA. CCL11 blocks IL-4 and GM-CSF signalling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signalling expression. J Leukoc Biol. 2009; 85 (2): 289-97
Elliott J, Lynch OT, Suessmuth Y, Qian P, Boyd CR ,Burrows JF, Buick R, Stevenson NJ, Touzelet O, Gadina M, Power UF, and Johnston JA. Respiratory Syncytial Virus NS1 Protein Degrades STAT2 by Using the Elongin-Cullin E3 Ligase. J Virol, 2007; 81 (7): 3428–3436
Stevenson NJ and Johnston JA. The Role of the Immune System in Cancer. Infection in the cancer patient. Oxford University Press. 2006; (2): 19-41. (Book Chapter)
Sommer U, Schmid C, Sobota RM, Lehmann U, Stevenson NJ, Johnston JA, Schaper F, Heinrich PC, Haan S. Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases. J Biol Chem. 2005; 280 (36): 31478-88
Stevenson NJ, Haan S, McClurg AE, Armstrong MA, Heinrich PC, Johnston JA. The chemoattractants, IL-8 and formyl-methionyl-leucyl-phenylalanine, regulate granulocyte colony-stimulating factor signalling by inducing suppressor of cytokine signaling-1 expression. J Immunol. 2004; 173 (5): 3243-9