Selected Publications
Noone J, Rooney MF, Karavyraki M, Yates A, O’Sullivan SE, Porter RK (2023). “Cancer-Cachexia-Induced Human Skeletal Muscle Myotube Degeneration is Prevented via Cannabinoid Receptor 2 Agonism in Vitro,” Pharmaceuticals 16, 1580. (https://www.mdpi.com/1424-8247/16/11/1580/pdf)
Keogh K, McKenna C, Waters SM, Porter RK, Fitzsimons C, McGee M, Kenny DA (2023) Effect of breed and diet on the M. longissimus thoracis et lumborum transcriptome of steers divergent for residual feed intake, Scientific Reports, 13(9034), DOI
Karavyraki M, Porter RK (2022) Evidence of a role for interleukin-6 in anoikis resistance in oral squamous cell carcinoma. Medical Oncology, 39, p60- DOI
Ge Z, Porter RK, Rooney MF (2022) Comparison of Phenotypes associated with Highly Invasive Triple-Negative Breast Cancer (TNBC) Cell Line and its Parental Counterpart. 12th International Cancer Conference, Trinity Biomedical Science Institute (TBSI) Ireland, Oct 2022, Meeting Abstract.
Karavyraki M, Gnaiger E, Porter RK (2022) Bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells, Bioenergetics Communications (BEC), DOI
Noone J, Karavyraki M, Rooney MF, Yates A, O'Sullivan SE, Porter RK (2022) A Role for Cannabinoids in Preventing Cachexia in an in vitro Human Muscle Cell Model., https://www.eventsforce.net/biochemsoc/frontend/reg/absViewDocumentFE.csp?documentID=3539&eventID=130, Drug Repurposing II, London, May 2022, edited by UK Biochemical Society, Conference Paper.
Rooney MF, Neto NGB, Monaghan MG, Hill EW, Porter RK (2022) Conditionally immortalised equine skeletal muscle cell lines for in vitro analysis, Biochemistry and Biophysics Reports, doi: 10.1016/j.bbrep.2022.101391
Keogh K, McKenna C, Porter RK, Waters SM, Kenny DA (2021) Effect of dietary restriction and subsequent realimentation on hepatic oxidative phosphorylation in cattle, Animal, 2021 Jan;15(1):100009. doi: 10.1016/j.animal.2020.2021, p100009-
O'Sullivan SE, Yates AS, Porter RK (2021) The peripheral cannabinoid receptor type 1 (CB1) as a molecular target for modulating body weight in man, Molecules, 26, (20), p6178-Review Article. DOI TARA - Full Text
McKenna C, Keogh K, Porter RK, Waters SM, Cormican P, Kenny DA (2021) An examination of skeletal muscle and hepatic tissue transcriptomes from beef cattle divergent for residual feed intake, Scientific reports, 11, (1), p8942- DOI
Dlasková A, Clarke KJ, Rooney MF, Porter RK (2021) The Use of Reactive Oxygen Species Production by Succinate Driven Reverse Electron Flow as an Index of Complex 1 Activity in Isolated Brown Adipose Tissue Mitochondria in, editor(s) Palmeira, Carlos M., Moreno, António J. (Eds.) , Methods Mol Biol. 2021;2310:247-258. doi: 10.1007/978-1-0716-1433-4_13.
O’Connor EB, Muñoz-Wolf N, Leon G, Lavelle EC, Mills KHG, Walsh PT, Porter RK. (2020) UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation, PLoS ONE, 15, (11), e02-https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239713
O'Brien EC, White CA, Wyse J, Leacy E, Porter RK, Little MA, Hickey FB (2020) Pro-inflammatory Stimulation of Monocytes by ANCA Is Linked to Changes in Cellular Metabolism
Front Med (Lausanne) 7: 553. doi: 10.3389/fmed.2020.00553
McKenna C, Porter RK, Fitzsimons C, Waters SM, McGee M, Kenny DA. (2020) Mitochondrial abundance and function in skeletal muscle and liver from Simmental beef cattle divergent for residual feed intake. Animal. 2020 Mar 16:1-8. doi: 10.1017/S1751731120000373.
Rooney MF, Curley CE, Sweeney J, Griffin ME, Porter RK, Hill EW, Katz LM (2020). Prolonged oral coenzyme Q10-β-cyclodextrin supplementation increases skeletal muscle complex I+III activity in young, untrained healthy Thoroughbreds, Journal of Applied Animal Nutrition 8(1) 11-20. https://doi.org/10.3920/JAAN2019.0001
O'Neill S, Porter RK, McNamee N, Martinez VG, O'Driscoll L. (2019) 2-Deoxy-D-Glucose inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype, Scientific Reports 9 (1) p3788 - 3798.
Rooney MF, Hill EW, Kelly VP, Porter RK. (2018) The "speed gene" effect of myostatin arises in Thoroughbred horses due to a promoter proximal SINE insertion. PLoS One.;13(10):e0205664. doi: 10.1371/journal.pone.0205664.
Ježek P, Jabůrek M, Porter RK.(2018) Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1).Biochim Biophys Acta Bioenerg. pii: S0005-2728(18)30170-1. doi: 10.1016/j.bbabio.2018.11.007. Review.
McKenna C, Porter RK, Keogh KA, Waters SM, McGee M, Kenny DA (2018) Residual feed intake phenotype and gender affect the expression of key genes of the lipogenesis pathway in subcutaneous adipose tissue of beef cattle, J Animal Sci Biotech 9, p68 - 78
Clarke KJ, Porter RK (2018) The Importance of Calcium Ions for Determining Mitochondrial Glycerol-3-Phosphate Dehydrogenase Activity When Measuring Uncoupling Protein 1 (UCP1) Function in Mitochondria Isolated from Brown Adipose Tissue. Methods Mol Biol.;1782:325-336.
Karavyraki M, Porter RK (2018) Mitochondrial function linked to metabolic differences in dysplastic and cancerous oral cells EBEC Short Reports (2018) Budapest
Curley CE, Rooney MF, Griffin ME, Katz LM, Porter RK, Hill EW (2018) Supplementation with MicroActive coenzyme Q10 increases plasma and skeletal muscle coenzyme Q10 levels in healthy Thoroughbred horses. EBEC Short Reports (2018) Budapest
Rooney MF, Hill EW, Katz LM, Porter RK (2108) Genotype variation at the MSTN locus is associated with skeletal muscle Coenzyme Q level in untrained Thoroughbred horses. EBEC Short Reports (2018) Budapest
O’Connor E, Walsh PT, Porter RK (2018) The Role of Mitochondrial Uncoupling Protein 3 (UCP3) in CD4+ T Cells, EBEC Short Reports (2018) Budapest
Rooney MF, Porter RK, Katz LM, Hill EW.(2017) Skeletal muscle mitochondrial bioenergetics and associations with myostatin genotypes in the Thoroughbred horse. PLoS One. 2017 Nov 30;12(11):e0186247
Geoghegan F, Buckland RJ, Rogers ET, Khalifa K, O'Connor EB, Rooney MF, Behnam-Motlagh P, Nilsson TK, Grankvist K, Porter RK. Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells. Oncotarget. 2017 Oct 16;8(55):94711-94725. doi: 10.18632/oncotarget.21885.
Martinez VG, Crown J, Porter RK, O'Driscoll L. (2017) Neuromedin U alters bioenergetics and expands the cancer stem cell phenotype in HER2-positive breast cancer. Int J Cancer. 140(12):2771-2784.
Emma B. O’Connor, Richard K. Porter and Patrick T. Walsh (2017) A Role for Mitochondrial Uncoupling Protein 3 (UCP3) in T-cell function, (abstract submitted for Keystone Meeting, Dublin, Ireland)
Geoghegan F, Chadderton N, Farrar GJ, Zisterer DM, Porter RK. (2017) Direct effects of phenformin on metabolism/bioenergetics and viability of SH-SY5Y neuroblastoma cells. Oncol Lett. 14(5):6298-6306.
Mary F Rooney, Emmeline W Hill, Lisa M Katz and Richard K Porter (2016) MSTN genotype variation affects skeletal muscle mitochondrial abundance and fibre composition in untrained Thoroughbred horses, Biochimica et Biophysica Acta (BBA) – Bioenergetics, Volume 1857, Supplement, p44
Emma B. O’Connor, Richard K. Porter and Patrick T. Walsh (2016) A Role for Mitochondrial Uncoupling Protein 3 (UCP3) in T-cell function, Biochimica et Biophysica Acta (BBA) – Bioenergetics, Volume 1857, Supplement, P117
Martin DS, Leonard S, Devine R, Redondo C, Kinsella GK, Breen CJ, McEneaney V, Rooney MF, Munsey TS, Porter RK, Sivaprasadarao A, Stephens JC, Findlay J. (2016) Novel mitochondrial complex I inhibitors restore glucose-handling abilities of high-fat fed mice. J Mol Endocrinol. 2016 Jan 12. pii: JME-15-0225. [Epub ahead of print]
Lynam-Lennon N, Connaughton R, Carr E, Mongan AM, O'Farrell NJ, Porter RK, Brennan L, Pidgeon GP, Lysaght J, Reynolds JV, O'Sullivan J. (2014) Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma. BMC Cancer. 14:907. doi: 10.1186/1471-2407-14-907.
Clarke, K.J., Carroll, A.M., O’Brien, G. and Porter, R.K. (2014) Detection of UCP1 Protein and measurements of dependent GDP-sensitive proton leak in non-phosphorylating thymus mitochondria, “Mitochondrial regulation” Methods in Molecular Biology, 1241, 123-136
Eamon P. Breen, Wayne Pilgrim, Kieran J. Clarke, Cristy Yssel, Mark Farrell, Jian Zhou, Paul V. Murphy & Richard K. Porter, (2013) Lack of activation of UCP1 in isolated brown adipose tissue mitochondria by glucose-O-ω-modified saturated fatty acids of various chain lengths. J Chem. Biol. 6(3):121-33.
Clarke KJ, Porter RK. (2013) Uncoupling protein 1 dependent reactive oxygen species production by thymus mitochondria. Int. J. Biochem. Cell Biol. 45(1):81-9.
Clarke, K.J., Adams, A.E., Manzke, L., Pearson, T.W., Borchers, C.H., Porter, R.K. (2012) A Role for Ubiquitinylation and the Cytosolic Proteasome in Turnover of Mitochondrial Uncoupling Protein 1 (UCP1) Biochim Biophys Acta (Bioenergetics) 1817(10):1759-67
Porter RK. (2012) Studies on the function and regulation of mitochondrial uncoupling proteins. Adv Exp Med Biol. 748:171-84.
Kelly, O.M. and Porter, R.K. (2011) Absence of mitochondrial uncoupling protein 3: effect on thymus and spleen in the fed and fasted mice. Biochim Biophys Acta 1807, 1064-74.
Kelly, O.M., McNamara, Y.M., Manzke, L.H., Meegan, M.J. and Porter, R.K. (2011) The Preservation of in vivo Phosphorylated and Activated Uncoupling Protein 3 (UCP3) in Isolated Skeletal Muscle Mitochondria following Administration of 3,4-Methylenedioxymethamphetamine (MDMA aka Ecstasy) to Rats/Mice. Mitochondrion 12(1) 110-9. Epub 2011 Mar 29.
Adams, A. E., Kelly, O.M. & Porter, R. K. (2010) Absence of Mitochondrial Uncoupling Protein 1 Affects Apoptosis in Thymocytes, Thymocyte/T-Cell profile and Peripheral T-Cell Number Biochimica Biophysica Acta (Bioenergetics), 1797, 807-816
Dlaskovà, A., Clarke, K. and Porter, R.K. (2010) The role of UCP 1 in the production of reactive oxygen species by mitochondria isolated from brown adipose tissue. Biochimica Biophysica Acta (Bioenergetics), 1797, 1470-1476
O'Donoghue, N., Donagh, R., Sweeney, T. and Porter, R.K. (2009) Control of Choline Oxidation in Kidney Mitochondria, Biochimica Biophysica Acta (Bioenergetics), 1787, 1135-1139
Murphy, J. E.J. and Porter, R. K. (2009) The Control of Oxidative Phosphorylation in the Adrenal Gland Cell Line (Y1) in Advances in Experimental Medicine and Biology 645, 35-41
Porter R. K. (2008) Uncoupling protein 1: A short-circuit in the Chemiosmotic process, The Journal of Bioenergetics and Biomembranes, 40, 457-461
Carroll, A. M., Porter, R. K. & Morrice, N. A. (2008) Identification of serine phosphorylation in mitochondrial uncoupling protein 1, Biochimica Biophysica Acta (Bioenergetics), 1777, (7-8), 2008, p1060 – 1065
Adams, A. E., Carroll, A. M., Fallon, P. G. & Porter, R. K. (2008) Mitochondrial uncoupling protein 1 expression in thymocytes, Biochimica Biophysica Acta (Bioenergetics), 1777, (7-8), 2008, p772 – 775
Adams, A.E., Hanrahan, O., Nolan, D.N., Voorheis, H.P. Fallon, P. and Porter, R.K., Images of Mitochondrial UCP 1 in Mouse Thymocytes using Confocal Microscopy, Biochimica Biophysica Acta (Bioenergetics), 1777, 2007, p115 - 117
Beck, V., Jabůrek, M., Demina, T., Rupprecht, A., Porter, R.K., Ježek, P. and Pohl, E.E. (2007) high efficiency of polyunsaturated fatty acids in the activation of human uncoupling protein 1 and 2 reconstituted in planar lipid bilayers. FASEB J. 4, 1137-1144.
Brennan, C.M., Breen, E.P. and Porter, R.K. (2006) Cold acclimation and oxygen consumption in the thymus. Biochim. Biophys. Acta 1757, 1463-1468.