Selected Publications
Liver immunology and its role in inflammation and homeostasis. Robinson MW, Harmon C, O’Farrelly C. Cellular & Molecular Immunology (2016) 13, 267–276; doi:10.1038/cmi.2016.3 http://www.ncbi.nlm.nih.gov/pubmed/27063467
Natural Killer Cells and Liver Transplantation: Orchestrators of Rejection or Tolerance? Harmon C, Sanchez-Fueyo A, O'Farrelly C, Houlihan DD. Am J Transplant. 2016 Mar;16(3):751-7. doi: 10.1111/ajt.13565. Epub 2015 Dec 21. Review. http://www.ncbi.nlm.nih.gov/pubmed/26690302
The microenvironment of visceral adipose tissue and liver alter natural killer cell viability and function. Conroy MJ, Fitzgerald V, Doyle SL, Channon S, Useckaite Z, Gilmartin N, O'Farrelly C, Ravi N, Reynolds JV, Lysaght J. J Leukoc Biol. 2016 Jun 30. pii: jlb.5AB1115-493RR. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/27365528
CCR1 antagonism attenuates T cell trafficking to omentum and liver in obesity-associated cancer. Conroy MJ, Galvin KC, Kavanagh ME, Mongan AM, Doyle SL, Gilmartin N, O'Farrelly C, Reynolds JV, Lysaght J. Immunol Cell Biol. 2016 Jul;94(6):531-7. doi: 10.1038/icb.2016.26. Epub 2016 Apr 5. PMID: 27046081 http://www.ncbi.nlm.nih.gov/pubmed/27046081
CD141+myeloid dendritic cells are enriched in healthy human liver. (2013) Kelly A, Fahey R, Fletcher JM, Keogh C, Carroll AG, Siddachari R, Geoghegan J, Hegarty JE, Ryan J, O'Farrelly C. J Hepatol. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/23968887
Hepatitis C virus targets the interferon-α JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes. (2013) Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C. FEBS Lett. 21;587(10):1571-8. http://www.ncbi.nlm.nih.gov/pubmed/23587486
Endometrial aspiration biopsy: a non-invasive method of obtaining functional lymphoid progenitor cells and mature natural killer cells (2012) McMenamin M, Lysakova-Devine T, Wingfield M, O'Herlihy C, O'Farrelly C. Reprod Biomed Online. 25(3):322-8. http://www.ncbi.nlm.nih.gov/pubmed/22796232
Global endometrial transcriptomic profiling: transient immune activation precedes tissue proliferation and repair in healthy beef cows. (2012) Foley C, Chapwanya A, Creevey CJ, Narciandi F, Morris D, Kenny EM, Cormican P, Callanan JJ, O'Farrelly C, Meade KG. BMC Genomics. 18;13:489. http://www.ncbi.nlm.nih.gov/pubmed/22985206
Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide. (2011) Hogan AE, O'Reilly V, Dunne MR, Dere RT, Zeng SG, O'Brien C, Amu S, Fallon PG, Exley MA, O'Farrelly C, Zhu X, Doherty DG. Clin Immunol. 140(2):196-207. http://www.ncbi.nlm.nih.gov/pubmed/21493160
Chronic hepatitis C infection blocks the ability of dendritic cells to secrete IFN-α and stimulate T-cell proliferation. (2011) Ryan EJ, Stevenson NJ, Hegarty JE, O'Farrelly C. J Viral Hepat. 2011 Dec;18(12):840-51. http://www.ncbi.nlm.nih.gov/pubmed/22093032
Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection. (2011) Dring MM, Morrison MH, McSharry BP, Guinan KJ, Hagan R; Irish HCV Research Consortium, O'Farrelly C, Gardiner CM. Proc Natl Acad Sci U S A. 108(14):5736-41. http://www.ncbi.nlm.nih.gov/pubmed/21402922
Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion. (2011) Petrovic D, Stamataki Z, Dempsey E, Golden-Mason L, Freeley M, Doherty D, Prichard D, Keogh C, Conroy J, Mitchell S, Volkov Y, McKeating JA, O'Farrelly C, Kelleher D, Long A. Hepatology. 53(6):1846-53. http://www.ncbi.nlm.nih.gov/pubmed/21452285
The differential evolutionary dynamics of avian cytokine and TLR gene classes. (2010) Downing T, Lloyd AT, O'Farrelly C, Bradley DG. J Immunol. 184(12):6993-7000. http://www.ncbi.nlm.nih.gov/pubmed/20483729
Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility. (2009) McGrath E, Ryan EJ, Lynch L, Golden-Mason L, Mooney E, Eogan M, O'Herlihy C, O'Farrelly C. Am J Reprod Immunol. 61(4):265-76. http://www.ncbi.nlm.nih.gov/pubmed/19260857
Microanatomy of the liver immune system. (2009) Nemeth E, Baird AW, O'Farrelly C. Semin Immunopathol. 31(3):333-43. http://www.ncbi.nlm.nih.gov/pubmed/19639317
Evidence of the adaptive evolution of immune genes in chicken. (2009) Downing T, Cormican P, O'Farrelly C, Bradley DG, Lloyd AT. BMC Res Notes. 2:254. http://www.ncbi.nlm.nih.gov/pubmed/20003477
Divergent antimicrobial peptide (AMP) and acute phase protein (APP) responses to Trypanosoma congolense infection in trypanotolerant and trypanosusceptible cattle. (2009) Meade KG, O'Gorman GM, Hill EW, Narciandi F, Agaba M, Kemp SJ, O'Farrelly C, MacHugh DE. Mol Immunol. 47(2-3):196-204. http://www.ncbi.nlm.nih.gov/pubmed/19889461
Invariant NKT cells and CD1d-positive cells amass in human omentum and are depleted in patients with cancer and obesity. Lynch, L, O'Shea, D, Winter, D, Geoghegan, J, Doherty, D and O'Farrelly, C (2009). Eur. J. Immunol. 39(7):1893-901. http://www.ncbi.nlm.nih.gov/pubmed/19585513
Evolution, expression and effectiveness in a cluster of novel bovine beta-defensins. (2008) Cormican P, Meade KG, Cahalane S, Narciandi F, Chapwanya A, Lloyd AT, O'Farrelly C. Immunogenetics. 60(3-4):147-56. http://www.ncbi.nlm.nih.gov/pubmed/18369613
Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-beta. (2008) Rowan AG, Fletcher JM, Ryan EJ, Moran B, Hegarty JE, O'Farrelly C, Mills KH. J Immunol. 181(7):4485-94. http://www.ncbi.nlm.nih.gov/pubmed/18802051
Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure. (2008) Golden-Mason L, Madrigal-Estebas L, McGrath E, Conroy MJ, Ryan EJ, Hegarty JE, O'Farrelly C, Doherty DG. Gut. 57(8):1121-8. http://www.ncbi.nlm.nih.gov/pubmed/18372499
Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection. (2007) Golden-Mason L, Castelblanco N, O'Farrelly, Rosen HR. J Virol. 81(17):9292-8. http://www.ncbi.nlm.nih.gov/pubmed/17553896
Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility? (2007) Lynch L, Golden-Mason L, Eogan M, O'Herlihy C, O'Farrelly C. Hum Reprod. 22(4):919-26. http://www.ncbi.nlm.nih.gov/pubmed/17208945