Selected Publications
Sutton, C., Brereton, C., Keogh, B., Mills, K. H. and Lavelle, E. C., A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 2006. 203: 1685-1691.
Braat, H., McGuirk, P., Ten Kate, F. J., Huibregtse, I., Dunne, P. J., Hommes, D. W., Van Deventer, S. J. and Mills, K. H., Prevention of experimental colitis by parenteral administration of a pathogen-derived immunomodulatory molecule. Gut 2007. 56: 351-357.
Conroy, H., Marshall, N. A. and Mills, K. H., TLR ligand suppression or enhancement of Treg cells? A double-edged sword in immunity to tumours. Oncogene 2008. 27: 168-180.
Jarnicki, A. G., Conroy, H., Brereton, C., Donnelly, G., Toomey, D., Walsh, K., Sweeney, C., Leavy, O., Fletcher, J., Lavelle, E. C., Dunne, P. and Mills, K. H., Attenuating regulatory T cell induction by TLR agonists through inhibition of p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics. J Immunol 2008. 180: 3797-3806.
Mills, K. H., Induction, function and regulation of IL-17-producing T cells. Eur J Immunol 2008. 38: 2636-2649.
Mills, K. H., TLR9 turns the tide on Treg cells. Immunity 2008. 29: 518-520.
Rowan, A. G., Fletcher, J. M., Ryan, E. J., Moran, B., Hegarty, J. E., O'Farrelly, C. and Mills, K. H., Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-beta. J Immunol 2008. 181: 4485-4494.
Brereton, C. F., Sutton, C. E., Lalor, S. J., Lavelle, E. C. and Mills, K. H., Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease. J Immunol 2009. 183: 1715-1723.
Dunne, P. J., Moran, B., Cummins, R. C. and Mills, K. H., CD11c+CD8alpha+ dendritic cells promote protective immunity to respiratory infection with Bordetella pertussis. J Immunol 2009. 183: 400-410.
Fletcher, J. M., Lonergan, R., Costelloe, L., Kinsella, K., Moran, B., O'Farrelly, C., Tubridy, N. and Mills, K. H., CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis. J Immunol 2009. 183: 7602-7610.
Mills, K. H. and Dunne, A., Immune modulation: IL-1, master mediator or initiator of inflammation. Nat Med 2009. 15: 1363-1364.
Sutton, C. E., Lalor, S. J., Sweeney, C. M., Brereton, C. F., Lavelle, E. C. and Mills, K. H., Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 2009. 31: 331-341.
Walsh, K. P., Brady, M. T., Finlay, C. M., Boon, L. and Mills, K. H., Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses. J Immunol 2009. 183: 1577-1586.
Dunne, A., Ross, P. J., Pospisilova, E., Masin, J., Meaney, A., Sutton, C. E., Iwakura, Y., Tschopp, J., Sebo, P. and Mills, K. H., Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis. J Immunol 2010. 185: 1711-1719.
Fletcher, J. M., Lalor, S. J., Sweeney, C. M., Tubridy, N. and Mills, K. H., T cells in multiple sclerosis and experimental autoimmune encephalomyelitis. Clin Exp Immunol 2010. 162: 1-11.
Masters, S. L., Dunne, A., Subramanian, S. L., Hull, R. L., Tannahill, G. M., Sharp, F. A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., Mullooly, N., Mielke, L. A., Harris, J., Coll, R. C., Mills, K. H., Mok, K. H., Newsholme, P., Nunez, G., Yodoi, J., Kahn, S. E., Lavelle, E. C. and O'Neill, L. A., Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes. Nat Immunol 2010. 11: 897-904.
Masters, S. L., Mielke, L. A., Cornish, A. L., Sutton, C. E., O'Donnell, J., Cengia, L. H., Roberts, A. W., Wicks, I. P., Mills, K. H. and Croker, B. A., Regulation of interleukin-1beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production. EMBO Rep 2010. 11: 640-646.
McQuillan, K., Lynch, M. A. and Mills, K. H., Activation of mixed glia by Abeta-specific Th1 and Th17 cells and its regulation by Th2 cells. Brain Behav Immun 2010. 24: 598-607.
Murphy, A. C., Lalor, S. J., Lynch, M. A. and Mills, K. H., Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis. Brain Behav Immun 2010. 24: 641-651.
O'Brien, M., Lonergan, R., Costelloe, L., O'Rourke, K., Fletcher, J. M., Kinsella, K., Sweeney, C., Antonelli, G., Mills, K. H., O'Farrelly, C., Hutchinson, M. and Tubridy, N., OAS1: a multiple sclerosis susceptibility gene that influences disease severity. Neurology 2010. 75: 411-418.
Brereton, C. F., Sutton, C. E., Ross, P. J., Iwakura, Y., Pizza, M., Rappuoli, R., Lavelle, E. C. and Mills, K. H., Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection by driving innate IL-1 and IL-23 production. J Immunol 2011. 186: 5896-5906.
Byrne, W. L., Mills, K. H., Lederer, J. A. and O'Sullivan, G. C., Targeting regulatory T cells in cancer. Cancer Res 2011. 71: 6915-6920.
Dunne, A., Marshall, N. A. and Mills, K. H., TLR based therapeutics. Curr Opin Pharmacol 2011. 11: 404-411.
Lalor, S. J., Dungan, L. S., Sutton, C. E., Basdeo, S. A., Fletcher, J. M. and Mills, K. H., Caspase-1-processed cytokines IL-1beta and IL-18 promote IL-17 production by gammadelta and CD4 T cells that mediate autoimmunity. J Immunol 2011. 186: 5738-5748.
McLoughlin, R. M. and Mills, K. H., Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma. J Allergy Clin Immunol 2011. 127: 1097-1107; quiz 1108-1099.
Mills, K. H., TLR-dependent T cell activation in autoimmunity. Nat Rev Immunol 2011. 11: 807-822.
Allen, A. C., Kelly, S., Basdeo, S. A., Kinsella, K., Mulready, K. J., Mills, K. H., Tubridy, N., Walsh, C., Brady, J. J., Hutchinson, M. and Fletcher, J. M., A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers. Mult Scler 2012. 18: 1797-1800.
Conroy, H., Galvin, K. C., Higgins, S. C. and Mills, K. H., Gene silencing of TGF-beta1 enhances antitumor immunity induced with a dendritic cell vaccine by reducing tumor-associated regulatory T cells. Cancer Immunol Immunother 2012. 61: 425-431.
Higgs, R., Higgins, S. C., Ross, P. J. and Mills, K. H., Immunity to the respiratory pathogen Bordetella pertussis. Mucosal Immunol 2012. 5: 485-500.
Jones, S. A., Sutton, C. E., Cua, D. and Mills, K. H., Therapeutic potential of targeting IL-17. Nat Immunol 2012. 13: 1022-1025.
Lynch, M. A. and Mills, K. H., Immunology meets neuroscience--opportunities for immune intervention in neurodegenerative diseases. Brain Behav Immun 2012. 26: 1-10.
Marshall, N. A., Galvin, K. C., Corcoran, A. M., Boon, L., Higgs, R. and Mills, K. H., Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-gamma+IL-17+ polyfunctional T cells that mediate rejection of murine tumors. Cancer Res 2012. 72: 581-591.
Sutton, C. E., Mielke, L. A. and Mills, K. H., IL-17-producing gammadelta T cells and innate lymphoid cells. Eur J Immunol 2012. 42: 2221-2231.
Browne, T. C., McQuillan, K., McManus, R. M., O'Reilly, J. A., Mills, K. H. and Lynch, M. A., IFN-gamma Production by amyloid beta-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease. J Immunol 2013. 190: 2241-2251.
Coleman, M. M., Ruane, D., Moran, B., Dunne, P. J., Keane, J. and Mills, K. H., Alveolar macrophages contribute to respiratory tolerance by inducing FoxP3 expression in naive T cells. Am J Respir Cell Mol Biol 2013. 48: 773-780.
Galvin, K. C., Dyck, L., Marshall, N. A., Stefanska, A. M., Walsh, K. P., Moran, B., Higgins, S. C., Dungan, L. S. and Mills, K. H., Blocking retinoic acid receptor-alpha enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells. Cancer Immunol Immunother 2013. 62: 1273-1282.
Mielke, L. A., Jones, S. A., Raverdeau, M., Higgs, R., Stefanska, A., Groom, J. R., Misiak, A., Dungan, L. S., Sutton, C. E., Streubel, G., Bracken, A. P. and Mills, K. H., Retinoic acid expression associates with enhanced IL-22 production by gammadelta T cells and innate lymphoid cells and attenuation of intestinal inflammation. J Exp Med 2013. 210: 1117-1124.
Mills, K. H., Dungan, L. S., Jones, S. A. and Harris, J., The role of inflammasome-derived IL-1 in driving IL-17 responses. J Leukoc Biol 2013. 93: 489-497.
Ross, P. J., Sutton, C. E., Higgins, S., Allen, A. C., Walsh, K., Misiak, A., Lavelle, E. C., McLoughlin, R. M. and Mills, K. H., Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine. PLoS Pathog 2013. 9: e1003264.
Walsh, K. P. and Mills, K. H., Dendritic cells and other innate determinants of T helper cell polarisation. Trends Immunol 2013. 34: 521-530.
Allen, A. C. and Mills, K. H., Improved pertussis vaccines based on adjuvants that induce cell-mediated immunity. Expert Rev Vaccines 2014. 13: 1253-1264.
Dungan, L. S., McGuinness, N. C., Boon, L., Lynch, M. A. and Mills, K. H., Innate IFN-gamma promotes development of experimental autoimmune encephalomyelitis: a role for NK cells and M1 macrophages. Eur J Immunol 2014. 44: 2903-2917.
Finlay, C. M., Walsh, K. P. and Mills, K. H., Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases. Immunol Rev 2014. 259: 206-230.
Mills, K. H., Prior exposure to bacteria attenuates viral disease of the respiratory tract: a role for IL-17 and innate immune memory? Am J Respir Crit Care Med 2014. 189: 126-128.
Mills, K. H., Ross, P. J., Allen, A. C. and Wilk, M. M., Do we need a new vaccine to control the re-emergence of pertussis? Trends Microbiol 2014. 22: 49-52.
Murphy, A. G., O'Keeffe, K. M., Lalor, S. J., Maher, B. M., Mills, K. H. and McLoughlin, R. M., Staphylococcus aureus infection of mice expands a population of memory gammadelta T cells that are protective against subsequent infection. J Immunol 2014. 192: 3697-3708.
Raverdeau, M. and Mills, K. H., Modulation of T cell and innate immune responses by retinoic Acid. J Immunol 2014. 192: 2953-2958.
Basdeo, S. A., Moran, B., Cluxton, D., Canavan, M., McCormick, J., Connolly, M., Orr, C., Mills, K. H., Veale, D. J., Fearon, U. and Fletcher, J. M., Polyfunctional, Pathogenic CD161+ Th17 Lineage Cells Are Resistant to Regulatory T Cell-Mediated Suppression in the Context of Autoimmunity. J Immunol 2015. 195: 528-540.
Bernard, N. J., Finlay, C. M., Tannahill, G. M., Cassidy, J. P., O'Neill, L. A. and Mills, K. H., A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis. Mucosal Immunol 2015. 8: 982-992.
Brummelman, J., Wilk, M. M., Han, W. G., van Els, C. A. and Mills, K. H., Roads to the development of improved pertussis vaccines paved by immunology. Pathog Dis 2015. 73: ftv067.
Coll, R. C., Robertson, A. A., Chae, J. J., Higgins, S. C., Muñoz-Planillo, R., Inserra, M. C., Vetter, I., Dungan, L. S., Monks, B. G., Stutz, A., Croker, D. E., Butler, M. S., Haneklaus, M., Sutton, C. E., Núñez, G., Latz, E., Kastner, D. L., Mills, K. H., Masters, S. L., Schroder, K., Cooper, M. A. and O'Neill, L. A., A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med 2015. 21: 248-255.
Dunne, A., Mielke, L. A., Allen, A. C., Sutton, C. E., Higgs, R., Cunningham, C. C., Higgins, S. C. and Mills, K. H., A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine. Mucosal Immunol 2015. 8: 607-617.
Edwards, S. C., Higgins, S. C. and Mills, K. H. G., Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction. Brain Behav Immun 2015. 50: 41-46.
Edwards, S. C., McGinley, A. M., McGuinness, N. C. and Mills, K. H., gammadelta T Cells and NK Cells - Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity. Front Immunol 2015. 6: 455.
Netea, M. G., Latz, E., Mills, K. H. and O'Neill, L. A., Innate immune memory: a paradigm shift in understanding host defense. Nat Immunol 2015. 16: 675-679.
Oficjalska, K., Raverdeau, M., Aviello, G., Wade, S. C., Hickey, A., Sheehan, K. M., Corr, S. C., Kay, E. W., O'Neill, L. A., Mills, K. H. and Creagh, E. M., Protective role for caspase-11 during acute experimental murine colitis. J Immunol 2015. 194: 1252-1260.
Murphy, A. G., O'Keeffe, K. M., Lalor, S. J., Maher, B. M., Mills, K. H. and McLoughlin, R. M., Correction: Staphylococcus aureus Infection of mice expands a population of memory γδ T cells that are protective against subsequent infection. J Immunol 2015. 194: 4588
Dyck, L., Wilk, M. M., Raverdeau, M., Misiak, A., Boon, L. and Mills, K. H., Anti-PD-1 inhibits Foxp3(+) Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model. Cancer Immunol Immunother 2016. 65: 1491-1498.
Exley, M. A., Tsokos, G. C., Mills, K. H., Elewaut, D. and Mulhearn, B., What rheumatologists need to know about innate lymphocytes. Nat Rev Rheumatol 2016. 12: 658-668.
Finlay, C. M., Stefanska, A. M., Walsh, K. P., Kelly, P. J., Boon, L., Lavelle, E. C., Walsh, P. T. and Mills, K. H., Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia. J Immunol 2016. 196: 703-714.
Gardiner, C. M. and Mills, K. H., The cells that mediate innate immune memory and their functional significance in inflammatory and infectious diseases. Semin Immunol 2016. 28: 343-350.
Lee, J. P., Foote, A., Fan, H., Peral de Castro, C., Lang, T., Jones, S. A., Gavrilescu, N., Mills, K. H., Leech, M., Morand, E. F. and Harris, J., Loss of autophagy enhances MIF/macrophage migration inhibitory factor release by macrophages. Autophagy 2016. 12: 907-916.
Mulcahy, M. E., Leech, J. M., Renauld, J. C., Mills, K. H. and McLoughlin, R. M., Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa. Mucosal Immunol 2016. 9: 1429-1441.
Netea, M. G., Joosten, L. A., Latz, E., Mills, K. H., Natoli, G., Stunnenberg, H. G., O'Neill, L. A. and Xavier, R. J., Trained immunity: A program of innate immune memory in health and disease. Science 2016. 352: aaf1098.
Raverdeau, M., Breen, C. J., Misiak, A. and Mills, K. H., Retinoic acid suppresses IL-17 production and pathogenic activity of gammadelta T cells in CNS autoimmunity. Immunol Cell Biol 2016. 94: 763-773.
Dyck, L. and Mills, K. H. G., Immune checkpoints and their inhibition in cancer and infectious diseases. Eur J Immunol 2017. 47: 765-779.
Finlay, C. M., Stefanska, A. M., Coleman, M. M., Jahns, H., Cassidy, J. P., McLoughlin, R. M. and Mills, K. H. G., Secreted products of Fasciola hepatica inhibit the induction of T cell responses that mediate allergy. Parasite Immunol 2017. 39.
McManus, R. M., Finucane, O. M., Wilk, M. M., Mills, K. H. G. and Lynch, M. A., FTY720 Attenuates Infection-Induced Enhancement of Abeta Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation. J Neuroimmune Pharmacol 2017. 12: 670-681.
Misiak, A., Leuzzi, R., Allen, A. C., Galletti, B., Baudner, B. C., D'Oro, U., O'Hagan, D. T., Pizza, M., Seubert, A. and Mills, K. H. G., Addition of a TLR7 agonist to an acellular pertussis vaccine enhances Th1 and Th17 responses and protective immunity in a mouse model. Vaccine 2017. 35: 5256-5263.
Misiak, A., Wilk, M. M., Raverdeau, M. and Mills, K. H., IL-17-Producing Innate and Pathogen-Specific Tissue Resident Memory gammadelta T Cells Expand in the Lungs of Bordetella pertussis-Infected Mice. J Immunol 2017. 198: 363-374.
Nascimento, I. P., Rodriguez, D., Santos, C. C., Amaral, E. P., Rofatto, H. K., Junqueira-Netea, M. G., Balkwill, F., Chonchol, M., Cominelli, F., Donath, M. Y., Giamarellos-Bourboulis, E. J., Golenbock, D., Gresnigt, M. S., Heneka, M. T., Hoffman, H. M., Hotchkiss, R., Joosten, L. A. B., Kastner, D. L., Korte, M., Latz, E., Libby, P., Mandrup-Poulsen, T., Mantovani, A., Mills, K. H. G., Nowak, K. L., O'Neill, L. A., Pickkers, P., van der Poll, T., Ridker, P. M., Schalkwijk, J., Schwartz, D. A., Siegmund, B., Steer, C. J., Tilg, H., van der Meer, J. W. M., van de Veerdonk, F. L. and Dinarello, C. A., A guiding map for inflammation. Nat Immunol 2017. 18: 826-831.
Palsson-McDermott, E. M., Dyck, L., Zaslona, Z., Menon, D., McGettrick, A. F., Mills, K. H. G. and O'Neill, L. A., Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors. Front Immunol 2017. 8: 1300.
Sutton, C. E., Finlay, C. M., Raverdeau, M., Early, J. O., DeCourcey, J., Zaslona, Z., O'Neill, L. A. J., Mills, K. H. G. and Curtis, A. M., Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease. Nat Commun 2017. 8: 1923.
Varghese, S., Cotter, M., Chevot, F., Fergus, C., Cunningham, C., Mills, K. H., Connon, S. J., Southern, J. M. and Kelly, V. P., In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis. Nucleic Acids Res 2017. 45: 2029-2039.
Wilk, M. M., Misiak, A., McManus, R. M., Allen, A. C., Lynch, M. A. and Mills, K. H. G., Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice with Bordetella pertussis. J Immunol 2017. 199: 233-243.
Borkner, L., Misiak, A., Wilk, M. M. and Mills, K. H. G., Azithromycin Clears Bordetella pertussis Infection in Mice but Also Modulates Innate and Adaptive Immune Responses and T Cell Memory. Front Immunol 2018. 9: 1764.
McGinley, A. M., Edwards, S. C., Raverdeau, M. and Mills, K. H. G., Th17cells, gammadelta T cells and their interplay in EAE and multiple sclerosis. J Autoimmun 2018.
Allen, A. C., Wilk, M. M., Misiak, A., Borkner, L., Murphy, D. and Mills, K. H. G., Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting TRM cells. Mucosal Immunol 2018. Aug 20. doi: 10.1038/s41385-018-0080-x.
Solans, L., Debrie, A. S., Borkner, L., Aguilo, N., Thiriard, A., Coutte, L., Uranga, S., Trottein, F., Martin, C., Mills, K. H. G. and Locht, C., IL-17-dependent SIgA-mediated protection against nasal Bordetella pertussis infection by live attenuated BPZE1 vaccine. Mucosal Immunol 2018.
Wilk, M. M. and Mills, K. H. G., CD4 TRM Cells Following Infection and Immunization: Implications for More Effective Vaccine Design. Front Immunol 2018. 9: 1860.
Diavatopoulos DA, M. K., Kester KE, Kampmann B, Silerova M, Heininger U, van Dongen JJM, van der Most RG, Huijnen MA, Siena E, Mielcarek N, Ochs MM, Denoël P, Berbers G, Buisman AM, de Jonge MI, Fenwick C, Gorringe A, He Q, Kelly D, Le Grand R, Locht C, Mascart F, Mertsola J, Orfao A, Pantaleo G, Pollard AJ, Preston A, Read R, Sebo P, van Els C, Vecerek B, Londoño-Hayes P, de Groot R., PERISCOPE: road towards effective control of pertussis. Lancet Infect Dis 2018. S1473-3099: 30646-30647.
Michelet, X., Dyck, L., Hogan, A., Loftus, R. M., Duquette, D., Wei, K., Beyaz, S., Tavakkoli, A., Foley, C., Donnelly, R., O'Farrelly, C., Raverdeau, M., Vernon, A., Pettee, W., O'Shea, D., Nikolajczyk, B. S., Mills, K. H. G., Brenner, M. B., Finlay, D. and Lynch, L., Metabolic reprogramming of natural killer cells in obesity limits antitumor responses. Nat Immunol 2018. 19: 1330-1340
Flood, B., Manils, J., Nulty, C., Flis, E., Kenealy, S., Barber, G., Fay, J., Mills, K. H. G., Kay, E. W. and Creagh, E. M., Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis. Oncogene 2019. 38: 2658-2674.
Angiari, S., Runtsch, M. C., Sutton, C. E., Palsson-McDermott, E. M., Kelly, B., Rana, N., Kane, H., Papadopoulou, G., Pearce, E. L., Mills, K. H. G. and O'Neill, L. A. J., Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4(+) T Cell Pathogenicity and Suppresses Autoimmunity. Cell Metab 2020. 31: 391-405.e398.
Damron, F. H., Barbier, M., Dubey, P., Edwards, K. M., Gu, X. X., Klein, N. P., Lu, K., Mills, K. H. G., Pasetti, M. F., Read, R. C., Rohani, P., Sebo, P. and Harvill, E. T., Overcoming Waning Immunity in Pertussis Vaccines: Workshop of the National Institute of Allergy and Infectious Diseases. J Immunol 2020. 205: 877-882.
Hughes, M. M., Hooftman, A., Angiari, S., Tummala, P., Zaslona, Z., Runtsch, M. C., McGettrick, A. F., Sutton, C. E., Diskin, C., Rooke, M., Takahashi, S., Sundararaj, S., Casarotto, M. G., Dahlstrom, J. E., Palsson-McDermott, E. M., Corr, S. C., Mills, K. H. G., Preston, R. J. S., Neamati, N., Xie, Y., Baell, J. B., Board, P. G. and O'Neill, L. A. J., Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation. Cell Rep 2019. 29: 151-161.e155.
Locht, C., Carbonetti, N. H., Cherry, J. D., Damron, F. H., Edwards, K. M., Fernandez, R., Harvill, E. T., Hozbor, D., Mills, K. H. G., Rodriguez, M. E. and Mascart, F., Highlights of the 12th International Bordetella Symposium. Clin Infect Dis 2020. 71: 2521-2526.
Quinn, S. M., Cunningham, K., Raverdeau, M., Walsh, R. J., Curham, L., Malara, A. and Mills, K. H. G., Anti-inflammatory Trained Immunity Mediated by Helminth Products Attenuates the Induction of T Cell-Mediated Autoimmune Disease. Front Immunol 2019. 10: 1109.
Quinn, S. M., Raverdeau, M., McGinley, A. M. and Mills, K. H. G., Helminths products directly modulate T cells that mediate experimental autoimmune encephalomyelitis. Eur J Immunol 2019. 49: 1291-1294.
Raverdeau, M., Christofi, M., Malara, A., Wilk, M. M., Misiak, A., Kuffova, L., Yu, T., McGinley, A. M., Quinn, S. M., Massilamany, C., Reddy, J., Forrester, J. V. and Mills, K. H., Retinoic acid-induced autoantigen-specific type 1 regulatory T cells suppress autoimmunity. EMBO Rep 2019. 20.
Wilk, M. M., Borkner, L., Misiak, A., Curham, L., Allen, A. C. and Mills, K. H. G., Immunization with whole cell but not acellular pertussis vaccines primes CD4 T(RM) cells that sustain protective immunity against nasal colonization with Bordetella pertussis. Emerg Microbes Infect 2019. 8: 169-185.
Chasaide, C. N. and Mills, K. H. G., Next-Generation Pertussis Vaccines Based on the Induction of Protective T Cells in the Respiratory Tract. Vaccines (Basel) 2020. 8.
Edwards, S. C., Sutton, C. E., Ladell, K., Grant, E. J., McLaren, J. E., Roche, F., Dash, P., Apiwattanakul, N., Awad, W., Miners, K. L., Lalor, S. J., Ribot, J. C., Baik, S., Moran, B., McGinley, A., Pivorunas, V., Dowding, L., Macoritto, M., Paez-Cortez, J., Slavin, A., Anderson, G., Silva-Santos, B., Hokamp, K., Price, D. A., Thomas, P. G., McLoughlin, R. M. and Mills, K. H. G., A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans. J Exp Med 2020. 217
Finlay, C. M., Cunningham, K. T., Doyle, B. and Mills, K. H. G., IL-33-Stimulated Murine Mast Cells Polarize Alternatively Activated Macrophages, Which Suppress T Cells That Mediate Experimental Autoimmune Encephalomyelitis. J Immunol 2020. 205: 1909-1919.
Fitzgibbon, G. and Mills, K. H. G., The microbiota and immune-mediated diseases: Opportunities for therapeutic intervention. Eur J Immunol 2020. 50: 326-337.
McGinley, A. M., Sutton, C. E., Edwards, S. C., Leane, C. M., DeCourcey, J., Teijeiro, A., Hamilton, J. A., Boon, L., Djouder, N. and Mills, K. H. G., Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells. Immunity 2020. 52: 342-356.e346.
Zasłona, Z., Flis, E., Wilk, M. M., Carroll, R. G., Palsson-McDermott, E. M., Hughes, M. M., Diskin, C., Banahan, K., Ryan, D. G., Hooftman, A., Misiak, A., Kearney, J., Lochnit, G., Bertrams, W., Greulich, T., Schmeck, B., McElvaney, O. J., Mills, K. H. G., Lavelle, E. C., Wygrecka, M., Creagh, E. M. and O'Neill, L. A. J., Caspase-11 promotes allergic airway inflammation. Nat Commun 2020. 11: 1055.
Borkner, L., Curham, L. M., Wilk, M. M., Moran, B. and Mills, K. H. G., IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F(+) neutrophils. Mucosal Immunol 2021. 14: 1183-1202.
Cunningham, K. T., Finlay, C. M. and Mills, K. H. G., Helminth Imprinting of Hematopoietic Stem Cells Sustains Anti-Inflammatory Trained Innate Immunity That Attenuates Autoimmune Disease. J Immunol 2021. 206: 1618-1630.
Cunningham, K. T. and Mills, K. H. G., Trained Innate Immunity in Hematopoietic Stem Cell and Solid Organ Transplantation. Transplantation 2021. 105: 1666-1676.
Ryan, L. and Mills, K. H. G., Sex differences regulate immune responses in experimental autoimmune encephalomyelitis and multiple sclerosis. Eur J Immunol 2022. 52: 24-33.
Cervantes-Silva, M. P., Carroll, R. G., Wilk, M. M., Moreira, D., Payet, C. A., O'Siorain, J. R., Cox, S. L., Fagan, L. E., Klavina, P. A., He, Y., Drewinski, T., McGinley, A., Buel, S. M., Timmons, G. A., Early, J. O., Preston, R. J. S., Hurley, J. M., Finlay, D. K., Schoen, I., Javier Sánchez-García, F., Mills, K. H. G. and Curtis, A. M., The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing. Nat Commun 2022. 13: 7217.
Mills, K. H. G., Innate lymphoid cells recruit T cells to turn up the heat on tumors. Cancer Cell 2022. 40: 362-364.
Mills, K. H. G., IL-17 and IL-17-producing cells in protection versus pathology. Nat Rev Immunol 2023. 23: 38-54.
Cunningham, K. T. and Mills, K. H. G., Modulation of haematopoiesis by protozoal and helminth parasites. Parasite Immunol 2023: e12975.
Curham, L. M., Mannion, J. M., Daly, C. M., Wilk, M. M., Borkner, L., Lalor, S. J., McLoughlin, R. M. and Mills, K. H. G., Bystander activation of Bordetella pertussis-induced nasal tissue-resident memory CD4 T cells confers heterologous immunity to Klebsiella pneumoniae. Eur J Immunol 2023: e2250247.
Baran, M., Feriotti, C., McGinley, A., Carlile, S. R., Jiang, Z., Calderon-Gonzalez, R., Dumigan, A., Sá-Pessoa, J., Sutton, C. E., Kearney, J., McLoughlin, R. M., Mills, K. H. G., Fitzgerald, K. A., Bengeochea, J. A. and Bowie, A. G., PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection. Cell Rep 2023. 42: 112341.
Diallo, B. K., C, N. C., Wong, T. Y., Schmitt, P., Lee, K. S., Weaver, K., Miller, O., Cooper, M., Jazayeri, S. D., Damron, F. H. and Mills, K. H. G., Intranasal COVID-19 vaccine induces respiratory memory T cells and protects K18-hACE mice against SARS-CoV-2 infection. NPJ Vaccines 2023. 8: 68.
Moran, B., Smith, C. M., Zabarowski, A., Ryan, M., Karman, J., Dunstan, R. W., Smith, K. M., Hambly, R., Musilova, J., Petrasca, A., Fabre, A., O'Donnell, M., Hokamp, K., Mills, K. H. G., Housley, W. J., Winter, D. C., Kirby, B. and Fletcher, J. M., Targeting the NLRP3 inflammasome reduces inflammation in hidradenitis suppurativa skin. Br J Dermatol 2023.
Schmitt, P., Borkner, L., Jazayeri, S. D., McCarthy, K. N. and Mills, K. H.G., Nasal vaccines for pertussis. Curr Opin Immunol 2023. 84: 102355.
Ryan, T. A. J., Hooftman, A., Rehill, A. M., Johansen, M. D., Brien, E. C. O., Toller-Kawahisa, J. E., Wilk, M. M., Day, E. A., Weiss, H. J., Sarvari, P., Vozza, E. G., Schramm, F., Peace, C. G., Zotta, A., Miemczyk, S., Nalkurthi, C., Hansbro, N. G., McManus, G., O'Doherty, L., Gargan, S., Long, A., Dunne, J., Cheallaigh, C. N., Conlon, N., Carty, M., Fallon, P. G., Mills, K. H. G., Creagh, E. M., Donnell, J. S. O., Hertzog, P. J., Hansbro, P. M., McLoughlin, R. M., Wygrecka, M., Preston, R. J. S., Zasłona, Z. and O'Neill, L. A. J., Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon. Nat Commun 2023. 14: 3513.
Mills, K. H. G., How immunology can help reverse the pertussis vaccine failure. Nat Immunol 2023; 24(11):1779-1780.