Selected Publications
Michelet X, Dyck L, Hogan A, Loftus, Duquette D, Wei K, Beyaz S, Tavakkoli A, Foley C, Donnelly R, O’Farrelly C, Raverdeau M, Vernon A, Pettee W, O’Shea D, Nikolajczyk B, Mills KH, Brenner MB, Finlay D, and Lynch L. Metabolic reprogramming of natural killer cells in obesity limits anti-tumor responses. Nature Immunology, 2018 Dec;19(12):1330-1340
Wu D, Hu D, Argueta C, Yin C, Rabidou K, Chen H, Xu S, Zhang L, Yan G, Dong Z, Xu, Y Wang M, Shi G, Zhang S, Lian G, Murphy G, Adler G, Garg R, Yang P, Lan F, Lynch L, Li Y, Shi Y, Shi, YG. Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer. Nature 2018 Jul;559(7715):637-641.
Dyck, L. and Lynch, L. Cancer, obesity and immunometabolism;" Connecting the dots”. Cancer Letters, 2018 417, 2018, p11-20
Hong, S. and Song, W. and Zushin, P.-J.H. and Liu, B. and Jedrychowski, M.P. and Mina, A.I. and Deng, Z. and Cabarkapa, D. and Hall, J.A. and Palmer, C.J. and Aliakbarian, H. and Szpyt, J. and Gygi, S.P. and Tavakkoli, A. and Lynch, L. and Perrimon, N. and Banks, A.S., Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Molecular Metabolism, 2018, 12, p25-38
LaMarche, N.M. and Lynch, L. Adipose Dendritic Cells Come Out of Hiding. Cell Metabolism, 2018, 27, (3), p485-486
Dyck, L. and Lynch, L. New Job for NK Cells: Architects of the Tumor Microenvironment. Immunity, 2018 48, (1), 2018, p9-11
Kohlgruber, A.C. and Gal-Oz, S.T. and Lamarche, N.M. and Shimazaki, M. and Duquette, D. and Nguyen, H.N. and Mina, A.I. and Paras, T. and Tavakkoli, A. and Von Andrian, U. and Banks, A.S. and Shay, T. and Brenner, M.B. and Lynch, L. gd T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Nature Immunology, 2018, 19, (5),p464-474
Chang, S.K. and Kohlgruber, A.C. and Mizoguchi, F. and Michelet, X. and Wolf, B.J. and Wei, K. and Lee, P.Y. and Lynch, L. and Duquette, D. and Ceperuelo-Mallafré, V. and Banks, A.S. and Brenner, M.B., Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes. Journal of Clinical Investigation, 2017, 127, (9), p3300-3312
Pruss, H. and Tedeschi, A. and Thiriot, A. and Lynch, L. and Loughhead, S.M. and Stutte, S. and Mazo, I.B. and Kopp, M.A. and Brommer, B. and Blex, C. and Geurtz, L.-C. and Liebscher, T. and Niedeggen, A. and Dirnagl, U. and Bradke, F. and Volz, M.S. and DeVivo, M.J. and Chen, Y. and Von Andrian, U.H. and Schwab, J.M., Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex. Nature Neuroscience, 2017, 20, (11), p1549-1559
Nadine Assmann, Katie L. O'Brien, Raymond P. Donnelly, Lydia Dyck, Vanessa Zaiatz-Bittencourt, Róisín M. Loftus, Paul Heinrich, Peter J. Oefner, Lydia Lynch, Clair M. Gardiner, Katja Dettmer & David K. Finlay, Srebp-controlled glucose metabolism is essential for NK cell functional responses. Nature Immunology, 2017, 18, (11), p1197 - 1206
S. Boulenouar, X. Michelet, D. Duquette, D. Alvarez, A. Hogan, C. Dold, D. O’Connor, S. Stutte, A. Tavakkoli, D. Winters, M. Exley, D. O’Shea, M.B. Brenner, U. von Andrian, and L. Lynch. Adipose type one innate lymphoid cells regulate macrophage homeostasis through targeted cytotoxicity. Immunity 2017, 21, 46:273-286.
L. Lynch, A. Hogan, A. Ghosh, C. Lester, M. Corrigan, J. O’Connell, D. O’Shea and M. Brenner. GLP-1 therapy requires iNKT cells for weight loss, through iNKT-induced FGF21 and thermogenesis. In press, Cell Metabolism, 2016.
L. Lynch, X. Michelet, S. Zhang, P.J. Brennan, A. Moseman, C. Lester, G. Besra, E.E. Vomhof-Dekrey, M. Tighe, H. Koay, D.I. Godfrey, E.A. Leadbetter, D.B. Sant’Angelo, U. von Andrian, and M.B. Brenner. (2015) Regulatory iNKT cells lack PLZF and control Treg and macrophage homeostasis in adipose tissue. Nature Immunology, 16: 85-95.
A. Kohngruber, and L. Lynch. Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes. Current Diabetes Reports, 2015:15(11):92. doi: 10.1007/s11892-015-0670-x.
A. Longchamp, M. Tao, A. Bartelt, K. Ding, L. Lynch, C. Hine, J. Corpataux, B.S. Kristal, J.R. Mitchell, and C.K. Ozaki. Surgical injury induces local and distant adipose tissue browning. Adipocyte, 2015.
E. Carolan, LM Tobin, BA Mangan, MA Corrigan, G Gaoatswe, G Byrne, J Geoghegan, D Cody, J O'Connell, DC Winter, DG Doherty, L Lynch, D O'Shea, AE Hogan. Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity. Journal of Immunology, 2015; 194(12):5775-5780.
L. Lynch, E. Kim and M.B. Brenner. The transcriptional program of iNKT cells. Invited Review. Seminars in Immunology, 2015;27(1):26-32.
M. Exley, D. O’Shea, and L. Lynch. The interplay between the immune system and adipocytes in metabolic control. Invited Review. Journal of Endocrinology, 223:41-48. PMID: 25228503
L. Lynch. Adipose iNKT cells. Invited Review. (2014) Immunology, doi: 10.1111/imm.122692014. 2014. PMID: 24673647
G.A. Tynan, C. Hearnden, E. Oleszycka, C. Lyons, G. Coutts, J. O’Connell, M. Corrigan, L. Lynch, M. Campbell, JJ. Callanan, K. Mok, J. Geoghegan, C. O’Farrelly, SM. Allan, H. Roche, D. O’Shea, and E. Lavelle. Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1α-dependent inflammation. (2014) Diabetes. PMID: 24458363
A. Hogan, G. Gaoatswe, L. Lynch, M. Corrigan, C. Woods, J. O’Connell and D. O’Shea. Glucagon-like peptide-1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus. (2014) Diabetalogica, 57(4):781-4. PMID: 24362727
L. Lynch, M. Nowak, B. Varghese, A.E. Hogan, V. Toxavidis, S.P. Balk, D. O’Shea, C. O’Farrelly, and M.A. Exley. Adipose Tissue Invariant Natural Killer T Cells Protect Against Diet-Induced Obesity and Metabolic Disorder Through Regulation Cytokine Production. (2012) Immunity, 21;37(3):574-87. PMID: 22981538 *corresponding author
L. Szereday, E. Miko, M. Meggyes, A. Barakonyi, B. Farkas, J. Bodis, L. Lynch, Cliona O’Farrelly and J. Szekeres-Bartho. Decidual haematopoietic stem cells in first trimester pregnancy. (2012). American J Reproductive Immunology 67(1):9-16. PMID: 21682790
M.A. Exley, L. Lynch, B. Varghese, M. Nowak, N. Alatrakchi, and S. Balk. Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: reversing tumor-induced defects [review]. Invited Review: Clinical Applications of NKT cells. (2011) Clin Immunol. 140(2):184-95. PMCID: PMC3143311
J O’Connell, L Lynch, A Hogan, TJ Cawood, and D O’Shea. Preadipocyte factor-1 is associated with metabolic profile in severe obesity. (2011). Journal of Clinical Endocrinology and Metabolism, 96(4) 680-684. PMID: 21252254
A.E. Hogan, AM. Tobin, T. Ahern, M.A. Corrigan, G. Gaoatswe, R. Jackson, V. O’Reilly, L. Lynch, D.G Doherty, P.N. Moynagh, B. Kirby, J. O’Connell, and D. O’Shea. Glucagon like peptide -1 (GLP-1) and the regulation of human invariant natural killer T cells – lessons from obesity, diabetes and psoriasis. (2011). Diabetalogica, 54(11):2745-2754. PMID: 21744074
A.E. Hogan, M.A. Corrigan, V . O'Reilly, G. Gaoatswe, J. O'Connell, D.G. Doherty, L. Lynch, and D. O'Shea D. Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. (2011) Clin Immunol, 40(3):229-35. PMID: 21684213
A.M. Tobin, L. Lynch, B. Kirby, and C. O'Farrelly. Natural killer cells in psoriasis. Review. (2011) J. Innate Immunity, 3(4):403-410. PMID: 21613780
O'Shea D, Cawood TJ, O'Farrelly C, Lynch L. Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke. PLoS One. (2010), Jan 25;5(1):e8660. PMID: 20107494
M. Nowak, L. Lynch, S. Yue, A. Ohta, M. Sitkovsky, S.P. Balk, and M.A. Exley. The A2aR adenosine receptor controls cytokine production in iNKT cells. (2010). Eur J Immunol, 40(3):682-687. PMID: 20039304
J.J. O’Connell, L. Lynch, T.J. Cawood and D. O’Shea. The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity. (2010). PLoS One, e9997. PMID: 20376319
A. O’Donovan, B.M. Hughes, G.M. Slavich, L. Lynch, M.T. Cronin, C. O’Farrelly, and K. Malone. Clinical anxiety and interleukin 6: Evidence for specificity in emotion biology relationships. (2010) Brain Behav Immun, 24(7):1074-7. PMID: 20227485
L. Lynch, D O’ Shea, D.C. Winter, J. Geoghegan, D.G. Doherty and C.O’Farrelly. Invariant NKT Cells and CD1d-positive Cells Amass in Human Omentum and are Depleted in Patients with Cancer and Obesity. (2009) Eur. J. Immunology, 39(7):1893-1901. PMID: 19585513
L. Lynch, J. O’Connell, A. Kwasnik, T. Cawood, C.O’ Farrelly and D. O’Shea. Are natural killer cells protecting the metabolically healthy obese? (2009) Obesity (Silver Spring),17:601-605. PMID: 19238145
E. McGrath, E.J. Ryan, L. Lynch, L. Golden-Mason, C. O’Herlihy, M. Eogan, and C. O’Farrelly. Cycle-Related Changes in Endometrial Natural Killer Cell Expression of CD94, CD158a and CD158b are Associated with Infertility (2008). American Journal of Reproduction, 61:265-276. PMID: 19260857
L. Lynch, M. Eogan, L. Golden-Mason, C. O’Herlihy and C. O’Farrelly. Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility? (2006). Human Reproduction, 22:919-26. PMID: 17208945 This publication was been nominated for the 9th Royan International Research Award.
L. Lynch, D. O’Donoghue, J. Dean, J. O’Sullivan, C. O’Farrelly and L.Golden-Mason. Detection and Characterization of Haematopoietic Stem Cells in the Human Small Intestine. (2006) Journal of Immunology, 176: 5199-5204. PMID: 16621984
BOOK CHAPTERS:
M.A. Exley, L. Lynch, M. Nowak. NKT Cells of Cancer Patients and How Models Can Inform Therapeutic Plans (2012) [chapter]. In: Natural Killer T cells. Balancing the Regulation of Tumor Immunity. Terabe M, Berzofsky JA, editors. New York: Springer; 2012. pp. 129-52.