Publications
Pubmed: https://www.ncbi.nlm.nih.gov/pubmed/?term=loane+dj
Google Scholar: https://scholar.google.com/citations?user=dznbdfYAAAAJ&hl=en
Selected Original Research Articles:
Ritzel RM, Li Y, Jiao Y, Lei Z, Doran SJ, He J, Shahror RA, Henry RJ, Khan R, Tan C, Liu S, Stoica BA, Faden AI, Szeto G, Loane DJ*, Wu J*. Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration. Science Advances 9:eadd1101. 2023. (*co-senior author).
Hegdekar N, Sarkar C, Bustos S, Ritzel RM, Hanscom M, Ravishankar P, Philkana D, Wu J, Loane DJ, Lipinski MM. Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes. Autophagy Jan 18:1-19. doi: 10.1080/15548627.2023.2167689, 2023.
Barrett JP, Knoblach SM, Bhattacharya S, Gordish-Dressman H, Stoica BA, Loane DJ. Traumatic Brain Injury Induces cGAS Activation and Type I Interferon Signaling in Aged Mice. Frontiers in Immunology 12:710608, 2021.
Hanscom M, Loane DJ, Aubretch T, Leser J, Molesworth K, Hedgekar N, Ritzel RM, Abulwerdi G, Shea-Donohue T, Faden AI. Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits. Journal of Neuroinflammation 18(1):24. 2021.
Doran SJ, Henry RJ, Shirey KA, Barrett JP, Ritzel RM, Lai W, Blanco JC, Faden AI, Vogel SN, Loane DJ. Early or Late Bacterial Lung Infection Increases Mortality After Traumatic Brain Injury in Male Mice and Chronically Impairs Monocyte Innate Immune Function. Critical Care Medicine 48(5):e418-e428, 2020.
Henry RJ, Ritzel RM, Barrett JP, Doran SJ, Jiao Y, Leach JB, Szeto GL, Wu J, Stoica BA, Faden AI, Loane DJ. Microglial Depletion with CSF1R Inhibitor During Chronic Phase of Experimental Traumatic Brain Injury Reduces Neurodegeneration and Neurological Deficits. Journal of Neuroscience 40:2960-2974, 2020.
Barrett JP, Henry RJ, Shirey KA, Doran SJ, Makarevich OD, Ritzel RM, Meadows VA, Vogel SN, Faden AI, Stoica BA, Loane DJ. Interferon-β Plays a Detrimental Role in Experimental Traumatic Brain Injury by Enhancing Neuroinflammation That Drives Chronic Neurodegeneration. Journal of Neuroscience 40:2357-2370, 2020.
Bhat SA, Henry RJ, Blanchard AC, Stoica BA, Loane DJ*, Faden AI*. Enhanced Akt/GSK-3β/CREB signaling mediates the anti-inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice. Journal of Neurochemistry, Jan 11:e14954. doi: 10.1111/jnc.14954. 2020 (*co-senior author).
Ritzel RM, Doran SJ, Glaser EP, Meadows V, Faden AI, Stoica BA, Loane DJ. Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes following acute traumatic brain injury in mice. Neurobiology of Aging. 77:194-206, 2019.
Doran SJ, Ritzel RM, Glaser EP, Henry RJ, Faden AI, Loane DJ. Sex Differences in Acute Neuroinflammation after Experimental Traumatic Brain Injury Are Mediated by Infiltrating Myeloid Cells. Journal of Neurotrauma. 36:1040-1053, 2019.
Henry RJ, Doran SJ, Barrett JP, Meadows VE, Sabirzhanov B, Stoica BA, Loane DJ*, Faden AI*. Inhibition of miR-155 Limits Neuroinflammation and Improves Functional Recovery After Experimental Traumatic Brain Injury in Mice. Neurotherapeutics. 16:216-230, 2019 (*co-senior author).
Ritzel RM, Doran S, Barrett JP, Henry RJ, Ma EL, Faden AI, Loane DJ. Chronic Alterations in Systemic Immune Function After Traumatic Brain Injury. Journal of Neurotrauma. 35:1419-1436, 2018.
Kumar A, Stoica BA, Loane DJ, Yang M, Abulwerdi G, Khan N, Kumar A, Thom SR, Faden AI. Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury. Journal of Neuroinflammation 14:47, 2017.
Villapol S, Loane DJ, Burns MP. Sexual dimorphism in the inflammatory response to traumatic brain injury. Glia 65:1423-1438, 2017.
Barrett JP, Henry RJ, Villapol S, Kumar A, Stoica BA, Burns MP, Faden AI, Loane DJ. NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for acute brain injury. Journal of Neuroinflammation 14:65, 2017.
Ma EL, Smith AD, Desai N, Cheung L, Hanscom M, Stoica BA, Loane DJ, Shea-Donohue T, Faden AI. Bidirectional brain-gut interactions and chronic pathological changes after traumatic brain injury in mice. Brain Behavior and Immunity 66:56-69, 2017.
Kumar A, Barrett JP, Alvarez M, Stoica BA, Faden AI, Loane DJ. NOX2 drives M1-like microglia/macrophage activation and neurodegeneration following experimental traumatic brain injury. Brain Behavior and Immunity 58:291-309, 2016.
Kumar A, Alvarez M, Stoica BA, Faden AI, Loane DJ. Macrophage/microglia polarization dynamics following traumatic brain injury. Journal of Neurotrauma 33:1732-1750, 2016.
Loane DJ, Kumar A, Stoica BA, Cabatbat R, Faden AI. Progressive neurodegeneration after experimental brain trauma; association with chronic microglial activation. Journal of Neuropathology and Experimental Neurology. 73 14-29, 2014.
Kumar A, Stoica BA, Burns MP, Faden AI, Loane DJ. Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states. Neurobiology of Aging. 34 1397-411, 2013.
Byrnes KR*, Loane DJ*, Stoica BA, Zhang Z, Faden AI. Delayed mGluR5 activation reduces chronic inflammation and neurodegeneration after brain trauma. Journal of Neuroinflammation. 9 43, 2012 (*co-first author).
Loane DJ, Pocivavsek A, Moussa CE-H, Thompson R, Matsuoka Y, Faden AI, Rebeck GW, Burns MP. APP secretases as therapeutic targets for traumatic brain injury. Nature Medicine. 15 377-9, 2009.
Loane DJ, Stoica BA, Pajoohesh-Ganji A, Byrnes KR, Faden AI. Activation of metabotropic glutamate receptor 5 (mGluR5) modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase. Journal of Biological Chemistry. 284 15629-15639, 2009.
Loane DJ, Deighan BF, Clarke RM, Griffin RJ, Lynch AM, Lynch MA. Interleukin-4 mediates the neuroprotective effects of rosiglitazone in the aged brain. Neurobiology of Aging. 30 920-31, 2009.
Other Articles:
Grovola MR, von Reyn C, Loane DJ, Cullen DK. Understanding microglial responses in large animal models of traumatic brain injury: an underutilized resource for preclinical and translational research.
Journal of Neuroinflammation 20(1):67, 2023.
Hanscom M, Loane DJ, Shea-Donohue T. Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury. Journal of Clinical Investigation 131(12):e143777, 2021.
Sun M, McDonald SJ, Brady RD, Collins-Praino L, Yamakawa GR, Monif M, O'Brien TJ, Cloud GC, Sobey CG, Mychasiuk R, Loane DJ, Shultz SR. The need to incorporate aged animals into the preclinical modeling of neurological conditions. Neuroscience & Biobehavioral Reviews, 109:114-128, 2020.
Loane DJ, Faden AI. Traumatic meningeal injury and repair mechanisms. Nature Immunology. 19:431-432, 2018.
Simon DW, McGeachy M, Bayir H, Clark RSB, Loane DJ, Kochanek PM. The far-reaching scope of neuroinflammation after traumatic brain injury. Nature Reviews Neurology 13:171-191, 2017.
Loane DJ, Kumar A. Microglia in the TBI Brain: The Good, The Bad, and The Dysregulated. Experimental Neurology 275 Pt 3:316-27, 2016.
Faden AI, Wu J, Stoica BA, Loane DJ. Progressive inflammatory-mediated neurodegeneration after traumatic brain or spinal cord injury. British Journal of Pharmacology 173 681-91, 2016.
Faden AI, Loane DJ. Chronic Neurodegeneration after TBI: Alzheimer Disease, Chronic Traumatic Encephalopathy or Persistent Neuroinflammation? Neurotherapeutics. 12 143-50, 2015.
Kumar A, Loane DJ. Neuroinflammation after traumatic brain injury: Opportunities for therapeutic intervention. Brain Behavior and Immunity. 26 1191-201, 2012.
Loane DJ, Faden AI. Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies. Trends in Pharmacological Sciences. 31 596-604, 2010.
Loane DJ, Byrnes KR. Role of microglia in neurotrauma. Neurotherapeutics. 7 366-77, 2010.