Publications
Campiani, G., Khan, T., Ulivieri, C., Staiano, L., Papulino, C., Magnano, S., Nathwani, S., Ramunno, A., Lucena-Agell, D., Relitti, N. and Federico, S., Pozzetti, L., Carullo, G., Casagni, A., Brogi, S., Vanni, F., Galatello, P., Ghanim, M., McCabe, N., Lamponi, S., Valoti, M., Ibrahim, O., O'Sullivan, J., Turkington, R., Kelly, V.P., VanWemmel, R., Fernando Díaz, J., Gemma, S., Zisterer, D., Altucci, L., De Matteis, A., Butini, S., Benedetti, R. 2022. Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy. European Journal of Medicinal Chemistry, 235, p.114274.
McDonnell, C.M., Ghanim, M., Southern, J.M., Kelly, V.P. and Connon, S.J., 2022. De-novo designed β-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P. Bioorganic & Medicinal Chemistry Letters, p.128545.
Doran, C.G., Sugisawa, R., Carty, M., Roche, F., Fergus, C., Hokamp, K., Kelly, V.P. and Bowie, A.G., 2021. Next generation SARM1 knockout and epitope tagged CRISPR-Cas9-generated isogenic mice reveal that SARM1 does not participate in regulating nuclear transcription, despite confirmation of protein expression in macrophages. bioRxiv.
Ghanim M, Relitti N, McManus G, Butini S, Cappelli A, Campiani G, Mok KH, Kelly VP. 2021. Sci Rep. A non-toxic, reversibly released imaging probe for oral cancer that is derived from natural compounds. 11(1):14069.
Fergus, C., Al-Qasem, M., Cotter, M., McDonnell, C.M., Sorrentino, E., Chevot, F., Hokamp, K., Senge, M.O., Southern, J.M., Connon, S.J. and Kelly, V.P., 2021. The human tRNA-guanine transglycosylase displays promiscuous nucleobase preference but strict tRNA specificity. Nucleic acids research, 49(9), pp.4877-4890.
van Wijk, K., Akabane, T., Kimura, T., Saitoh, S., Okano, S., Kelly, V.P., Takagi, M., Kodama, K., Takahashi, K., Tanaka, T. and Nakajima, M., 2021. Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver. Archives of Biochemistry and Biophysics, 697, p.108721. DOI: 10.1016/j.abb.2020.108721
Saraswati, A.P., Relitti, N., Brindisi, M., Osko, J.D., Chemi, G., Federico, S., Grillo, A., Brogi, S., McCabe, N.H., Turkington, R.C. and Ibrahim, O., O’Sullivan, J., Lamponi, S., Ghanim, M., Kelly, V.P., Zisterer, D., Amet, R., Hannon Barroeta, P., Vanni, F., Ulivieri, C., Herp, D., Sarno, F., Di Costanzo, A., Saccoccia, F., Ruberti, G., Jung, M., Altucci, L., Gemma, S., Butini, S., Christianson, D.W., Campiani, G. 2020. Spiroindoline-capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis and Biological Evaluation. ACS Medicinal Chemistry Letters. DOI: 10.1021/acsmedchemlett.0c00395
Hayes, P., Fergus, C., Ghanim, M., Cirzi, C., Burtnyak, L., McGrenaghan, C.J., Tuorto, F., Nolan, D.P. and Kelly, V.P. (2020) Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells. Nutrients, 12(3), p.871.
Alqasem, M.A., Fergus, C., Southern, J.M., Connon, S.J. and Kelly, V.P (2020). The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA via a sequential bi–bi mechanism. Chemical Communications, 56(27), pp.3915-3918.
Browning, J., Rooney, M., Hams, E., Takahashi, S., Mizuno, S., Sugiyama, F., Fallon, P.G. and Kelly, V.P., (2020) Highly efficient CRISPR-targeting of the murine Hipp11 intergenic region supports inducible human transgene expression. Molecular biology reports, 47(2), pp.1491-1498.
Müller M, Legrand C, Tuorto F, Kelly VP, Atlasi Y, Lyko F, Ehrenhofer-Murray AE. (2019) Queuine links translational control in eukaryotes to a micronutrient from bacteria. Nucleic Acids Res. 10.1093/nar/gkz063.
Galván-Peña S, Carroll RG, Newman C, Hinchy EC, Palsson-McDermott E, Robinson EK, Covarrubias S, Nadin A, James AM, Haneklaus M, Carpenter S, Kelly VP, Murphy MP, Modis LK, O'Neill LA. (2019) Malonylation of GAPDH is an inflammatory signal in macrophages. Nat Commun. 10(1):338. doi: 10.1038/s41467-018-08187-6.
Chang Y.-H., Nishimura S., Oishi H., Kelly V.P., Kuno A., Takahashi S., TRMT2A is a novel cell cycle regulator that suppresses cell proliferation, Biochemical and Biophysical Research Communications, 508, (2), 2019, p410 - 415, p410-415
Rooney M.F., Hill E.W., Kelly V.P., Porter R.K., The "speed gene" effect of myostatin arises in Thoroughbred horses due to a promoter proximal SINE insertion, PLoS ONE, 13, (10), 2018
Saitoh S, Okano S, Nohara H, Nakano H, Shirasawa N, Naito A, Yamamoto M, Kelly VP, Takahashi K, Tanaka T, Nakajima M, Nakajima O., 5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice, PLoS One, 13, (1), 2018, p0189593
Jantsch, M.F., Quattrone, A., O'Connell, M., (...), Ule, J., Fray, R., Positioning Europe for the EPITRANSCRIPTOMICS challenge, RNA Biology, 2018, p1-3
Varghese S, Cotter M, Chevot F, Fergus C, Cunningham C, Mills KH, Connon SJ, Southern JM, Kelly VP., In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis, Nucleic Acids Research, 45, (4), 2017, p2029-2039
Williams JM, Bezak T, Das M, Ning Z, Lucking EF, Kelly VP, Harrison P, Young P, O'Connell MJ, Dockery P, O'Halloran KD, Moore T, Psg22 null mouse embryos develop normally under normoxic and hypoxic conditions of pregnancy, Science Matters, 10, (19185), 2016
Fergus, C., Barnes, D., Alqasem, M.A., Kelly, V.P, The queuine micronutrient: Charting a course from microbe to man, Nutrients, 7,(4), 2015, p2897-2929
Tannahill, GM, Curtis, AM, Adamik, J, Palsson-McDermott, EM, McGettrick, AF, Goel, G, Frezza, C, Bernard, NJ, Kelly, B, Foley, NH, Zheng, L, Gardet, A, Tong, Z, Jany, SS, Corr, SC, Haneklaus, M, Caffrey, BE, Pierce, K, Walmsley, S, Beasley, FC, Cummins, E, Nizet, V, Whyte, M, Taylor, CT, Lin, H, Masters, SL, Gottlieb, E, Kelly, VP, Clish, C, Auron, PE, Xavier, RJ, O'Neill, LAJ, Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha, NATURE, 496, (7444), 2013, p238
Enhancing the Teaching and Learning of Laboratory Sciences through a Virtual Learning Environment. in, editor(s)Marcus-Quinn A, Bruen C, Allen M, Dundon A, Diggins Y, The Digital Learning Revolution in Ireland : Case Studies from the National Learning Resources Service, Cambridge, UK, Cambridge Scholars Publishing, 2012, pp181 - 194, [Robinson GA, Nic A' Bháird N, Kelly VP]
Rakovich T, Boland C, Bernstein I, Chikwana VM, Iwata-Reuyl D, Kelly VP, Queuosine deficiency in eukaryotes compromises tyrosine production through increased tetrahydrobiopterin oxidation, The Journal of Biological Chemistry, 286, (22), 2011, p19354-19363
Kawatani Y, Suzuki T, Shimizu R, Kelly VP, Yamamoto M., Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia, Blood, 20, (1), 2011, p986 - 996
Rakovich A, Rakovich T, Kelly VP, Lesnyak V, Eychmüller A, Rakovich YP, Donegan JF, Photosensitizer methylene blue-semiconductor nanocrystals hybrid system for photodynamic therapy, Journal of nanoscience and nanotechnology, 10, (4), 2010, p2656-2662
Rakovich A, Savateeva D, Rakovich T, Donegan JF, Rakovich YP, Kelly VP, Lesnyak V, Eychmüller A, CdTe Quantum Dot/Dye Hybrid System as Photosensitizer for Photodynamic Therapy, Nanoscale Research Letters, 1931, 2010, p7573 - 7585
MacLeod AK, Kelly VP, Higgins LG, Kelleher MO, Price SA, Bigley AL, Betton GR, Hayes JD., Expression and localization of rat aldo-keto reductases and induction of the 1B13 and 1D2 isoforms by phenolic antioxidants, Drug Metabolism & Disposition, 38, (2), 2010, p341 - 346
Chen Yi-C, Kelly VP, Stachura SV, Garcia GA. , Characterization of the human tRNA-guanine transglycosylase: confirmation of the heteromeric subunit structure, RNA, 16, (5), 2010, p958-968
Boland C, Hayes PA, Santa-Maria I, Nishimura S and Kelly VP, Queuosine formation in eukaryotic tRNA occurs via a mitochondrial localized heteromeric transglycoslase. Journal of Biological Chemistry, 284, (27), 2009, p18218-18227
Suzuki T, Kelly VP, Motohashi H, Nakajima O, Takahashi S, Nishimura S, Yamamoto M, Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2, Journal of Biological Chemistry, 283, (4), 2008, p2021-2030
Arai T, Kelly VP, Minowa O, Noda T, Nishimura S., The study using wild-type and Ogg1 knockout mice exposed to potassium bromate shows no tumor induction despite an extensive accumulation of 8-hydroxyguanine in kidney DNA, Toxicology, 221, 2006, p179 - 186
Kelly VP, Takafumi S, Nakajima O, Arai T, Tamai Y, Takahashi S, Nishimura S, Yamamoto M., The distal sequence element of the selenocysteine tRNA gene is a tissue dependant enhancer essential for mouse embryogenesis, Mol. Cell Biol., 25, 2005, p3658 - 3669
Kobayashi T, Takimura T, Sekine R, Kelly VP, Kamata K, Sakamoto K, Nishimura S, Yokoyama S., Structural snapshots of the KMSKS loop rearrangement for amino acid activation by bacterial tyrosyl-tRNA synthetase, J. Mol. Biol., 346, (1), 2005, p105 - 117
Kobayashi T, Sakamoto K, Takimura T, Sekine R, Kelly VP, Kamata K, Nishimura S, Yokoyama S., Structural basis of nonnatural amino acid recognition by an engineered aminoacyl-tRNA synthetase for genetic code expansion, Proceedings of the National Academy of Sciences of the United States of America, 102, (5), 2005, p1366 - 1371
Itoh K, Mochizuki M, Ishii Y, Ishii T, Shibata T, Kawamoto Y, Kelly VP, Sekizawa K, Uchida K, Yamamoto M., Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-prostaglandin J2, Molecular and Cellular Biology, 24, 2004, p36 - 45
Aflatoxin Aldehyde Reductases in, editor(s)Penning TM, Petrash JM , Aldo-Keto Reductases and toxicant metabolism, Oxford, UK, Oxford University Press, 2004, pp155 - 170, [Kelly VP, O'Connor T, Ellis EM, Ireland LS, Slattery CM, Sherratt PJ, Crouch DH, Cavin C, Schilter B, Gallina A, Hayes JD]
Arai T, Kelly VP, Komoro K, Minowa O, Noda T, Nishimura S., Cell proliferation in liver of Mmh/Ogg1-deficient mice enhances mutation frequency because of the presence of 8-hydroxyguanine in DNA, Cancer Research, 63, 2003, p4287 - 4292
Kelly VP, Sherratt PJ, Crouch DH and Hayes JD, Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct class of aldo-keto reductase 7 family proteins, Biochemical Journal, 366, (3), 2002, p847 - 861
Arai T, Kelly VP, Minowa O, Noda T and Nishimura S, High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress, Carcinogenesis, 23, 2002, p2005 - 2010
Grant A, Staffas L, Mancowiz L, Kelly VP, Manson MM, DePierre JW, Hayes JD, Ellis EM, Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility, Biochemical Pharmacology, 62, (11), 2001, p1511 - 1519
Kelly VP, Ellis EM, Manson MM, Chanas S A, Graeme JM, McLeod R, Neal GE and Hayes JD, Chemoprevention of aflatoxin B1 hepato-carcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of Aflatoxin B1-Aldehyde Reductase, the Glutathione S-Transferase A5 and P1 Subunits and NAD(P)H:Quinone Oxidoreductase in Rat Liver, Cancer Research, 60, (4), 2000, p957 - 969
Kelly VP, Ireland LS, Ellis EM and Hayes JD, Purification from rat liver of a novel constitutively expressed member of the aldo-keto reductase 7 family that is widely distributed in extra-hepatic tissues, Biochemical Journal, 348, (2), 2000, p389 - 400
Kelly VP, Purification, cloning and characterisation of novel members of the Aldo-Keto Reductase 7 Family, 1999
Kelly VP and O'Neill LA, Sustained activation of NF kappa B and transient I kappa B alpha degradation induced by tumour necrosis factor in 1321N1 human astrocytoma, Biochemical Society Transactions, 23, (4), 1995, p597S - 597S