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Research Articles

  1. Hankir MK, Kovatcheva-Datchary P, Springer R, Hoffmann A, Vogel J, Seyfried F, Arora T. Gut Microbiota Contribution to Weight-Independent Glycemic Improvements after Gastric Bypass Surgery. Microbiology Spectrum. 2023 11(3): e0510922. doi: 10.1128/spectrum.05109-22.
  2. Seyfried F, Springer R, Hoffmann A, Gruber M, Otto C, Schlegel N, Hankir MK. Gastric bypass surgery weight loss-independently induces gut Il-22 release in association with improved glycemic control in obese Zucker fatty rats. Metabolism Open. 2022 17:100212. doi: 10.1016/j.metop.2022.100212.
  3. Hankir MK, Langseder T, Bankoglu EE, Ghoreishi Y, Dischinger U, Kurlbaum M, Kroiss M, Otto C, le Roux CW, Arora T, Seyfried F, Schlegel N. Simulating the Post-gastric Bypass Intestinal Microenvironment Uncovers a Barrier-Stabilizing Role for FXR. iScience. 2020 23(12):101777. doi: 10.1016/j.isci.2020.101777.
  4. Seyfried F, Hoffmann A, Rullmann M, Schlegel N, Otto C, Hankir MK. Weight loss from caloric restriction vs Roux-en-Y gastric bypass surgery differentially regulates systemic and portal vein GDF15 levels in obese Zucker fatty rats. Physiology and Behaviour. 2021 240:113534. doi: 10.1016/j.physbeh.2021.113534.
  5. Hankir MK, Rullmann M, Seyfried F, Preusser S, Poppitz S, Heba S, Gousias K, Hoyer J, Schütz T, Dietrich A, Müller K, Pleger B. Roux-en-Y gastric bypass surgery progressively alters radiologic measures of hypothalamic inflammation in obese patients. JCI Insight. 2019 4(19): e131329. doi: 10.1172/jci.insight.131329
  6. Hankir MK, Kranz M, Keipert S, Weiner J, Andreasen SG, Kern M, Patt M, Klöting N, Heiker JT, Brust P, Hesse S, Jastroch M, Fenske WK. Dissociation Between Brown Adipose Tissue 18F-FDG Uptake and Thermogenesis in Uncoupling Protein 1-Deficient Mice. Journal of Nuclear Medicine. 2017 58(7):1100-1103. doi: 10.2967/jnumed.116.186460.
  7. Hankir MK, Seyfried F, Hintschich CA, Diep TA, Kleberg K, Kranz M, Deuther-Conrad W, Tellez LA, Rullmann M, Patt M, Teichert J, Hesse S, Sabri O, Brust P, Hansen HS, de Araujo IE, Krügel U, Fenske WK. Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats. Cell Metabolism. 2017 25(2):335-344. doi: 10.1016/j.cmet.2016.12.006.
  8. Hankir MK, Kranz M, Gnad T, Weiner J, Wagner S, Deuther-Conrad W, Bronisch F, Steinhoff K, Luthardt J, Klöting N, Hesse S, Seibyl JP, Sabri O, Heiker JT, Blüher M, Pfeifer A, Brust P, Fenske WK. A novel thermoregulatory role for PDE10A in mouse and human adipocytes. EMBO Molecular Medicine. 2016 8(7):796-812. doi: 10.15252/emmm.201506085
  9. Smith MA, Katsouri L, Irvine EE, Hankir MK, Pedroni SM, Voshol PJ, Gordon MW, Choudhury AI, Woods A, Vidal-Puig A, Carling D, Withers DJ. Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice. Cell Reports. 2015 11(3):335-43. doi: 10.1016/j.celrep.2015.03.029.
  10. Frost G, Sleeth ML, Sahuri-Arisoylu M, Lizarbe B, Cerdan S, Brody L, Anastasovska J, Ghourab S, Hankir MK, Zhang S, Carling D, Swann JR, Gibson G, Viardot A, Morrison D, Louise Thomas E, Bell JD. The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism.  Nature Communications. 2014 5:3611. doi: 10.1038/ncomms4611
  11. Hankir MK, Parkinson JR, Bloom SR, Bell JD. The effects of glutamate receptor agonists and antagonists on mouse hypothalamic and hippocampal neuronal activity shown through manganese enhanced MRI.  Neuroimage. 2012 59(2):968-78. doi: 10.1016/j.neuroimage.2011.08.063.
  12. Hankir MK, Parkinson JR, Minnion JS, Addison ML, Bloom SR, Bell JD. Peptide YY 3-36 and pancreatic polypeptide differentially regulate hypothalamic neuronal activity in mice in vivo as measured by manganese-enhanced magnetic resonance imaging.  Journal of Neuroendocrinology. 2011 23(4):371-80. doi: 10.1111/j.1365-2826.2011.02111. x.

Review/Opinion Articles

  1. Hankir MK. Creating a picture of brown fat with creatine-CEST. Trends in Endocrinology and Metabolism. 2024 S1043-2760(24)00252-2. doi: 10.1016/j.tem.2024.08.013.
  2. Hankir MK. Gut microbiota turn up the heat after bariatric surgery. Cell Stress. 2023 7(10):90-94. doi: 10.15698/cst2023.10.290.
  3. Hankir MK. A purinergic call to arms from dying brown adipocytes. Cell Stress. 2022 6(7):68-71. doi: 10.15698/cst2022.07.269.
  4. Hankir MK, Hoffmann A, Seyfried F. Starving cancer into submission by activating BAT. Cell Metabolism. 2022 34(10):1428-1430. doi: 10.1016/j.cmet.2022.09.009.
  5. Hankir MK. Building and breaking the gut barrier with bariatric surgery. Cell Stress. 2021 6(2):17-20. doi: 10.15698/cst2022.02.263.
  6. Hankir MK. A sympathetic gut connection drives the metabolic benefits of Roux-en-Y gastric bypass. Cell Stress. 2020 4(12):265-269. doi: 10.15698/cst2020.12.236
  7. Hankir MK, Seyfried F. Do Bariatric Surgeries Enhance Brown/Beige Adipose Tissue Thermogenesis?  Frontiers in Endocrinology. 2020 11:275. doi:10.3389/fendo.2020.00275.
  8. Hankir MK, Seyfried F. Partial Leptin Reduction: An Emerging Weight Loss Paradigm.  Trends in Endocrinology and Metabolism. 2020 31(6):395-397. doi: 10.1016/j.tem.2020.03.001.
  9. Hankir MK, Al-Bas S, Rullmann M, Chakaroun R, Seyfried F, Pleger B. Homeostatic, reward and executive brain functions after gastric bypass surgery. Appetite. 2020 146:104419. doi: 10.1016/j.appet.2019.104419.
  10. Hankir MK, Klingenspor M. Brown adipocyte glucose metabolism: a heated subject. EMBO Reports. 2018 19(9): e46404. doi: 10.15252/embr.201846404.
  11. Hankir MK, Seyfried F, Miras AD, Cowley MA. Brain Feeding Circuits after Roux-en-Y Gastric Bypass. Trends in Endocrinology and Metabolism. 2018 29(4):218-237. doi: 10.1016/j.tem.2018.01.009.
  12. Hankir MK, Cowley MA, Fenske WK. A BAT-Centric Approach to the Treatment of Diabetes: Turn on the Brain. Cell Metabolism. 2016 24(1):31-40. doi: 10.1016/j.cmet.2016.05.003.