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School of Biochemistry and Immunology

You are here Research > Groups > Translational Immunology > Publications

Selected Publications

Publications (H-INDEX 21)

  1. Kelly A, Fahey R, Fletcher JM, Keogh C, Carroll AG, Siddachari R, Geoghegan J, Hegarty JE, Ryan  EJ, O'Farrelly C. CD141+myeloid dendritic cells are enriched in healthy human liver. J Hepatol. Aug 2013.

  2. O'Connell K, Kelly S, Kinsella K, Jordan S, Kenny O, Murphy D, Heffernan E, O'Laoide R, O'Shea D, McKenna C, Cassidy L, Fletcher J, Walsh C, Brady J, McGuigan C, Tubridy N, Hutchinson M. Dose-related effects of vitamin D on immune responses in patients with clinically isolated syndrome and healthy control participants: study protocol for an exploratory randomized double-blind placebo-controlled trial. Trials. 2013 Aug 27;14:272.

  3. Aideen C Allen, Siobhan Kelly, Sharee A Basdeo, Katie Kinsella, Keith J Mulready, Kingston HG Mills, Niall Tubridy, Cathal Walsh, Jennifer J Brady, Michael Hutchinson, Jean M Fletcher. A pilot study of the immunological effects of high dose vitamin D in healthy volunteers. Mult Scler. 2012. 18(12):1797-800.

  4. Sweeney CM, Lonergan R, Basdeo SA, Dungan LS, Kinsella K, Costelloe L, Tubridy N, Mills KHG and JM Fletcher. IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells. Brain Behav Imm. 2011 25(6):1170-81.

  5. Stephen J. Lalor, Lara S. Dungan, Caroline E. Sutton, Sharee A. Basdeo, JM Fletcher and Kingston H.G. Mills. Caspase-1 processed cytokines IL-1β and IL-18 promote IL-17-production by γδ and CD4 T cells that mediate autoimmunity. J Immunol. 2011 15;186(10):5738-48.

  6. O'Brien M, Lonergan R, Costelloe L, O'Rourke K, Fletcher JM, Kinsella K, Sweeney C, Antonelli G, Mills KHG, O'Farrelly C, Hutchinson M and Tubridy N. OAS1: a multiple sclerosis susceptibility gene which influences disease severity. Neurology 20103;75(5):411-8.

  7. Hoare M, Gelson WT, Das A, Fletcher JM, Davies SE, Curran MD, Vowler SL, Maini MK, Akbar AN, Alexander GJ. CD4+ T-lymphocyte telomere length is related to fibrosis stage, clinical outcome and treatment response in chronic hepatitis C virus infection. J Hepatol. 2010 53(2):252-60.

  8. Fletcher JM, Lonergan R, Costelloe L, Kinsella K, Moran B, O'Farrelly C, Tubridy N, Mills KH. CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis. J Immunol 2009; 183(11):7602-10.

  9. Rowan AG, Fletcher JM, Ryan EJ, Hegarty JE, O’Farrelly C and Mills KHG. Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-β. J Immunol. 2008; 181(7):4485-94

  10. Jarnicki AG, Conroy H, Brereton C, Donnelly G, Toomey D, Walsh K, Sweeney C, Leavy O, Fletcher JM, Lavelle EC, Dunne P, Mills KH. Attenuating regulatory T cell induction by TLR agonists through inhibition of p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics. J. Immunol. 2008 180(6):3797-806.

  11. Colonna-Romano G, Akbar AN, Aquino A, Bulati M, Candore G, Lio D, Ammatuna P, Fletcher JM, Caruso C, Pawelec G. Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily. Exp Gerontol. 2007 42(10):995-1002.

  12. Plunkett FJ, Franzese O, Finney HM, Fletcher JM, Belaramani LL, Salmon M, Dokal I, Webster D, Lawson AD, Akbar AN. The loss of telomerase activity in highly differentiated CD8+CD28-CD27- T cells is associated with decreased Akt (Ser473) phosphorylation. J Immunol. 2007 178(12):7710-9.

  13. Vukmanovic-Stejic M, Zhang Y, Cook JE, Fletcher JM, McQuaid A, Masters JE, Rustin MH, Taams LS, Beverley PC, Macallan DC, Akbar AN. Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo. J Clin Invest. 2006 116(9):2423-33.

  14. Fletcher JM, Vukmanovic-Stejic M, Dunne PJ, Birch KE, Cook JE, Jackson SE, Salmon M, Rustin MH, Akbar AN. Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion. J Immunol. 2005 175(12):8218-25.

  15. Plunkett FJ, Franzese O, Belaramani LL, Fletcher JM, Gilmour KC, Sharifi R, Khan N, Hislop AD, Cara A, Salmon M, Gaspar HB, Rustin MH, Webster D, Akbar AN. The impact of telomere erosion on memory CD8+ T cells in patients with X-linked lymphoproliferative syndrome. Mech Ageing Dev. 2005 126(8):855-65.

  16. Dunne PJ, Belaramani L, Fletcher JM, Fernandez de Mattos S, Lawrenz M, Soares MV, Rustin MH, Lam EW, Salmon M, Akbar AN. Quiescence and functional reprogramming of Epstein-Barr virus (EBV)-specific CD8+ T cells during persistent infection. Blood. 2005 106(2):558-65.

  17. Reed JR, Vukmanovic-Stejic M, Fletcher JM, Soares MV, Cook JE, Orteu CH, Jackson SE, Birch KE, Foster GR, Salmon M, Beverley PC, Rustin MH, Akbar AN. Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo. J Exp Med. 2004 199(10):1433-43.

  18. Soares MV, Plunkett FJ, Verbeke CS, Cook JE, Faint JM, Belaramani LL, Fletcher JM, Hammerschmitt N, Rustin M, Bergler W, Beverley PC, Salmon M, Akbar AN. Integration of apoptosis and telomere erosion in virus-specific CD8+ T cells from blood and tonsils during primary infection. Blood. 2004 103(1):162-7.

  19. Lantto J, Fletcher JM, Ohlin M. Binding characteristics determine the neutralizing potential of antibody fragments specific for antigenic domain 2 on glycoprotein B of human cytomegalovirus. Virology. 2003 305(1):201-9.

  20. *Lantto J, *Fletcher JM, Ohlin M. A divalent antibody format is required for neutralization of human cytomegalovirus via antigenic domain 2 on glycoprotein B. J Gen Virol. 2002 83(Pt 8):2001-5.
    (* equal contribution)

  21. Dunne PJ, Faint JM, Gudgeon NH, Fletcher JM, Plunkett FJ, Soares MV, Hislop AD, Annels NE, Rickinson AB, Salmon M, Akbar AN. Epstein-Barr virus-specific CD8+ T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potential. Blood. 2002 1;100(3):933-40.

  22. Taams LS, Vukmanovic-Stejic M, Smith J, Dunne PJ, Fletcher JM, Plunkett FJ, Ebeling SB, Lombardi G, Rustin MH, Bijlsma JW, Lafeber FP, Salmon M, Akbar AN. Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells. Eur J Immunol. 2002 32(6):1621-30.

  23. Fletcher JM, Prentice HG, Grundy JE. Natural killer cell lysis of cytomegalovirus (CMV)-infected cells correlates with virally induced changes in cell surface lymphocyte function-associated antigen-3 (LFA-3) expression and not with the CMV-induced down-regulation of cell surface class I HLA. J Immunol. 1998 161(5):2365-74.

  24. Grundy JE, Lawson KM, MacCormac LP, Fletcher JM, Yong KL. Cytomegalovirus-infected endothelial cells recruit neutrophils by the secretion of C-X-C chemokines and transmit virus by direct neutrophil-endothelial cell contact and during neutrophil transendothelial migration. J Infect Dis. 1998 177(6):1465-74.

    REVIEWS:
  25. Akbar AN, Fletcher JM. Memory T cell homeostasis and senescence during aging. Curr Opin Immunol. 2005 17(5):480-5. (Review)

  26. Dunne PJ and Fletcher JM. Recent advances in regulatory T cell therapy of autoimmunity, graft rejection and cancer. Recent Pat Inflamm Allergy Drug Discov. 2010 (3):231-43.

  27. Fletcher JM, Lalor SJ, Sweeney C, Tubridy N and Mills KHG. T cells in MS and EAE.  Clin Exp Immunol. 2010 162(1):1-11.

  28. Fletcher JM, Basdeo SA, Allen CA and Dunne PJ. Therapeutic use of vitamin D and its analogues in autoimmunity. Recent Pat Inflamm Allergy Drug Discov.2012 6(1):22-34.

  29. van Baarle D, Nanlohy NM, Otto S, Plunkett FJ, Fletcher JM, Akbar AN. Progressive Telomere Shortening of Epstein-Barr Virus-Specific Memory T Cells during HIV Infection: Contributor to Exhaustion? J Infect Dis. 2008 198(9):1353-7.

    BOOK CHAPTERS:
  30. Fletcher JM and Mills KHG. Immunology of multiple sclerosis. (in The Biology of Multiple Sclerosis). Cambridge University Press 2012. (Book Chapter)

  31. Dunne PJ, Rowan A, Fletcher JM and KHG Mills. IL-10 and TGF-beta-producing regulatory T cells in infection. (In Regulatory cells and Clinical Application). Springer 2008. (Book Chapter)