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School of Biochemistry and Immunology

You are here Research > Groups > Immunometabolism > Publications

Selected Publications

Peer reviewed Publications

  1. David J, O'Toole E, O'Reilly K, Thuery G, Assmann N, Finlay D, Harkin A. Inhibitors of the NMDA-Nitric Oxide Signaling Pathway Protect Against Neuronal Atrophy and Synapse Loss Provoked by l-alpha Aminoadipic Acid-treated Astrocytes. Neuroscience. 2018 Sep 27;392:38-56 doi: 10.1016/j.neuroscience.2018.09.023
  2. Michelet X, Dyck L, Hogan A, Loftus LM, Duquette D, Wei K, Beyaz S,Tavakkoli A, Foley C, Donnelly R, O'Farrelly C, Raverdeau M, Vernon A, Pettee W, O’Shea D,  Nikolajczyk BS,  Mills KH,  Brenner MB, Finlay DK and Lynch L.  Metabolic reprogramming of natural killer cells in obesity prevents cytotoxicity and promotes tumor progression. Nat. Immunol.2018 Dec;19(12):1330-1340. doi: 10.1038/s41590-018-0251-7.
  3. Loftus RM, Assmann N, Kedia-Mehta N, O'Brien KL, Garcia A, Gillespie C, Hukelmann JL, Oefner PJ, Lamond AI, Gardiner CM, Dettmer K, Cantrell DA, Sinclair LV, Finlay DK. Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice.  Nat Commun. 2018 Jun 14;9(1):2341. doi: 10.1038/s41467-018-04719-2
  4. Zaiatz-Bittencourt, D.K. Finlay*, C.M. Gardiner*. Canonical TGF  signalling pathway represses human NK cell metabolism.  J Immunol. 2018 Jun 15;200(12):3934-3941. doi: 10.4049/jimmunol.1701461 (*joint senior authors)
  5. Shehata HM, Murphy AJ, Lee MKS, Gardiner CM, Crowe SM, Sanjabi S, Finlay DK, Palmer CS. Sugar or Fat?-Metabolic Requirements for Immunity to Viral Infections.  Front Immunol. 2017 Oct 16;8:1311. doi: 10.3389/fimmu.2017.01311. eCollection 2017. Review
  6. Tobin LM, Mavinkurve M, Carolan E, Kinlen D, O'Brien EC, Little MA, Finlay DK, Cody D, Hogan AE, O'Shea D. NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient. JCI Insight. 2017 Dec 21;2(24). pii: 94939. doi: 10.1172/jci.insight.94939
  7. Assmann, A., O'Brien, K, Donnelly, R, Loftus, R, Heinrich, P., Oefner, P.J., Gardiner, C.M., Dettmer, K., Finlay, D.K. Sterol regulatory element binding proteins (Srebp) are essential for metabolic and functional responses in activated Natural Killer cells. Nat. Immunol. 2017 Nov;18(11):1197-1206. doi: 10.1038/ni.3838
  8. Gardiner CM, Finlay DK. What Fuels Natural Killers? Metabolism and NK Cell Responses. Front Immunol. 2017 Apr 3;8:367. doi: 10.3389/fimmu.2017.00367. eCollection 2017. Review
  9. Lawless SJ, Kedia-Mehta N, Walls JF, McGarrigle R, Convery O, Sinclair LV, Navarro MN, Murray J, Finlay DK.  Glucose represses dendritic cell-induced T cell responses. Nat Commun. 2017 May 30;8:15620. doi: 10.1038/ncomms15620
  10. Walls, J., Sinclair, L. V., Finlay. D. K. (2016) Nutrient Sensing, Signal Transduction and Immune Responses. Semin Immunol. Oct;28(5):396-407. doi: 10.1016/j.smim.2016.09.001
  11. Assmann, N., Finlay, D. K. (2016). Metabolic regulation of immune responses; therapeutic opportunities. J Clin Invest  Jun 1;126(6):2031-9. doi: 10.1172/JCI8300
  12. Keating, SE., Zaiatz-Bittencourt, V., Loftus, RM., Keane, C., Finlay, DK*., Gardiner, CM*. (*joint senior authors) (2016). Metabolic reprogramming supports IFNγ production by CD56bright NK cells. Journal of Immunology Mar 15;196(6):2552-60. doi: 10.4049/jimmunol.1501783
  13. Viel, S., Marçais, A., Guimaraes, F., Loftus, R., Rabilloud, J., Grau, M., Degouve, S., Djebali, S., Sanlaville, a., Charrier, E., Bienvenu, J., Marie, JC., Caux, C.,  Marvel, J., Town, L., Huntington, N., Bartholin, L., Finlay, DK., Smyth, MJ., Walzer, T. (2015) TGF-β inhibits NK cell activation and functions through repression of the mTOR pathway. Science Signalling. Feb 16;9(415):ra19. doi: 10.1126/scisignal.aad1884
  14. Loftus, R. M., & Finlay, D. K. (2016). Immunometabolism; cellular metabolism turns immune regulator. J Biol Chem.  Mar 15;196(6):2552-60. doi: 10.4049/jimmunol.1501783
  15. Donnelly, R. P., & Finlay, D. K. (2015). Glucose, glycolysis and lymphocyte responses. Mol Immunol. http://doi.org/10.1016/j.molimm.2015.07.034
  16. Donnelly, RP, Loftus RM, Keating SE, Liou KT, Biron CA, Gardiner CM, Finlay DK, (2014) mTORC1-dependent metabolic reprogramming is a prerequisite for Natural Killer cell effector function. Journal of Immunology  Nov 1;193(9):4477-84. doi: 10.4049/jimmunol.1401558
  17. Zarrouk, M., Finlay, DK., Foretz, M., Viollet, B., & Cantrell, D. A. (2014). Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells. PLoS ONE, 9(9), e106710. doi:10.1371/journal.pone.0106710
  18. Finlay, D. K. (2013). mTORC1 regulates CD8 +T-cell glucose metabolism and function independently of PI3K and PKB. Biochem Soc Trans, 41(2), 681–686.
  19. Rolf J, Zarrouk M, Finlay DK, Foretz M, Viollet B, Cantrell DA. AMPKa1: A glucose sensor that controls CD8 T‐cell memory. Eur J Immunol. 2013 Jan 11
  20. Finlay DK, Rosenzweig R, Sinclair LV, Feijoo Carnero C, Panteleyev AA, Okkenhaug K, Cantrell DA. PDK1/mTOR and Hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells. J Exp Med 2012 Dec 17;209(13):2441-53  (Joint Corresponding Author)
  21. Finlay DK. Regulation of glucose metabolism in T cells: new insight into the role of Phosphoinositide 3-kinases. Frontiers in Immunology 2012; 3:247. (Invited review article)
  22. Finlay DK, Cantrell DA. Metabolism, migration and memory in cytotoxic T cells. Nat Rev Immunol. 2011 Feb;11(2):109-17. (Invited review article)
  23. Macintyre A, Finlay DK, Preston G, Sinclair LV, Waugh CM, Tamas P, Feijoo C, Okkenhaug K, Cantrell DA. Protein Kinase B/Akt controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.   Immunity 2011 Feb 25;34(2):224-36.
  24. Finlay DK, Cantrell DA. The co-ordination of T cell function by Serine/threonine kinases. Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1). (Invited review article)
  25. Finlay DK, Kelly AP, Clarke R, Sinclair LV, Deak M, Alessi DR, Cantrell DA. Temporal differences in the dependency on Phosphoinositide dependent kinase 1 distinguish the development of Va14 iNKT cells, regulatory T cells and conventional T cells.  J Immunol. 2010 180(10); 5793.
  26. Finlay DK, Cantrell DA.  Phosphoinositide 3-kinase and mammalian target of rapamycin pathways control T-cell migration.  Ann N Y Acad Sci. 2010 Jan;1183:149-57. (Invited review article) 
  27. Tamás P,  Macintyre A, Finlay DK, Clarke R, Feijoo‐Carnero C, Ashworth A, Cantrell DA. LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells. Eur J Immunol 2010 40(1): 242-253.
  28. Finlay DK, Sinclair LV, Fejoo C, Waugh C, Hagenbeek TJ, Spits H, Cantrell DA. Phosphoinositide dependent kinase 1 determines migratory capacity not cell growth and proliferation in PTEN-null lymphocytes.  Journal of Experimental Medicine. 2009 Oct 26;206(11):2441-54
  29. Waugh C, Sinclair LV, Finlay DK, Bayascas JR, Cantrell DA. Phosphoinositide (3,4,5)-Triphosphate Binding to Phosphoinositide-Dependent Kinase 1 Regulates a Protein Kinase B/Akt Signaling Threshold That Dictates T-Cell Migration, Not Proliferation. Mol. Cell. Biol. 2009  Nov 29(21): 5952-5962. 
  30. Sauer S, Bruno L, Hertweck A, Finlay D, Leleu M, Spivakov M, Knight ZA, Cobb BS, Cantrell D, O'Connor E, Shokat KM, Fisher AG, Merkenschlager M. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7797-802.
  31. Sinclair LV, Finlay D, Fejoo C, Cornish GH, Gray A, Ager A, Okkenhaug K, Hagenbeek TJ, Spits H., Cantrell DA.   Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking.  Nat Immunol. 2008 May;9(5):513-21.
  32. Kelly AP, Finlay DK, Hinton HJ, Clarke RG, Fiorini E, Radtke F, Cantrell DA.  Notch-induced T cell development requires phosphoinositide-dependent kinase 1.  EMBO J. 2007 Jul 25;26(14):3441-50.
  33. Finlay D, Ruiz-Alcaraz AJ, Lipina C, Perrier S, Sutherland C. A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression. J Mol Endocrinol. 2006 Oct;37(2):227-37
  34. Liu HK, Perrier S, Lipina C, Finlay D, McLauchlan H, Hastie CJ, Hundal HS, Sutherland C. Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226. BMC Mol Biol 2006, 7:14.
  35. Lipina C, Huang X, Finlay DK, McManus EJ, Alessi DR, Sutherland C. Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3. Biochem J. 2005 Dec 15;392(Pt 3): 633–639.
  36. Finlay D, Patel S, Dickson L.M, Shapiro N, Marquez R, Rhodes C.J, Sutherland C.  Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.  BMC Mol Biol. 2004 Sep 06;5(1):15.

Non-peer reviewed publications

  1. Finlay, D. K. (2015). Starved human T lymphocytes keep fighting. Eur J Immunol 45(9), 2480–2483. doi.org/10.1002/eji.201545885. (Invited commentary article)
  2. Finlay, D. K. (2015). Metabolic regulation of natural killer cells., 43(4), Biochem Soc Trans 758–762. http://doi.org/10.1042/BST20150116
  3. Finlay, D.K. IRF4 links antigen affinity to CD8+ T-cell metabolism. Immunol. Cell. Biol 2013 Oct 29. doi: 10.1038/icb.2013.72 (Invited commentary article)