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School of Biochemistry and Immunology

You are here Research > Groups > Cell Signalling in Cancer and Inflammation > Publications

Selected Publications

  1. Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis. Flood B, Manils J, Nulty C, Flis E, Kenealy S, Barber G, Fay J, Mills KHG, Kay EW, Creagh EM. Oncogene. 2018 Dec 11. doi: 10.1038/s41388-018-0613-5. [Epub ahead of print]

  2. Emerging methods in colorectal cancer screening. Ryan EJ, Creagh EM. Br J Surg. 2018 Jan;105(2):e16-e18. doi: 10.1002/bjs.10650.

  3. Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation. Basdeo SA, Campbell NK, Sullivan LM, Flood B, Creagh EM, Mantle TJ, Fletcher JM, Dunne A. Transl Res. 2016 Dec;178:81-94.e2. doi: 10.1016/j.trsl.2016.07.011.

  4. Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential. Flood B, Oficjalska K, Laukens D, Fay J, O'Grady A, Caiazza F, Heetun Z, Mills KH, Sheahan K, Ryan EJ, Doherty GA, Kay E, Creagh EM. Clin Exp Immunol. 2015 Jul;181(1):39-50. doi: 10.1111/cei.12617.

  5. Protective role for caspase-11 during acute experimental murine colitis. Oficjalska K, Raverdeau M, Aviello G, Wade SC, Hickey A, Sheehan KM, Corr SC, Kay EW, O'Neill LA, Mills KH, Creagh EM. J Immunol. 2015 Feb 1;194(3):1252-60. doi: 10.4049/jimmunol.1400501.

  6. Caspase crosstalk: integration of apoptotic and innate immune signalling pathways. Creagh EM. Trends Immunol. 2014 Dec;35(12):631-640. doi: 10.1016/j.it.2014.10.004.

  7. Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. Harris J, Hartman M, Roche C, Zeng SG, O'Shea A, Sharp FA, Lambe EM, Creagh EM, Golenbock DT, Tschopp J, Kornfeld H, Fitzgerald KA, Lavelle EC. J Biol Chem. 2011 Mar 18;286(11):9587-97. doi: 10.1074/jbc.M110.202911.

  8. The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis. Lavelle EC, Murphy C, O'Neill LA, Creagh EM. Mucosal Immunol. 2010 Jan;3(1):17-28. doi: 10.1038/mi.2009.124.

  9. Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion. Becker CE, Creagh EM, O'Neill LA. J Biol Chem. 2009 Dec 11;284(50):34531-7. doi: 10.1074/jbc.M109.046102.

  10. Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival. Creagh EM, Brumatti G, Sheridan C, Duriez PJ, Taylor RC, Cullen SP, Adrain C, Martin SJ. PLoS One. 2009;4(3):e5055. doi: 10.1371/journal.pone.0005055

  11. TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Creagh EM, O'Neill LA. Trends Immunol. 2006 Aug;27(8):352-7.

  12. Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man. Adrain C, Creagh EM, Cullen SP, Martin SJ. J Biol Chem. 2004 Aug 27;279(35):36923-30.

  13. Interchain proteolysis, in the absence of a dimerization stimulus, can initiate apoptosis-associated caspase-8 activation. Murphy BM, Creagh EM, Martin SJ. J Biol Chem. 2004 Aug 27;279(35):36916-22.

  14. Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes. Hill MM, Adrain C, Duriez PJ, Creagh EM, Martin SJ. EMBO J. 2004 May 19;23(10):2134-45.

  15. Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins. Creagh EM, Murphy BM, Duriez PJ, Duckett CS, Martin SJ. J Biol Chem. 2004 Jun 25;279(26):26906-14.

  16. Caspase-activation pathways in apoptosis and immunity. Creagh EM, Conroy H, Martin SJ. Immunol Rev. 2003 Jun;193:10-21.

  17. Cell stress-associated caspase activation: intrinsically complex? Creagh EM, Martin SJ. Sci STKE. 2003 Mar 25;2003(175):pe11. Review.

  18. Defying death: showing Bcl-2 the way home. Adrain C, Creagh EM, Martin SJ. Nat Cell Biol. 2003 Jan;5(1):9-11.

  19. Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. Adrain C, Creagh EM, Martin SJ. EMBO J. 2001 Dec 3;20(23):6627-36.

  20. Caspases: cellular demolition experts. Creagh EM, Martin SJ. Biochem Soc Trans. 2001 Nov;29(Pt 6):696-702. Review.

  21. CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways. Bouchier-Hayes L, Conroy H, Egan H, Adrain C, Creagh EM, MacFarlane M, Martin SJ. J Biol Chem. 2001 Nov 23;276(47):44069-77.

  22. Heat shock proteins--modulators of apoptosis in tumour cells. Creagh EM, Sheehan D, Cotter TG. Leukemia. 2000 Jul;14(7):1161-73.

  23. Heat shock protein 70 inhibits caspase-dependent and -independent apoptosis in Jurkat T cells. Creagh EM, Carmody RJ, Cotter TG. Exp Cell Res. 2000 May 25;257(1):58-66.

  24. The antioxidant 4b,5,9b,10-Tetrahydroindeno[1,2-b]indole inhibits apoptosis by preventing caspase activation following mitochondrial depolarization. Devitt GP, Creagh EM, Cotter TG. Biochem Biophys Res Commun. 1999 Nov 2;264(3):622-9.

  25. Selective protection by hsp 70 against cytotoxic drug-, but not Fas-induced T-cell apoptosis. Creagh EM, Cotter TG. Immunology. 1999 May;97(1):36-44.