Selected Publications
Guy, C., Baran, M., Ribó-Molina, P., van den Hoogen, B.G. and Bowie, A.G. (2023). Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores. iScience 26, 107698, September 15, 2023
Baran, M., Feriotti, C., McGinley, A., Carlile, S.R., Jiang, Z., Calderon-Gonzalez, R., Dumigan, A., Sa-Pessoa, J., Sutton, C.E., Kearney, J., McLoughlin, R.M., Mills, K.H.G., Fitzgerald, K.A., Bengeochea, J.A. and Bowie, A.G. (2023) PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of Klebsiella pneumoniae infection. Cell Reports 42: 112341. Doi: 10.1016/j.celrep.2023.112341
Feriotti C, Sá-Pessoa J, Calderón-González R, Gu L, Morris B, Sugisawa R, Insua JL, Carty M, Dumigan A, Ingram RJ, Kissenpfening A, Bowie AG, Bengoechea JA (2022) Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity. Cell Reports 40: 111167. doi: 10.1016/j.celrep.2022.111167
Guy, C. & Bowie, A.G. (2022) Recent insights into innate immune nucleic acid sensing during viral infection Current Opinion in Immunology 78: 102250
*Gu, L., *Casserly, D., Brady, G., Carpenter, S., Bracken, A.O., Fitzgerald, K.A., Unterholzner, L. and Bowie, A.G. (2022) MNDA controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7 Nature Communications (2022) 13:14. https://doi.org/10.1038/s41467-021-27701. *equal contribution
Carty, M., Guy, C. and Bowie, A.G. (2021) Detection of viral infections by innate immunity. Biochem Pharmacol 183: 114316; doi: 10.1016/j.bcp.2020.114316.
*Doran, C.G., *Sugisawa, R., Carty, M., Roche, F., Fergus, C., Hokamp, K., Kelly, V.P. and Bowie, A.G. (2021) CRISPR/Cas9-mediated SARM1 knockout and epitope-tagged mice reveal that SARM1 does not regulate nuclear transcription, but is expressed in macrophages. J. Biol. Chem. 297: 101417. *equal contribution
Massa, D., Baran, M., Bengoechea, J.A. & Bowie, A.G. (2020) PYHIN1 regulates pro-inflammatory cytokine induction rather than innate immune DNA sensing in airway epithelial cells. J Biol Chem 295: 4438-4450.
Musilova, J., Mulcahy, M.E., Kuijk, M.M., McLoughlin, R.M. and Bowie, A.G. (2019) Toll-like receptor 2–dependent endosomal signaling by Staphylococcus aureus in monocytes induces type I interferon and promotes intracellular survival. J Biol Chem 294: 17031-17042.
Carty, M., Kearney, J., Shanahan, K.A., Hams, E., Sugisawa, R., Connolly, D., Doran, C.G., Muñoz-Wolf, N., Gürtler, C., Fitzgerald, K.A., Lavelle, E.C., Fallon, P.G. and Bowie, A.G. (2019) Cell survival and cytokine release after inflammasome activation is regulated by the Toll-IL-1R protein SARM. Immunity Published May 07, 2019. DOI: https://doi.org/10.1016/j.immuni.2019.04.005
Bowie, A.G. (2019) Harnessing poxviral know-how for anti-cytokine therapies. J Biol Chem 294: 5228-5229.
Carty, M. and Bowie, A.G. (2019) SARM: From immune regulator to cell executioner. Biochem Pharmacol. 161: 52-62. doi.org/10.1016/j.bcp.2019.01.005
Dempsey, A., Keating, S.E., Carty, M. & Bowie, A.G. (2018) Poxviral protein E3–altered cytokine production reveals that DExD/H-box helicase 9 controls Toll-like receptor–stimulated immune responses. J Biol Chem 293: 14989-15001.
Dunphy G, Flannery SM, Almine JF, Connolly DJ, Paulus C, Jønsson KL, Jakobsen MR, Nevels MM, Bowie AG, Unterholzner L. (2018) Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage. Molecular Cell 71(5):745-760.e5.
Bowie AG (2018) Self-RNA sentinels signal viral invasion. Nature Immunology 19(1):4-5.
Sisquella X, Ofir-Birin Y, Pimentel MA, Cheng L, Abou Karam P, Sampaio NG, Penington JS, Connolly D, Giladi T, Scicluna BJ, Sharples RA, Waltmann A, Avni D, Schwartz E, Schofield L, Porat Z, Hansen DS, Papenfuss AT, Eriksson EM, Gerlic M, Hill AF, Bowie AG, Regev-Rudzki N. (2017) Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors. Nature Communications 8(1):1985.
Brady, G., Haas, D.A., Farrell, P.F., Pichlmair, A. and Bowie, A.G. (2017) Molluscum Contagiosum Virus protein MC005 inhibits NFκB activation by targeting NEMO-regulated IKK activation. J. Virol. 91: e00545-17.
Almine, J.F., O'Hare, C.A.J., Dunphy G., Haga, I.R., Naik, R.J., Atrih, A., Connolly, D.J., Taylor, J., Kelsall, I.R., Bowie, A.G., Beard, P.M. and Unterholzner, L. (2017) IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes Nature Communications 8: 14392.
Carroll, L., Jin, L., Mori, A., Munoz-Wolf, N., Oleszycka, E., Moran, H., Mansouri, S., McEntee, C., Lambe, E., Agger, E.M., Andersen, P., Cunningham, C., Hertzog, P., Fitzgerald, K.A., Bowie, A.G. and Lavelle, E.C. (2016) The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons Immunity 44, 597-608.
Shirey, K.A, Lai, W., Pletneva, L.M., Patel, M., Pang, C., Kurt-Jones, E., Lipsky, M., Roger, T., Calandra, T., Tracey, K., Al Abed, Y., Bowie, A.G., Fasano, A., Dinarello, C., Gusovsky, F., Blanco, J.C.G., and Vogel S.N. (2016) Novel Strategies for Targeting Innate Immune Responses to Influenza Mucosal Immunology 9, 1173-82.
Brady, G., Haas, D.A., Farrell, P.J., Pichlmair, A and Bowie, A.G. (2015) Poxvirus protein MC132 from Molluscum Contagiosum Virus inhibits NFkappaB activation by targeting p65 for degradation. J. Virol. 89, 8406-8415.
Dempsey, A. and Bowie, A.G. (2015) Innate Immune Recognition of DNA: a recent history. Virology 479-480: 146-152
Stack, J, Doyle, S.L., Connolly, D.J., Reinert, L.S., O’Keeffe, K.M., McLoughlin, R.M., Paludan, S.R. and Bowie, A.G. (2014) TRAM is required for TLR2 endosomal signaling to type I IFN induction. J. Immunol. 193, 6090-6102.
Brady, G & Bowie, A.G. 2014. Innate Immune activation of NFkappaB and its antagonism by poxviruses. Cytokine and Growth Factor Reviews 25, 611-620.
Verstak, B., Stack, J., Ve, T., Mangan, M., Hjerrild, K., Jeon, J., Stahl, R., Latz, E., Gay, N., Kobe, B., Bowie, A.G., and Mansell, A. (2014) The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4. J. Leuk Biol. 96, 427 – 436.
Connolly, D & Bowie A.G. 2014. The emerging role of human PYHIN proteins in innate immunity: implications for health and disease. Biochem Pharmacol. 92, 405-414.
Bowie, A.G. 2014. Rad50 and CARD9, missing links in cytosolic DNA-stimulated inflammation. Nat. Immunol. 15, 534-536.
Gürtler, C., Carty, M., Kearney, J., Schattgen, S.A., Ding, A., Fitzgerald, K.A. and Bowie, A.G. 2014. SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter. J. Immunol. 192, 4821-4832.
Carty, M., Reinert, L., Paludan, S.R. & Bowie, A.G. 2014. Innate antiviral signalling in the central nervous system. Trends Immunol. 35, 79-87.
Stack, J., Hurst, T.P., Flannery, S.M., Brennan, K., Rupp, S., Oda, S-I., Khan, A.R. and Bowie, A.G. 2013. Poxviral Protein A52 Stimulates p38 MAPK Activation by Causing TRAF6 Self-Association leading to TAK1 recruitment. J. Biol. Chem. 288, 33642-33653.
Bowie, A.G. 2013. Removing the TREX1 Safety Net: Oxidized DNA Overcomes Immune Silencing by Exonuclease TREX1. Immunity 39: 423-425.
Gürtler, C & Bowie, A.G. 2013. Innate Immune Detection of Microbial Nucleic Acids. Trends Microbiol. 21: 413-420.
Paludan, S.R. & Bowie, A.G. 2013. Immune Sensing of DNA. Immunity 38, 870-880.
O’Neill, L.A.J., Golenbock, D. & Bowie, A.G. 2013. The history of Toll-like receptors – redefining innate immunity. Nat. Reviews Immunol. 13, 453-460. (33.3) §2
Mansur, D.S., Maluquer de Motes, C., Unterholzner, L., Sumner, R.P., Ferguson, B.J., Ren, H., Strnadova, P., Bowie, A.G. & Smith, G.L. 2013. Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: A mechanism to inhibit NF-kappaB activation and promote immune evasion and virulence. PLoS Pathogens 9, e1003183.
Bowie, A.G. 2012. Innate sensing of bacterial cyclic dinucleotides: more than just STING. Nat. Immunol. 13, 1137-1139.
Pichlmair, A., Kandasamy, K., Alvisi, G., Mulhern, O., Sacco, R., Habjan, M., Binder, M., Stefanovic, A., Eberle, C., Goncalves, A., Bürckstümmer, T., Müller, A., Fauster, A., Holze, C., Lindsten, K., Goodbourn, S., Kochs, G., Weber, F., Bartenschlager, R., Bowie, A.G., Bennett, K.L., Colinge, J. & Superti-Furga, G. 2012. Viral immune modulators perturb the human molecular network by common and unique strategies. Nature 487, 486-490.
Stack, J., Bowie, A.G. 2012. Poxviral protein A46 antagonises toll-like receptor 4 signaling by targeting BB loop motifs in toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions. J. Biol. Chem. 287, 22672-22682.
Jin, T., Perry, A., Jiang, J., Smith, P., Curry, J., Unterholzner, L., Jiang, Z., Horvath, G., Rathinam, V., Hornung, V., Latz, E., Bowie, A.G., Fitzgerald, K.A., Xiao, T. Structures of The HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of The AIM2 Inflammasome and IFI16 Receptor. 2012. Immunity 36, 561-571.
Bowie, A.G. 2012. The STING in the Tail for Cytosolic DNA-Dependent Activation of IRF3. Sci. Signal. 5, pe9
Unterholzner, L., Sumner, R.P., Baran, M., Ren, H., Mansur, D.S., Bourke, N.M., Randow, F., Smith, G.L., & Bowie, A.G. 2011. Vaccinia Virus Protein C6 is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7. 2011. PLoS Pathogens 7, e1002247
O’Neill, L.A.J. & Bowie, A.G. 2011. The Powerstroke and Camshaft of the RIG-I Antiviral RNA Detection Machine. Cell 147, 259-261.
Keating, S.E., Baran, M & Bowie, A.G. 2011. Cytosolic DNA sensors regulating type I interferon induction. Trends Immunol. 32, 574-581.
Paludan, S.R., Levy, O. & Bowie, A.G. 2011. Toll2011 at Lago di Garda: studying danger sensors by the guard towers at the lake. Nat. Immunol. 12, 805-808.
Sinead M. Flannery, S.M., Keating, S.E., Szymak, J., & Bowie, A.G. 2011. Human Interleukin-1 Receptor-associated Kinase-2 Is Essential for Toll-like Receptor-mediated Transcriptional and Post-transcriptional Regulation of Tumor Necrosis Factor alpha. J. Biol. Chem. 286, 23688-23697.
Unterholzner, L. & Bowie, A.G. 2011. Innate DNA Sensing Moves to the Nucleus. Cell Host Microbe 9, 351-353.
Carty, M. & Bowie, A.G. 2011. Evaluating the role of Toll-like receptors in diseases of the central nervous system. Biochem Pharmacol. 81, 825-837.
Paludan, S.R., Bowie, A.G., Horan, K.A., & Fitzgerald, K.A. 2011. Recognition of herpesviruses by the innate immune system. Nat. Reviews Immunol. 11, 143-154.
Unterholzner, L., Keating, S.E., Baran, M., Horan, K.A., Jensen, S.B., Sharma, S., Sirois, C.M. , Jin, T., Latz, E., Xiao, T.S., Fitzgerald, K.A., Paludan, S.R. & Bowie, A.G. 2010. IFI16 is an innate immune sensor for intracellular DNA. Nat. Immunol. 11, 997-1005.
Lysakova-Devine, T., Keogh, B., Harrington, B., Nagpal, K., Halle, A., Golenbock, D.T., Monie, T. & Bowie, A.G. 2010. Viral Inhibitory Peptide of TLR4, a Peptide Derived from Vaccinia Protein A46, Specifically Inhibits TLR4 by Directly Targeting MyD88 Adaptor-Like and TRIF-Related Adaptor Molecule. J. Immunol. 185, 4261-4271.
Flannery, S. & Bowie, A.G. 2010. The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling. Biochem. Pharmacol. 80: 1981-1991.
Bowie, A.G. 2010. TRAF3: uncovering the real but restricted role in human. Immunity 33, 293-295.
Brennan, K. & Bowie, A.G. 2010. Activation of host pattern recognition receptors by viruses. Curr. Opin. Microbiol. 13: 503-507.
Mulhern, O. & Bowie, A.G. 2010. Unexpected roles for DEAD-box protein 3 in viral RNA sensing pathways. Eur. J. Immunol. 40, 933-935.
O'Neill, L.A.J. & Bowie, A.G. 2010. Sensing and Signaling in Antiviral Innate Immunity. Curr. Biol. 20, R328-R333.
Keating, S.E. & Bowie, A.G. 2009. The role of non-degradative ubiquitination in interleukin-1 and Toll-like receptor signalling. J. Biol. Chem. 284, 8211-8215.
Bowie, A.G. and Unterholzner, L. 2008. Viral evasion and subversion of pattern-recognition receptor signalling. Nat. Reviews Immunol. 8, 911-922.
Schröder, M., Baran, M. & Bowie, A.G. 2008. Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKe-mediated IRF activation. EMBO J. 27, 2147–2157.
Bowie, A.G. 2008. TRIM-ing down Tolls. Nat. Immunol. 9, 348-350.
Unterholzner, L. & Bowie, A.G. 2008. The interplay between viruses and innate immune signalling: recent insights and therapeutic opportunities. Biochem. Pharmacol. 75, 589-602.
Keating, S.E., Maloney, G.M., Moran, E.M. & Bowie, A.G. 2007. IRAK-2 participates in multiple toll-like receptor signalling pathways to NFkappaB via activation of TRAF6 ubiquitination. J. Biol. Chem. 282, 33435-33443.
O'Neill, L.A.J & Bowie, A.G. 2007. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat. Reviews Immunol. 7, 353-364.
Bowie, A.G. & Fitzgerald, K.F. 2007. RIG-I; Tri-ing to discriminate between self and non-self RNA. Trends Immunol. 28, 147-150.
Carty, M., Goodbody, R., Schröder, M., Stack, J., Moynagh, P.N. & Bowie, A.G. 2006. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signalling. Nat. Immunol. 7, 1074-1081.
Stack, J. Haga, I.R., Schröder, M., Bartlett , N.W., Maloney, G., Reading, P.C., Fitzgerald, K.A., Smith, G.L. & Bowie, A.G. 2005. Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence. J. Exp. Med. 201 , 1007-1018.
Maloney, G, Schröder, M & Bowie A.G. 2005. Vaccinia virus protein A52R activates p38 mitogen activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10. J. Biol. Chem. 280, 30838-30844.