Publications and Further Research Outputs
Peer-Reviewed Publications
Franklin, E., Mantle, T., Dunne, A., Activation of human biliverdin-IXα reductase by urea: Generation of kinetically distinct forms during the unfolding pathway, Biochimica et Biophysica Acta - Proteins and Proteomics, 1834, (12), 2013, p2573-2578
McManus, G., Costa, M., Canals A., Coll, M., & Mantle, T.J. , Site-directed mutagenesis of mouse glutathione transferase P1-1 unlocks masked co-operativity, introduces a novel mechansim for ping-pong kinetic behaviour and provides further structural evidence for participation of a water molecule in proton abstraction from glutathione, FEBS Journal, 278, 2011, p273 - 281
Hayes, J.M. and Mantle, T.J., The effect of pH on the initial rate kinetics of the dimeric biliverdin-IXα reductase from the cyanobacterium Synechocystis PCC6803 , FEBS Journal, 276, 2009, p4414-4425
Franklin, E., Browne, S., Horan, A.E., Inomata,K., Hammam, M.A.S., Kinoshita, H., Lamparter,T., Golfis, G. and Mantle, T.J. , The use of synthetic linear tetrapyrroles to probe the verdin sites of human biliverdin-IXα reductase and human biliverdin-IXβ reductase , FEBS Journal, 276, 2009, p4405-4413
L. J.Smith, S. Browne, A. J. Mulholland and T. J. Mantle, Computational and experimental studies on the catalytic mechanism of biliverdin IXβ reductase, Biochemical Journal, 411, 2008, p475-484
Edward Franklin, Seamus Browne, Jerrard Hayes, Coilin Boland, Aisling Dunne, Gordon Elliot, and Timothy J. Mantle, Activation of biliverdin-IXα reductase by inorganic phosphate and related anions, Biochemical Journal, 405, 2007, p61-67
Mantle TJ & Noone P., Chromatofocusing, Methods Mol Biol, 244, 2004, p233 - 237
Tetlow, N., Robinson , A., Mantle, T. & Board, P., Polymorphism of human Mu class glutathione transferases, Pharmacogenetics, 14 , 2004, p359 - 368
TJ Mantle (ed), The Behaviour of Enzymes in Cells, Biochem. Soc. Trans, 31, 2003, pp711 - 739
MANTLE, TJ, HAEM DEGRADATION IN ANIMALS AND PLANTS, BIOCHEMICAL SOCIETY TRANSACTIONS, 30, 2002, p630 - 633
PEREIRA, PJB, MACEDO-RIBEIRO, S, PARRAGA, A, PEREZ-LUQUE, R, CUNNINGHAM, O, DARCY, K, MANTLE, TJ, COLL, M, STRUCTURE OF HUMAN BILIVERDIN IX BETA REDUCTASE, AN EARLY FETAL BILIRUBIN IX BETA PRODUCING ENZYME, NATURE STRUCTURAL BIOLOGY, 8, 2001, p215 - 220
MANTLE, TJ, ENZYMES: NATURE'S NANOMACHINES, BIOCHEMICAL SOCIETY TRANSACTIONS, 29, 2001, p331 - 336
Spectrophotometric assays in, editor(s)M.G. Gore , Spectrophotomety and spectrofluorimetry, Oxford, Oxford University Press, 2000, pp183 - 208, [Mantle, T.J. & Harris]
CUNNINGHAM, O, DUNNE, A, SABIDO, P, LIGHTNER, D, MANTLE, TJ, STUDIES ON THE SPECIFICITY OF THE TETRAPYRROLE SUBSTRATE FOR HUMAN BILIVERDIN-IX ALPHA REDUCTASE AND BILIVERDIN-IX BETA REDUCTASE - STRUCTURE-ACTIVITY RELATIONSHIPS DEFINE MODELS FOR BOTH ACTIVE SITES, JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 2000, p19009 - 19017
CUNNINGHAM, O, GORE, MG, MANTLE, TJ, INITIAL-RATE KINETICS OF THE FLAVIN REDUCTASE REACTION CATALYSED BY HUMAN BILIVERDIN-IX BETA REDUCTASE (BVR-B), BIOCHEMICAL JOURNAL, 345, 2000, p393 - 399
Mantle, T.J., Parraga, A., Vega, M.C., Garcia-Saez, I., Walsh, S.B., Phillips, M. & Coll, M., Studies on the reaction mechanism of mouse liver glutathione S-transferase P1-1, Clin. Chem. & Enzym. Commun., 8, 1999, p223 - 230
WALSH, SB, FRANKLIN, E, MANTLE, TJ, EVIDENCE FOR MODULATION OF THE INTERACTION BETWEEN CYS-47 AND LYS-54 IN GLUTATHIONE S-TRANSFERASE PI BY THE NATURE OF THE RESIDUE AT POSITION 56, BIOCHEMICAL SOCIETY TRANSACTIONS, 25, 1998, pS614 - S614
Glutathione conjugation in, editor(s)N Gooderham , Drug Metabolism: Towards the Millenium, Amsterdam, IOS Press, 1998, pp101 - 108, [Mantle, T.J.]
PARRAGA, A, GARCIA-SAEZ, I, WALSH, SB, MANTLE, TJ, COLL, M, THE THREE-DIMENSIONAL STRUCTURE OF A CLASS-PI GLUTATHIONE S-TRANSFERASE COMPLEXED WITH GLUTATHIONE: THE ACTIVE-SITE HYDRATION PROVIDES INSIGHTS INTO THE REACTION MECHANISM, BIOCHEMICAL JOURNAL, 333, 1998, p811 - 816
VEGA, MC, WALSH, SB, MANTLE, TJ, COLL, M, THE THREE-DIMENSIONAL STRUCTURE OF CYS-47-MODIFIED MOUSE LIVER GLUTATHIONE S-TRANSFERASE P1-1 - CARBOXYMETHYLATION DRAMATICALLY DECREASES THE AFFINITY FOR GLUTATHIONE AND IS ASSOCIATED WITH A LOSS OF ELECTRON DENSITY IN THE ALPHA B-3(10)B REGION, JOURNAL OF BIOLOGICAL CHEMISTRY, 273, 1998, p2844 - 2850
CUNNINGHAM, O, MANTLE, TJ, CLONING, OVEREXPRESSION AND PURIFICATION OF BILIVERDIN IX-BETA REDUCTASE., BIOCHEMICAL SOCIETY TRANSACTIONS, 25, 1998, pS613 - S613
ENNIS, O, MAYTUM, R, MANTLE, TJ, CLONING AND OVEREXPRESSION OF RAT KIDNEY BILIVERDIN IX ALPHA REDUCTASE AS A FUSION PROTEIN WITH GLUTATHIONE S-TRANSFERASE: STEREOCHEMISTRY OF NADH OXIDATION AND EVIDENCE THAT THE PRESENCE OF THE GLUTATHIONE S-TRANSFERASE DOMAIN DOES NOT EFFECT BVR-A ACTIV, BIOCHEMICAL JOURNAL, 328, 1997, p33 - 36
MURPHY, KC, GRAHAM, M, MANTLE, T, SHELLEY, RK, SCHIZOPHRENIA, LUNG CANCER AND GLUTATHIONE-S-TRANSFERASE-MU, IRISH JOURNAL OF PSYCHOLOGICAL MEDICINE, 13, 1997, p138 - 139
OROZCO, M, VEGA, C, PARRAGA, A, GARCIASAEZ, I, COLL, M, WALSH, S, MANTLE, TJ, LUQUE, FJ, ON THE REACTION MECHANISM OF CLASS PI GLUTATHIONE S-TRANSFERASE, PROTEINS-STRUCTURE FUNCTION AND GENETICS, 28, 1997, p530 - 542
Cunningham, O. & Mantle, T.J., Cloning, overexpression and purification of biliverdin-IX reductase, Biochem. Soc. Trans., 25, 1997, pS613 - S613
Walsh, S.B., Franklin, E. & Mantle, T.J., Evidence for modulation of the interaction between cys-47 and lys-54 in glutathione S-transferase Pi by the nature of the residue at position-56, Biochem. Soc. Trans., 25, 1997, pS614 - S614
Chromatofocusing in, editor(s)S. Doonan , Protein Purification Protocols, Totowa, New Jersey, Humana Press, 1996, pp249 - 254, [Mantle, T.J. & Noone, P.]
SHALLOE, F, ELLIOTT, G, ENNIS, O, MANTLE, TJ, EVIDENCE THAT BILIVERDIN-IX BETA REDUCTASE AND FLAVIN REDUCTASE ARE IDENTICAL, BIOCHEMICAL JOURNAL, 316, 1996, p385 - 387
Murphy, K.C., Graham, M., Mantle, T & Shelley R.K., Schizophrenia, lung cancer and glutathione S-transferase Mu, Irish J. Psych. Med, 13, 1996, p138 - 139
MANTLE, TJ, THE GLUTATHIONE-S-TRANSFERASE MULTIGENE FAMILY - A PARADIGM FOR XENOBIOTIC INTERACTIONS, BIOCHEMICAL SOCIETY TRANSACTIONS, 23, 1995, p423 - 425
ENNIS, OM, MANTLE, T, EXPRESSION OF RAT BILIVERDIN REDUCTASE AS A GLUTATHIONE-S-TRANSFERASE FUSION PROTEIN, BIOCHEMICAL SOCIETY TRANSACTIONS, 23, 1995, S443 - S443
WALSH, SB, MANTLE, TJ, MODIFICATION OF MOUSE-LIVER GLUTATHIONE-S-TRANSFERASE-PI BY IODOACETIC ACID, BIOCHEMICAL SOCIETY TRANSACTIONS, 23, 1995, S485 - S485
ELLIOTT, G, MANTLE, TJ, PURIFICATION AND PROPERTIES OF SALMON LIVER BILIVERDIN REDUCTASE, BIOCHEMICAL SOCIETY TRANSACTIONS, 23, 1995, pS389 - S389
MAHMUD, N, STINSON, J, OCONNELL, MA, MANTLE, TJ, KEELING, PWN, FEELY, J, WEIR, DG, KELLEHER, D, MICROALBUMINURIA IN INFLAMMATORY BOWEL-DISEASE, GUT, 35, 1994, p1599 - 1604
GARCIASAEZ, I, PARRAGA, A, PHILLIPS, MF, MANTLE, TJ, COLL, M, MOLECULAR-STRUCTURE AT 1-CENTER-DOT-8-ANGSTROM OF MOUSE-LIVER CLASS-PI GLUTATHIONE-S-TRANSFERASE COMPLEXED WITH S-(P-NITROBENZYL)GLUTATHIONE AND OTHER INHIBITORS, JOURNAL OF MOLECULAR BIOLOGY, 237, 1994, p298 - 314
PHILLIPS, MF, MANTLE, TJ, INACTIVATION OF MOUSE-LIVER GLUTATHIONE-S-TRANSFERASE YFYF (PI CLASS) BY ETHACRYNIC-ACID AND 5,5'-DITHIOBIS-(2-NITROBENZOIC ACID), BIOCHEMICAL JOURNAL, 294, 1993, p57 - 62
KD Tew, CB Pickett, TJ Mantle, B Mannervik & JD Hayes (eds), Structure and Function of Glutathione S-transferases, Ann Arbor, London & Tokyo, CRC Press Boca Raton, 1993
BOYCE, SJ, MANTLE, TJ, EFFECT OF LEAD ACETATE AND CARBON PARTICLES ON THE EXPRESSION OF GLUTATHIONE-S-TRANSFERASE YFYF IN RAT-LIVER, BIOCHEMICAL JOURNAL, 294, 1993, p301 - 304
RYAN, J, MANTLE, T, MCQUAID, S, COSTIGAN, DC, SALIVARY INSULIN-LIKE GROWTH FACTOR-I ORIGINATES FROM LOCAL SYNTHESIS, JOURNAL OF ENDOCRINOLOGY, 135, 1992, p85 - &
RYAN, J, MANTLE, T, COSTIGAN, DC, A NORMAL POPULATION STUDY OF HUMAN SALIVARY INSULIN-LIKE GROWTH FACTOR-I (IGF-1) CONCENTRATIONS FROM BIRTH THROUGH PUBERTY, JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 74, 1992, p774 - 778
RYAN, J, COMPARISON OF TYPE-1 INSULIN-LIKE GROWTH-FACTOR (IGF) RECEPTOR-BINDING IN OVINE TISSUE AND HUMAN PLACENTAL MEMBRANES, Biochem. Soc. Trans, 1991, 19, 1991, ppS63 - S63
PHILLIPS, MF, MANTLE, TJ, THE INITIAL-RATE KINETICS OF MOUSE GLUTATHIONE-S-TRANSFERASE YFYF - EVIDENCE FOR AN ALLOSTERIC SITE FOR ETHACRYNIC-ACID, BIOCHEMICAL JOURNAL, 275, 1991, p703 - 709
K.F. Tipton & T.J. Mantle (eds), Amine Oxidases: Structure, Function and Expression, Biochem. Soc. Trans., 19, 1991, pp199 - 233
MANTLE, TJ, MCCUSKER, FM, PHILLIPS, M, BOYCE, S, GLUTATHIONE S-TRANSFERASES, BIOCHEMICAL SOCIETY TRANSACTIONS, 18, 1990, p175 - 177
RYAN, J, ASSOCIATION OF PLASMA INSULIN-LIKE GROWTH FACTOR-I CARRIER PROTEIN INVIVO, Biochem. Soc. Trans., 1990, 18, 1990, pp335 - 336
Some immunocytochemical and other recent studies on rodent glutathione S-transferases in, editor(s)J.D. Hayes, C.B. Pickett & T.J. Mantle , Glutathione S-transferases and drug resistance, London, Philadelphia and New York, Taylor and Francis, 1989, [McCusker, F.M., Phillips, M.F., Boyce, S.J. & Mantle, T.J.]
Contributions of glutathione S-transferase to drug resistance in nature in, editor(s)J.D. Hayes, C.B. Pickett & T.J. Mantle , Glutathione S-transferases and drug resistance, London, Philadelphia and New York, Taylor and Francis, 1989, [Hayes, J.D., Pickett, C.B. & Mantle, T.J.]
J.D. Hayes, T.J. Mantle & C.B. Pickett (eds), Glutathione S-transferases and Drug Resistance, London, New York and Philadelphia , Taylor and Francis, 1989
RIGNEY, E, MANTLE, TJ, DICKINSON, FM, THE KINETICS OF OX KIDNEY BILIVERDIN REDUCTASE IN THE PRE-STEADY STATE - EVIDENCE THAT THE DISSOCIATION OF BILIRUBIN IS THE RATE-DETERMINING STEP, BIOCHEMICAL JOURNAL, 259, 1989, p709 - 713
Roy, A.B. & Mantle, T.J., The anomalous kinetics of sulphatase A, Biochem. J., 261, 1989, p689 - 697
RYAN, J, SALIVARY SOMATOMEDIN C INSULIN-LIKE GROWTH FACTOR-I - EVIDENCE OF LOCAL PRODUCTION, Biochem. Soc. Trans., 1989, 17, 1989, pp610 - 610
GRAHAM, MN, MANTLE, TJ, PURIFICATION OF A CLASS-C A-TYPE BETA-LACTAMASE FROM A DEREPRESSED STRAIN OF ENTEROBACTER-CLOACAE - COMPARISON OF THE WILD-TYPE AND MUTANT ENZYME WITH THOSE FROM STRAIN-P99, STRAIN-208 AND STRAIN-GN7471, BIOCHEMICAL JOURNAL, 260, 1989, p705 - 710
MCCUSKER, FMG, BOYCE, SJ, MANTLE, TJ, THE DEVELOPMENT OF GLUTATHIONE S-TRANSFERASE SUBUNITS IN RAT-LIVER - SENSITIVE DETECTION OF THE MAJOR SUBUNIT FORMS OF RAT GLUTATHIONE S-TRANSFERASE BY USING AN ELISA METHOD, BIOCHEMICAL JOURNAL, 262, 1989, p463 - 467
ROY, AB, THE ANOMALOUS KINETICS OF SULFATASE-A, by MANTLE, TJ , BIOCHEMICAL JOURNAL, 261, 1989, p689 - 697
RIGNEY, EM, CHLORIDE ABOLISHES FLUX THROUGH THE SUBSTRATE-INHIBITION PATHWAY OF BILIVERDIN REDUCTASE, Biochem. Soc. Trans., 1988, 16, I, 1988, pp403 - 404
GRAHAM, MN, KINETIC-PROPERTIES OF A DEREPRESSED BETA-LACTAMASE FROM ENTEROBACTER-CLOACAE, Biochem. Soc. Trans., 1988, 16, 1988, pp404 - 405
RIGNEY, EM, PHILLIPS, O, MANTLE, TJ, SOME PHYSICAL AND IMMUNOLOGICAL PROPERTIES OF OX KIDNEY BILIVERDIN REDUCTASE, BIOCHEMICAL JOURNAL, 255, 1988, p431 - 435
BOYCE, SJ, IMMUNOCYTOCHEMICAL LOCALIZATION OF GLUTATHIONE S-TRANSFERASE SUBUNITS IN RAT-BRAIN, Biochem. Soc. Trans., 1988, 16, 1988, pp386 - 387
Graham, M.N. & Mantle, T.J., Kinetic properties of a de-repressed -lactamase from Enterobacter cloacae, Biochem. Soc. Trans., 16, 1988, p404 - 405
RIGNEY, E, MANTLE, TJ, THE REACTION-MECHANISM OF BOVINE KIDNEY BILIVERDIN REDUCTASE, BIOCHIMICA ET BIOPHYSICA ACTA, 957, 1988, p237 - 242
T.J. Mantle, C.B. Pickett & J.D. Hayes (eds), Glutathione S-transferases and Carcinogenesis, London, New York and Philadelphia , Taylor and Francis, 1987
Glutathione S-transferase heterogeneity: novel forms or sticky artefacts ? in, editor(s)T.J. Mantle, C.B. Pickett and J.D. Hayes , Glutathione S-transferases and carcinogenesis, London, New York and Philadelphia, Taylor and Francis, 1987, pp65 - 67, [McCusker, F.M. & Mantle, T.J.]
MCCUSKER, FM, ISOLATION OF GLUTATHIONE S-TRANSFERASE-G FROM RAT-LIVER, Biochem. Soc. Trans., 1987, 15, 1987, pp222 - 222
Tissue distribution of glutathione S-transferase subunits in rodents: an immunocytochemical study in, editor(s)T.J. Mantle, C.B. Pickett and J.D. Hayes , Glutathione S-transferases and carcinogenesis, London, New York and Philadelphia, Taylor and Francis, 1987, ppDD - DD, [Boyce, S.J., McBennett, S.M., Mantle, T.J. & Hayes, J.D.]
HAYES, JD, COULTHWAITE, RE, STOCKMAN, PK, HUSSEY, AJ, MANTLE, TJ, WOLF, CR, GLUTATHIONE-S-TRANSFERASE SUBUNITS IN THE MOUSE AND THEIR CATALYTIC ACTIVITIES TOWARDS REACTIVE ELECTROPHILES, ARCHIVES OF TOXICOLOGY, 1987, p136 - 146
Hayes, J.D. & Mantle, T.J., Inhibition of hepatic and extrahepatic glutathione S-transferases by primary and secondary bile acids, Biochem. J., 233, 1986, p407 - 415
T.J. Mantle (ed), Roles and Functions of Glutathione, Biochem. Soc. Trans. , 15, 1986, pp717 - 736
Worrall, D.M., Daly, A.K. & Mantle, T.J., Kinetic studies on the major form of aldehyde reductase in ox kidney: a general kinetic mechanism to explain substrate dependent mechanisms and the inhibition by anticonvulsants, J. Enz. Inhib., 1, 1986, p163 - 168
HAYES, JD, MANTLE, TJ, ANOMALOUS ELECTROPHORETIC BEHAVIOR OF THE GLUTATHIONE-S-TRANSFERASE YA AND YK SUBUNITS ISOLATED FROM MAN AND RODENTS - A POTENTIAL PITFALL FOR NOMENCLATURE, BIOCHEMICAL JOURNAL, 237, 1986, p731 - 740
Hayes, J.D. & Mantle, T.J., Use of immuno-blot techniques to discriminate between the glutathione S-transferase Yf, Yk, Ya, Yn/Yb and Yc subunits and to study their distribution in extrahepatic tissues. Evidence for three immunochemically distinct groups of transferase in the rat, Biochem. J., 233, 1986, p779 - 788
GRAHAM, MN, PARTIAL-PURIFICATION OF MYOINOSITOL OXYGENASE FROM OX KIDNEY BY USING PHENYL-SEPHAROSE, Biochem. Soc. Trans., 1985, 13, 1985, pp481 - 481
HEYENGA, AG, THE DETERMINATION OF GLUCURONIC AND GULONIC ACID BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY, Biochem. Soc. Trans., 1985, 13, 1985, pp483 - 484
RIGNEY, EM, NUCLEOTIDE BINDING TO OX KIDNEY BILIVERDIN REDUCTASE, Biochem. Soc. Trans., 1985, 13, 1985, pp502 - 502
SHEEHAN, D, RYLE, CM, MANTLE, TJ, SELECTIVE INDUCTION OF GLUTATHIONE S-TRANSFERASE-D IN RAT TESTIS BY PHENOBARBITAL, BIOCHEMICAL JOURNAL, 219, 1984, p687 - 688
SHEEHAN, D, MANTLE, TJ, EVIDENCE FOR 2 FORMS OF LIGANDIN (YAYA DIMERS OF GLUTATHIONE S-TRANSFERASE) IN RAT-LIVER AND KIDNEY, BIOCHEMICAL JOURNAL, 218, 1984, p893 - 897
PHILLIPS, O, MANTLE, TJ, TUFFERY, AR, HEYWORTH, CM, WILSON, SR, HOUSLAY, MD, ON THE POSSIBLE ROLE OF BILIVERDIN STIMULATION OF CYCLIC-AMP LEVELS AS A TRIGGER FOR LIVER-REGENERATION IN THE RAT, BIOCHEMICAL PHARMACOLOGY, 33, 1984, p1963 - 1967
Determination of the relative molecular mass of proteins by gel filtration, density gradient centrifugation, sedimentation equilibrium in the airfuge, radiation inactivation and polyacrylamide electrophoresis in, editor(s)K.F. Tipton , Techniques in the life sciences, Shannon, Ireland, Elsevier Scientific Publishers Ireland Ltd., 1984, pp1 - 26, [Mantle, T.J.]
RYLE, CM, MANTLE, TJ, STUDIES ON THE GLUTATHIONE S-TRANSFERASE ACTIVITY ASSOCIATED WITH RAT-LIVER MITOCHONDRIA, BIOCHEMICAL JOURNAL, 222, 1984, p553 - 556
BUTLER, BM, THE EFFECT OF PH ON THE SLOW KINETIC TRANSIENTS OF ARYLSULFATASE-A, Biochem. Soc. Trans., 1984, 12, 1984, pp468 - 468
Sheehan, D. & Mantle, T.J., Isolation of the major cyanogen bromide cleavage fragment of the a- and c-subunits of glutathione S-transferases AA, B and ligandin, Biochem. Soc. Trans., 11, 1983, p353 - 354
Sheehan, D. & Mantle, T.J., The nomenclature of the multiple forms of glutathione S-transferase in the rat, Biochem. Soc. Trans., 11, 1983, p353 - 353
Tipton, K.F., O'Carroll, A.-M., Mantle, T.J. & Fowler, C.J., Factors involved in the selective inhibition of monoamine oxidase, Mod. Probl. Pharmacopsychtiat., 19, 1983, p15 - 30
OFAGAIN, C, BUTLER, BM, MANTLE, TJ, THE EFFECT OF PH ON THE KINETICS OF ARYLSULFATASE-A AND ARYLSULFATASE-B, BIOCHEMICAL JOURNAL, 213, 1983, p603 - 607
Monoamine oxidase A and B: time for re-evaluation in, editor(s)S. Kalsner , Trends in autonomic pharmacology; vol. 2, Baltimore , Urban & Schwarzenburg, 1982, pp523 - 542, [Mantle, T.J. & Tipton, K.F.]
Sheehan, D. & Mantle, T.J., Glutathione S-transferases AA and B possess a common antigenic determinant, Biochem. Soc. Trans., 10, 1982, p113 - 113
Tipton, K.F., Rivett, A.J., Daly, A.K. & Mantle, T.J., Kinetic studies with aldehyde reductases, Prog. Clin. Biol. Res., 114, 1982, p197 - 208
OFAGAIN, C, BOND, U, ORSI, BA, MANTLE, TJ, THE SLOW KINETIC TRANSIENTS OF ARYLSULFATASE-A, BIOCHEMICAL JOURNAL, 201, 1982, p345 - 352
DALY, AK, MANTLE, TJ, PURIFICATION AND CHARACTERIZATION OF THE MULTIPLE FORMS OF ALDEHYDE REDUCTASE IN OX KIDNEY, BIOCHEMICAL JOURNAL, 205, 1982, p373 - 380
DALY, AK, MANTLE, TJ, THE KINETIC MECHANISM OF THE MAJOR FORM OF OX KIDNEY ALDEHYDE REDUCTASE WITH D-GLUCURONIC ACID, BIOCHEMICAL JOURNAL, 205, 1982, p381 - 388
Kinetic studies with aldehyde reductases in, editor(s)H. Weiner and B. Wermuth , Enzymology of carbonyl metabolism: Aldehyde dehydrogenase and aldo/keto reductase, New York, Alan R. Liss, Inc., 1982, pp197 - 208, [Tipton, K.F., Rivett, A.J., Daly, A.K. & Mantle, T.J.]
FOWLER, CJ, MANTLE, TJ, TIPTON, KF, THE NATURE OF THE INHIBITION OF RAT-LIVER MONOAMINE-OXIDASE TYPE-A AND TYPE-B BY THE ACETYLENIC INHIBITORS CLORGYLINE, L-DEPRENYL AND PARGYLINE, BIOCHEMICAL PHARMACOLOGY, 31, 1982, p3555 - 3561
SCULLY, NC, MANTLE, TJ, TISSUE DISTRIBUTION AND SUBUNIT STRUCTURES OF THE MULTIPLE FORMS OF GLUTATHIONE S-TRANSFERASE IN THE RAT, BIOCHEMICAL JOURNAL, 193, 1981, p367 - 370
The inhibition of rat liver monoamine oxidase by clorgyline and deprenyl in, editor(s)M.B.H. Youdim and E.S. Paykel , Monoamine oxidase inhibitors - The State of the Art, Chichester, U.K., John Wiley & Sons Ltd., 1981, pp3 - 15, [Tipton, K.F. & Mantle, T.J.]
T.J. Mantle (ed), Monomeric NAD(P)-linked oxidoreductases, Biochem. Soc. Trans., 9, 1981, pp271 - 282
Phillips, O. & Mantle, T.J., Some kinetic and physical properties of biliverdin reductase, Biochem. Soc. Trans., 9, 1981, p275 - 278
Scully, N.C. & Mantle, T.J., The identity of the c-subunits of glutathione S-transferases AA and B, Biochem. Soc. Trans., 1981, p296 - 296
Daly, A.K. & Mantle, T.J., Multiple forms of aldehyde reductase from ox kidney, Biochem. Soc. Trans., 9, 1981, p295 - 295
Fowler, C.J., Callingham, B.A., Mantle, T.J. & Tipton, K.F., The effect of lipophilic compounds upon the activity of rat liver monoamine oxidase-A and -B, Biochem. Pharmacol., 29, 1980, p1173 - 1183
Scully, N.C. & Mantle, T.J., Studies on the nature of the multiple forms of the glutathione S-transferases, Biochem. Soc. Trans., 8, 1980, p451 - 452
O'Fagain, C., Burke, J. & Mantle, T.J., Inhibition of arylsulphatases A and B by nucleotides and other anions, Biochem. Soc. Trans., 8, 1980, p450 - 451
Molecular weight determination by gel filtration, density gradient centrifugation, electrophoresis and irradiation inactivation in, Techniques in the Life Sciences, B1/1, Elsevier/North Holland, Biomedical Press, 1979, [Mantle, T.J.]
Barnard, E.A., Dolly, J.O., Lo, M. & Mantle, T.J., Biochem. Soc. Trans., 6, 1978, p649 - 651
Callingham, B.A., Fowler, C.J., Mantle, T.J. & Tipton, K.F., Monoamine oxidase A and B; a useful concept ?, Biochem. Pharmacol., 27, 1978, p97 - 101
Tipton, K.F., Houslay, M.D. & Mantle, T.J., A kinetic method for the detection of inhibitory contaminants in radioactive substrates, Biochem. Pharmacol., 26, 1977, p1525 - 1527
Dynamics of monoamine oxidase in, editor(s)E. Usdin, N. Weiner and M.B.H. Youdim , Structure and Function of Monoamine Enzymes, 1977, pp559 - 585, [Tipton, K.F. & Mantle, T.J.]
Tipton, K.F. & Mantle, T.J., Selective inhibition of monoamine oxidase, Abstracts VI World Congress of Psychiatry, 1977, p64 - 64
Mantle, T.J., Houslay, M.D., Garrett, N.J. & Tipton, K.F., 5-Hydroxy tryptamine is a substrate for both species of monoamine oxidase in beef heart mitochondria, J. Pharm. Pharmac., 28, 1976, p667 - 671
Tipton, K.F., Mantle, T.J. & Houslay, M.D., Some problems concerning the apparent multiplicity of monoamine oxidase, Psychopharmacol. Bull., 1976
Mantle, T.J., Tipton, K.F. & Garrett, N.J., Inhibition of monoamine oxidase by amphetamine and related compounds, Biochem. Pharmacol., 25, 1976, p2073 - 2077
Long, R.F., Mantle, T.J. & Wilson, K., Substrate-selective inhibition of monoamine oxidase by some cyclopropylamino substituted oxadiazoles, Biochem. Pharmacol., 25, 1976, p247 - 252
Mantle, T.J., Wilson, K. & Long, R.F., Studies on the selective inhibition of membrane-bound rat liver monoamine oxidase, Biochem. Pharmacol., 24, 1975, p2039 - 2046
Mantle, T.J., Garrett, N.J. & Tipton, K.F., The development of monoamine oxidase in rat liver and brain, FEBS Letts., 64, 1975, p227 - 230
Mantle, T.J., Kinetic studies on rat liver monoamine oxidase, C.N.A.A., 1974
Non-Peer-Reviewed Publications
Mantle, T.J., Enzymes: nature's exquisite nanomachines. A tale of two transients and some floppy bits, Royal Irish Academy, Dublin, 1999
Tipton, K.F. & Mantle, T.J., Selective inhibition and the multiplicity of monoamine oxidase, Second World Congress of Biological Psychiatry, Barcelona, 1978
Tipton, K.F., Houslay, M.D. & Mantle, T.J., The nature and locations of the multiple forms of monoamine oxidase, Ciba Foundation Symposium: "Monoamine oxidase and its inhibition", Excerpta Medica, North Holland, 1976, pp5 - 16
Research Expertise
Description
. CURRENT RESEARCH INTERESTS: Research in the Molecular Enzymology Group centres on structural, kinetic and regulatory aspects of a number of enzymes. . BILIVERDIN-IX REDUCTASE AS A PHARMACOLOGICAL TARGET FOR NEONATAL JAUNDICE. . STRUCTURAL AND KINETIC STUDIES ON GST-P1-1. . . BILVERDIN REDUCTASE AND THE ANTIOXIDANT RESPONSE. . THE TRANSIENT KINETICS OF SULPHATASE A. . FINANCIAL SUPPORT: SFI, Enterprise Ireland (Proof of Concept), HRB, IACR, PRTLI . MAJOR COLLABORATORS: Miquel Coll (Barcelona), John Hayes (Dundee), Mike Gore (Southampton), Phil Board (Canberra), Pedro Pereira (Porto).Projects
- Funding Agency
- MRC (UK)
- Funding Agency
- Wellcome Trust (UK)
- Funding Agency
- NIH (USA)
- Funding Agency
- AICR (UK)
Recognition
Representations
Editorial Board of the Biochemical Journal
Elected Secretary of the Molecular and Cellular Pharmacology Group of the Biochemical Society.
Director, National Pharmaceutical Biotechnology Centre, Trinity College, Dublin
Editorial Adviser: Biochemical Journal; Biochim. Biophys. Acta; Eur. J. Biochem; Diabetologia
Editor: Glutathione S-transferases and Carcinogenesis, Taylor and Francis
Editor: Glutathione S-transferases and Drug Resistance, Taylor and Francis
Editor: Structure and function of glutathione S-transferases, CRC Press
Awards and Honours
Elected Fellow of Trinity College
Royal Irish Academy's Medal for Biochemistry
Memberships
Nominated to the National Committee for Biochemistry (of the Royal Irish Academy)
European Environmental Mutagen Society: Councillor for Ireland
Biochemical Society: Editorial Board,Biochemical Journal
Biochemical Society: Elected to the Molecular and Cellular Pharmacology Group
Biochemical Society: Elected to the Molecular Enzymology Group
Biochemical Society: Elected to Irish Area Section Committee
Biochemical Society (Member)
Director, National Pharmaceutical Biotechnology Centre, Trinity College, Dublin