Dr. Kenneth Hun Mok
Associate Professor, Biochemistry

James C.S. Ho and Ines Ambite and K. H. Mok and Marek Babjuk and Catharina Svanborg, A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate, Molecular & Cellular Oncology, 8, (5), 2021 Journal Article, 2021 DOI

Sherlock, L. and Mok, K. H., Metabolomics and Its Applications to Personalized Medicine, EKC 2019 Conference Proceedings, EKC 2019, Vienna, Austria, 2019, edited by Park, J. M. and Whang, D. R. , Springer Nature Singapore Pte Ltd, 2021, pp25 - 42 Conference Paper, 2021 DOI

Sinevici N, Harte N, O'Grady I, Xie Y, Min S, Hun Mok K, O'Sullivan J., The novel therapeutic potential of bovine "-lactalbumin made lethal to tumour cells and oleic acid in oral squamous cell carcinoma., European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2020 Journal Article, 2020 DOI

Do-Hyoung Kim, Jongchan Lee, K. Mok, Jung Lee, Kyou-Hoon Han, Salient Features of Monomeric Alpha-Synuclein Revealed by NMR Spectroscopy, Biomolecules, 10, (3), 2020, p428 Journal Article, 2020 DOI

Koh D, Jung Y, Ahn S, Mok KH, Shin SY, Lim Y, Synthesis and structure elucidation of polyphenols containing the N'-methyleneformohydrazide scaffold as aurora kinase inhibitors., Magnetic resonance in chemistry : MRC, 2017 Journal Article, 2017 DOI

Kinoshita M, Kim JY, Kume S, Lin Y, Mok KH, Kataoka Y, Ishimori K, Markova N, Kurisu G, Hase T, Lee Y-H, Energetic basis on interactions between ferredoxin and ferredoxin NADP+ reductase at varying physiological conditions, Biochemistry Biophysics Research Communications, 482, (4), 2017, p909 - 915 Journal Article, 2017

McGettrick AF, Corcoran SE, Barry PJG, McFarland J, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LAJ, Nolan DP, The Trypanosoma brucei metabolite indolepyruvate decreases HIF-1 and glycolysis in macrophages as a mechanism of innate immune evasion, Proceedings of the National Academy of Sciences, U.S.A., 113, (48), 2016, pE7778 - E7787 Journal Article, 2016 URL

Abbas SN, Mok KH, Rashid N, Xie Y, Ruether M, O'Brien J, Akhtar M, NMR studies on mechanism of isomerisation of fructose 6-phosphate to glucose 6-phosphate catalysed by phosphoglucose isomerase from Thermococcus kodakarensis, Bioorganic Chemistry, 66, 2016, p41 - 45 Journal Article, 2016

Svanborg C, Mok KH, Trulsson M, Mossberg A-K, Storm P, Ho CS, 'Biologically active complex and its preparation', European Patent Office, EP 2 643 010 B1, 2016, HAMLET Pharma AB Patent, 2016 Other

Narciandi, F. and Fernandez-Fuertes, B. and Khairulzaman, I. and Jahns, H. and King, D. and Finlay, E.K. and Mok, K.H. and Fair, S. and Lonergan, P. and O'Farrelly, C. and Meade, K.G., Sperm-coating beta-defensin 126 is a dissociation-resistant dimer produced by epididymal epithelium in the bovine reproductive tract, Biology of Reproduction, 95, (6), 2016, p1-9 Journal Article, 2016 DOI

Kim KH, Yun S, Mok KH, Lee EK, Thermodynamic analysis of ANS binding to partially unfolded α-lactalbumin: correlation of endothermic to exothermic changeover with formation of authentic molten globules, Journal of Molecular Recognition, 29, 2016, p446 - 451 Journal Article, 2016

McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP, Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion., Proc Natl Acad Sci U S A. , 113, (48), 2016, E7778-E7787 Journal Article, 2016 DOI

Al-Ani B, Fitzpatrick M, Al-Nuaimi H, Coughlan A.M, Hickey F.B, Pusey C.D, Savage C, Benton C.M, O'Brien E.C, O'Toole D, Mok K.H, Young S.P, Little M.A, Changes in urinary metabolomic profile during relapsing renal vasculitis, Scientific Reports, 6, 2016, 38074 - Journal Article, 2016 TARA - Full Text DOI URL

Harte NP, Klyubin I, McCarthy EK, Min S, Garrahy SA, Xie Y, Davey GP, Boland JJ, Rowan MJ, Mok KH, Amyloid Oligomers and Mature Fibrils Prepared from an Innocuous Protein Cause Diverging Cellular Death Mechanisms, Journal of Biological Chemistry, 290, (47), 2015, p28343 - 28352 Journal Article, 2015 URL

Sullivan, L.M., Kehoe, J.J., Barry, L., Buckley, M.J.M., Shanahan, F., Mok, K.H., Brodkorb, A., Gastric digestion of "-lactalbumin in adult human subjects using capsule endoscopy and nasogastric tube sampling, British Journal of Nutrition, 112, (4), 2014, p638-646 Journal Article, 2014 DOI

Kehoe, J.J., Lišková, K., Mok, K.H., O'Brien, N., Kelly, A.L., Brodkorb, A., Formation of cytotoxic "-lactalbumin / sodium oleate complexes: Concentration and temperature effects, International Dairy Journal, 38, (1), 2014, p65-73 Journal Article, 2014 DOI

Tynan GA, Hearnden CH, Oleszycka E, Lyons CL, Coutts G, O'Connell J, Corrigan MA, Lynch L, Campbell M, Callanan JJ, Mok KH, Geoghegan J, O'Farrelly C, Allan SM, Roche HM, O'Shea DB, Lavelle EC, Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1 alpha-dependent inflammation., Diabetes, 63, (3), 2014, p2037-2050 Journal Article, 2014 DOI TARA - Full Text

Tynan, GA, Hearnden, CH, Oleszycka, E, Lyons, CL, Coutts, G, O'Connell, J, Corrigan, MA, Lynch, L, Campbell, M, Callanan, JJ, Mok, KH, Geoghegan, J, O'Farrelly, C, Allan, SM, Roche, HM, O'Shea, DB, Lavelle, EC, Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1 alpha-Dependent Inflammation, Diabetes, 63, (6), 2014, p2037-2050 Journal Article, 2014 TARA - Full Text DOI

Korean Immigrant Experiences in America and in Ireland: Breaking the Vicious Circle of Ethnic Patterns in, editor(s)Bertoni R , Quaderni di cultura, Volume 11, Turin, Italy, Trinity College Dublin and Trauben Edizioni, 2014, pp107 - 121, [Mok KH] Book Chapter, 2014 TARA - Full Text

Rehman, S, Ikram, M, Khan, A, Min, S, Azad, E, Hofer, TS, Mok, KH, Baker, RJ, Blake, AJ, Rehman, SU, New dicoumarol sodium compound: crystal structure, theoretical study and tumoricidal activity against osteoblast cancer cells, Chemistry Central Journal, 7, 2013, p110- Journal Article, 2013 TARA - Full Text DOI

Xie, Y., Min, S., Harte, N.P., Kirk, H., O'Brien, J.E., Voorheis, H.P., Svanborg, C., Hun Mok, K., Electrostatic interactions play an essential role in the binding of oleic acid with α-lactalbumin in the HAMLET-like complex: A study using charge-specific chemical modifications, Proteins: Structure, Function and Bioinformatics, 81, (1), 2013, p1-17 Journal Article, 2013 DOI

Rehman, S., Ikram, M., Baker, R.J., Zubair, M., Azad, E., Min, S., Riaz, K., Mok, K.H., Rehman, S.-U., Synthesis, characterization, in vitro antimicrobial, and U2OS tumoricidal activities of different coumarin derivatives, Chemistry Central Journal, 7, (1), 2013, p68- Journal Article, 2013 DOI

Wetterling, Mok, McGoldrick, Basu, Non-Destructive Investigation of Glass Fiber Reinforced Composites via Magnetic Resonance Imaging, Key Engineering Materials, 569-570, 2013, p126 - 131 Journal Article, 2013 DOI URL

Ho, J.C.S., Storm, P., Rydström, A., Bowen, B., Alsin, F., Sullivan, L., Ambite, I., Mok, K.H., Northen, T., Svanborg, C., Lipids as tumoricidal components of human α-lactalbumin made lethal to tumor cells (HAMLET): Unique and shared effects on signaling and death, Journal of Biological Chemistry, 288, (24), 2013, p17460-17471 Journal Article, 2013 DOI

Rehman, S., Ikram, M., Khan, A., Min, S., Azad, E., Hofer, T.S., Mok, K.H., Baker, R.J., Blake, A.J., Rehman, S.U., New dicoumarol sodium compound: Crystal structure, theoretical study and tumoricidal activity against osteoblast cancer cells, Chemistry Central Journal, 7, (1), 2013, p110- Journal Article, 2013 DOI

Sullivan, L.M., Mok, K.H., Brodkorb, A., The formation of an anti-cancer complex under simulated gastric conditions, Food Digestion, 4, (1), 2013, p7-18 Journal Article, 2013 DOI

Min, SY, Meehan, J, Sullivan, LM, Harte, NP, Xie, YJ, Davey, GP, Svanborg, C, Brodkorb, A, Mok, KH, Alternatively folded proteins with unexpected beneficial functions, Biochemical Society Transactions, 40, 2012, p746-751 Journal Article, 2012 DOI

Li ková K, Auty MAE, Chaurin V, Min S, Mok KH, O'Brien N, Kelly AL, Brodkorb, A, Cytotoxic complexes of sodium oleate with β-lactoglobulin., European Journal of Lipid Science and Technolology, 113, (10), 2011, p1207 - 1218 Journal Article, 2011 DOI

Ivanov, KL, Lukzen, NN, Morozova, OB, Mok, KH, Yurkovskaya, AV, Quantitative Approach to CIDNP in Proteins with Several Polarizable Residues on the Surface, Applied Magnetic Resonance , 41, 2011, 251-266 Journal Article, 2011 DOI

Mok KH (Inventor), Mok KH (Assignee), A pharmaceutical composition comprising a retro-inverso isomer peptide, 2010, Registered Republic of Korea Patent No. 2003-32468 Patent, 2010

Mossberg A, Mok KH, Morozova-Roche LA, Svanborg C, Structure and function of human α-lactalbumin made lethal to tumour cells (HAMLET)-type complexes, FEBS Journal, 277, (22), 2010, p4614 - 4625 Journal Article, 2010 DOI

Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nuñez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA, Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1ß in type 2 diabetes., Nature immunology, 11, (10), 2010, p897-904 Journal Article, 2010

Yoon JW, Wilson SP, Mok KH, A highly efficient blocked Gibbs sampler reconstruction of multidimensional NMR spectra, Journal of Machine Learning Research, Workshop & Conference Proceedings, 13th International Conference on Artificial Intelligence and Statistics (AISTATS), Chia Laguna Resort, Sardinia, Italy, 13-15 May 2010, edited by Yee Whye Teh, Mike Titterington , 9, 2010, pp940 - 947 Conference Paper, 2010 TARA - Full Text URL

Pettersson-Kastberg, J., Mossberg, A.-K., Trulsson, M., Yong, Y.J., Min, S., Lim, Y., O'Brien, J.E., Svanborg, C., Mok, K.H., "-Lactalbumin, Engineered to be Nonnative and Inactive, Kills Tumor Cells when in Complex with Oleic Acid: A New Biological Function Resulting from Partial Unfolding, Journal of Molecular Biology, 394, (5), 2009, p994-1010 Journal Article, 2009 DOI

Bernard E, Parthsarathi L, Cho M-K, Aylward K, Raab M, Daxecker H, O'Dushlaine CT, Shields DC, Devocelle M, Keyes T, Cosgrave L, O'Neill S, Mok KH, Moran N, Ligand Switching in Cell-Permeable Peptides: Manipultation of the alpha integrin signature motif, ACS Chemical Biology, 4, (6), 2009, p457 - 471 Journal Article, 2009 DOI

Pettersson-Kastberg J, Mossberg AK, Trulsson M, Yong YJ, Min S, Lim Y, O'Brien JE, Svanborg C, Mok KH, Alpha-Lactalbumin, engineered to be nonnative and inactive, kills tumor cells when in complex with oleic acid: a new biological function resulting from partial unfolding, Journal of Molecular Biology, 394, (5), 2009, p994 - 1010 Journal Article, 2009 DOI

Gattin Z, Riniker S, Hore PJ, Mok KH, van Gunsteren WF, Temperature and urea induced denaturation of the TRP-cage mini protein TC5b: A simulation study consistent with experimental observations, Protein Science, 18, (10), 2009, p2090 - 2099 Journal Article, 2009 DOI

Day IJ, Maeda K, Paisley HJ, Mok KH, Hore PJ, Refolding of RNase A monitord by real-time photo-CIDNP NMR spectroscopy, Journal of Biomolecular NMR, 44, (2), 2009, p77 - 86 Journal Article, 2009 DOI

Pettersson-Kastberg J, Aits S, Gustafsson L, Mossberg A-K, Storm P, Trulsson M, Persson F, Mok KH, Svanborg C, Can misfolded proteins be beneficial? The HAMLET case. (Review), Annals of Medicine, 41, (3), 2009, p162 - 176 Journal Article, 2009 DOI

Wilhelm K, Darinskas A, Noppe W, Duchardt E, Mok KH, Vukojević V, Schleucher J, Morozova-Roche LA, Protein oligomerization induced by oleic acid at the solid-liquid interface--equine lysozyme cytotoxic complexes, FEBS Journal, 276, (15), 2009, p3975 - 3989 Journal Article, 2009 DOI

Mok KH (Inventor), Mok KH (Assignee), A pharmaceutical composition comprising a retro-inverso isomer peptide, 2008, US Patent No. 7,314,867 (1 Jan 2008) Patent, 2008

Mok KH, Kuhn LT, Goez M, Day IJ, Lin JC, Andersen NH, Hore PJ, A pre-existing hydrophobic collapse in the unfolded state of an ultrafast folding protein, Nature, 447, (7140), 2007, p106 - 109 Journal Article, 2007 URL DOI

Mok KH (Inventor), Mok KH (Assignee), Pharmazeutische Zusammensetzung mit einem Retro-Inverso Isomerpeptid, 2007, Deutsches Patent DE 60308710 Patent, 2007

Mok KH, Pettersson J, Orrenius S, Svanborg C, HAMLET, protein folding, and tumour cell death (Mini review), Biochemical and Biophysical Research Communications, 354, (1), 2007, p1 - 7 Journal Article, 2007 DOI

Mok, K.H., Pettersson, J., Orrenius, S., Svanborg, C., HAMLET, protein folding, and tumor cell death, Biochemical and Biophysical Research Communications, 354, (1), 2007, p1-7 Journal Article, 2007 DOI

Mok KH (Inventor), Mok KH (Assignee), Pharmaceutical composition comprising a retro-inverso isomer peptide, 2006, Irish Patent Register No. 1549334 (27 Sep 2006) Patent, 2006

Mok KH (Inventor), Mok KH (Assignee), A pharmaceutical composition comprising a retro-inverso isomer peptide, 2006, Reg European Patent No. 1549334 (27 Sep 2006) Patent, 2006

Goez M, Kuprov I, Mok KH, Hore PJ, Novel pulse sequences for time-resolved photo-CIDNP, Molecular Physics, 104, (10-11), 2006, p1675 - 1686 Journal Article, 2006

Shin C, Mok KH, Han JH, Ahn JH, Lim Y, Conformational analysis in solution of gastrin releasing peptide, Biochemical and Biophysical Research Communications, 350, (1), 2006, p120 - 124 Journal Article, 2006 DOI

Goez, M, Mok KH, Hore PJ, Photo-CIDNP Experiments with an Optimized Presaturation Pulse Train, Gated Continuous Illumination, and a Background-Nulling Pulse Grid, Journal of Magnetic Resonance, 177, (2), 2005, p236 - 246 Journal Article, 2005 DOI

Mok KH (Inventor), Mok KH (Assignee), Improvements to retro-inverso isomers, 2005, Registered UK Patent No. 2389043 (27 July 2005) Patent, 2005

Mok KH, Nagashima T, Day IJ, Hore PJ, Dobson CM, Multiple subsets of side-chain packing in partially folded states of alpha-lactalbumins, Proceedings of the National Academy of Sciences of the USA, 102, (25), 2005, p8899 - 8904 Journal Article, 2005 URL DOI

Mok KH, Hore PJ, Photo-CIDNP NMR methods for studying protein folding (Review), Methods, 34, (1), 2004, p75 - 87 Journal Article, 2004 DOI

Morozova OB, Yurkovskaya AV, Sagdeev RZ, Mok KH, Hore PJ, Time-Resolved CIDNP Study of Native-State Bovine and Human alpha-Lactalbumins, Journal of Physical Chemistry B, 108, (39), 2004, p15355 - 15363 Journal Article, 2004

Koh, D., Yang, H., Kim, K., Lee, S., Mok, K.H., Lim, Y., Stereochemical Elucidation of Norbornene Derivatives Synthesized as Leukotriene D4 Receptor Antagonists, Spectroscopy Letters, 36, (5-6), 2003, p407-418 Journal Article, 2003 DOI

Mok KH, Nagashima T, Day IJ, Jones JA, Jones CJV, Dobson CM, Hore PJ, Rapid Sample-Mixing Technique for Transient NMR and Photo-CIDNP Spectroscopy: Applications to Real-Time Protein Folding, Journal of the American Chemical Society, 125, (41), 2003, p12484 - 12492 Journal Article, 2003

Koh, D., Park, K.H., Jung, J., Yang, H., Hun Mok, K., Lim, Y., Complete assignment of the1H and13C NMR spectra of resveratrol derivatives, Magnetic Resonance in Chemistry, 39, (12), 2001, p768-770 Journal Article, 2001 DOI

Ha S-H, Koh HK, Oh MS, Kim HS, Chung K-T, Lee HS, Mok KH, Cheil Jedang Corporation, Molecular cloning, engineering, and expression of human granulocyte colony stimulating factor (G-CSF), 2000, Registered Republic of Korea Patent No. 0262867 Patent, 2000

Park, J., Chung, I.H., Kim, J.H., Kim, C.S., Mok, K.H., Lim, Y., Structural study of N-(1-benzoyl-3-pyrrolidinyl) benzamide, Spectroscopy Letters, 33, (6), 2000, p777-793 Journal Article, 2000

Lee H, Mok KH, Muhandiram DR, Park K-H, Suk J-E, Kim D-H, Chang J, Sung YC, Choi KW, Han K-H, Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53, Journal of Biological Chemistry, 275, (38), 2000, p29426 - 29432 Journal Article, 2000

Lee HS, Chung J-S, Chung K-T, Mok KH, Kim K-W, Ha S-H, Koh HK, Kim HS, Cheil Jedang Corporation, Homogeneous and Cost-Efficient Purification of Human G-CSF using Preparative Reverse-Phase HPLC, 2000 Patent, 2000

Cho J-H, Mok KH, Olivera BM, McIntosh JM, Park K-H, Han K-H, NMR Solution Conformation of Alpha-Conotoxin AuIB, an Alpha3Beta4 Subtype-Selective Neuronal Nicotinic Acetylcholine Receptor Antagonist, Journal of Biological Chemistry, 275, (12), 2000, p8680 - 8685 Journal Article, 2000

Cho, J.-H., Mok, K.H., Olivera, B.M., McIntosh, J.M., Park, K.-H., Han, K.-H., Nuclear magnetic resonance solution conformation of "-conotoxin AuIB, an "3ß4 subtype-selective neuronal nicotinic acetylcholine receptor antagonist, Journal of Biological Chemistry, 275, (12), 2000, p8680-8685 Journal Article, 2000 DOI

Mok KH, Han K-H, NMR Solution Conformation of an Antitoxic Analog of Alpha-Conotoxin GI: Identification of a Common Nicotinic Accetylcholine Receptor Alpha-1 Subunit Binding Surface for Small Ligands and Alpha-Conotoxins, Biochemistry, 38, (37), 1999, p11895 - 11904 Journal Article, 1999

Mok, K.H., Han, K.-H., NMR solution conformation of an antitoxic analogue of "-conotoxin GI: Identification of a common nicotinic acetylcholine receptor "1-subunit binding surface for small ligands and "-conotoxins, Biochemistry, 38, (37), 1999, p11895-11904 Journal Article, 1999 DOI

Koh HK, Chung K-T, Lee HS, Mok KH, Oh MS, Ahn D-H, Kim C-H, Ha B-J, Lee K-H, Cheil Jedang Corporation, Expression Vector and Producing Strain Containing an Insulin Fusion Protein Gene which Allows Efficient Production of Human Insulin, 1999, Registered Rep of Korea Patent No. 0202958 Patent, 1999