Biography
My lab is interested in understanding the cross-talk between the innate immune system and the metabolic system, and the key molecules involved. A major focus is to understand the cellular metabolic decisions controlling the effector fate of leukocytes that may ultimately open doors to manipulate the immune system in metabolic disorders. This also extends to other situations of altered metabolism, such as in the tumor microenvironment. The goal is to integrate the two aspects of immunometabolism (systemic and intrinsic bioenergetics) to enable us to find metabolic targets for immune cell modulation and ultimately manipulate them in human disease.
Publications and Further Research Outputs
Peer-Reviewed Publications
Kohlgruber A.C, Gal-Oz S.T, LaMarche N.M, Shimazaki M, Duquette D, Koay H.-F, Nguyen H.N, Mina A.I, Paras T, Tavakkoli A, von Andrian U, Uldrich A.P, Godfrey D.I, Banks A.S, Shay T, Brenner M.B, Lynch L, Erratum to: γΎ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis (Nature Immunology, (2018), 19, 5, (464-474), 10.1038/s41590-018-0094-2), Nature Immunology, 20, (3), 2019, p373-
Harmon C, Robinson M.W, Hand F, Almuaili D, Mentor K, Houlihan D.D, Hoti E, Lynch L, Geoghegan J, O'Farrelly C, Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of Liver-Resident NK Cells in Colorectal Liver Metastasis, Cancer immunology research, 7, (2), 2019, p335 - 346
Hong, S. and Song, W. and Zushin, P.-J.H. and Liu, B. and Jedrychowski, M.P. and Mina, A.I. and Deng, Z. and Cabarkapa, D. and Hall, J.A. and Palmer, C.J. and Aliakbarian, H. and Szpyt, J. and Gygi, S.P. and Tavakkoli, A. and Lynch, L. and Perrimon, N. and Banks, A.S., Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes, Molecular Metabolism, 12, 2018, p25-38
Michelet, X. and Dyck, L. and Hogan, A. and Loftus, R.M. and Duquette, D. and Wei, K. and Beyaz, S. and Tavakkoli, A. and Foley, C. and Donnelly, R. and Oâ Farrelly, C. and Raverdeau, M. and Vernon, A. and Pettee, W. and Oâ Shea, D. and Nikolajczyk, B.S. and Mills, K.H.G. and Brenner, M.B. and Finlay, D. and Lynch, L., Metabolic reprogramming of natural killer cells in obesity limits antitumor responses, Nature Immunology, 19, (12), 2018, p1330-1340
Dyck, L. and Lynch, L., New Job for NK Cells: Architects of the Tumor Microenvironment, Immunity, 48, (1), 2018, p9-11
Wu D, Hu D, Chen H, Shi G, Fetahu I.S, Wu F, Rabidou K, Fang R, Tan L, Xu S, Liu H, Argueta C, Zhang L, Mao F, Yan G, Chen J, Dong Z, Lv R, Xu Y, Wang M, Ye Y, Zhang S, Duquette D, Geng S, Yin C, Lian C.G, Murphy G.F, Adler G.K, Garg R, Lynch L, Yang P, Li Y, Lan F, Fan J, Shi Y, Shi Y.G, Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer, Nature, 559, (7715), 2018, p637 - 641
Kohlgruber, A.C. and Gal-Oz, S.T. and Lamarche, N.M. and Shimazaki, M. and Duquette, D. and Nguyen, H.N. and Mina, A.I. and Paras, T. and Tavakkoli, A. and Von Andrian, U. and Banks, A.S. and Shay, T. and Brenner, M.B. and Lynch, L., γΎ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis /631/250/256 /631/250/2504 article, Nature Immunology, 19, (5), 2018, p464-474
LaMarche, N.M. and Lynch, L., Adipose Dendritic Cells Come Out of Hiding, Cell Metabolism, 27, (3), 2018, p485-486
Dyck, L. and Lynch, L., Cancer, obesity and immunometabolism â" Connecting the dots, Cancer Letters, 417, 2018, p11-20
Boulenouar, S. and Michelet, X. and Duquette, D. and Alvarez, D. and Hogan, A.E. and Dold, C. and O'Connor, D. and Stutte, S. and Tavakkoli, A. and Winters, D. and Exley, M.A. and O'Shea, D. and Brenner, M.B. and von Andrian, U. and Lynch, L., Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity, Immunity, 46, (2), 2017, p273-286
Nadine Assmann, Katie L. O'Brien, Raymond P. Donnelly, Lydia Dyck, Vanessa Zaiatz-Bittencourt, Róisín M. Loftus, Paul Heinrich, Peter J. Oefner, Lydia Lynch, Clair M. Gardiner, Katja Dettmer & David K. Finlay, Srebp-controlled glucose metabolism is essential for NK cell functional responses, Nature Immunology, 18, (11), 2017, p1197 - 1206
Chang, S.K. and Kohlgruber, A.C. and Mizoguchi, F. and Michelet, X. and Wolf, B.J. and Wei, K. and Lee, P.Y. and Lynch, L. and Duquette, D. and Ceperuelo-Mallafré, V. and Banks, A.S. and Brenner, M.B., Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes, Journal of Clinical Investigation, 127, (9), 2017, p3300-3312
PrÃŒss, H. and Tedeschi, A. and Thiriot, A. and Lynch, L. and Loughhead, S.M. and Stutte, S. and Mazo, I.B. and Kopp, M.A. and Brommer, B. and Blex, C. and Geurtz, L.-C. and Liebscher, T. and Niedeggen, A. and Dirnagl, U. and Bradke, F. and Volz, M.S. and DeVivo, M.J. and Chen, Y. and Von Andrian, U.H. and Schwab, J.M., Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex, Nature Neuroscience, 20, (11), 2017, p1549-1559
Lynch, L. and Hogan, A.E. and Duquette, D. and Lester, C. and Banks, A. and LeClair, K. and Cohen, D.E. and Ghosh, A. and Lu, B. and Corrigan, M. and Stevanovic, D. and Maratos-Flier, E. and Drucker, D.J. and O'Shea, D. and Brenner, M., iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy, Cell Metabolism, 24, (3), 2016, p510-519
Kohlgruber, A.C. and LaMarche, N.M. and Lynch, L., Adipose tissue at the nexus of systemic and cellular immunometabolism, Seminars in Immunology, 28, (5), 2016, p431-440
Kohlgruber, A. and Lynch, L., Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes, Current Diabetes Reports, 15, (11), 2015
Kim, E.Y. and Lynch, L. and Brennan, P.J. and Cohen, N.R. and Brenner, M.B., The transcriptional programs of iNKT cells, Seminars in Immunology, 27, (1), 2015, p26-32
Carolan E, Tobin L.M, Mangan B.A, Corrigan M, Gaoatswe G, Byrne G, Geoghegan J, Cody D, O'Connell J, Winter D.C, Doherty D.G, Lynch L, O'Shea D, Hogan A.E, Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity, Journal of Immunology, 194, (12), 2015, p5775 - 5780
Lynch, L. and Michelet, X. and Zhang, S. and Brennan, P.J. and Moseman, A. and Lester, C. and Besra, G. and Vomhof-Dekrey, E.E. and Tighe, M. and Koay, H.-F. and Godfrey, D.I. and Leadbetter, E.A. and Sant'Angelo, D.B. and Von Andrian, U. and Brenner, M.B., Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T reg cells and macrophages in adipose tissue, Nature Immunology, 16, (1), 2015, p85-95
Tynan, GA, Hearnden, CH, Oleszycka, E, Lyons, CL, Coutts, G, O'Connell, J, Corrigan, MA, Lynch, L, Campbell, M, Callanan, JJ, Mok, KH, Geoghegan, J, O'Farrelly, C, Allan, SM, Roche, HM, O'Shea, DB, Lavelle, EC, Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1 alpha-Dependent Inflammation, Diabetes, 63, (6), 2014, p2037-2050
Exley, M.A. and Hand, L. and O'Shea, D. and Lynch, L., Interplay between the immune system and adipose tissue in obesity, Journal of Endocrinology, 223, (2), 2014, pR41-R48
Hogan, A.E. and Gaoatswe, G. and Lynch, L. and Corrigan, M.A. and Woods, C. and O'Connell, J. and O'Shea, D., Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus, Diabetologia, 57, (4), 2014, p781-784
Lynch, L., Adipose invariant natural killer T cells, Immunology, 142, (3), 2014, p337-346
Exley, M.A. and Lynch, L. and Nowak, M., NKT cells of cancer patients and how models can inform therapeutic plans, 2012, 129-151pp
Szereday L, Miko E, Meggyes M, Barakonyi A, Farkas B, Varnagy A, Bodis J, Lynch L, O'Farrelly C, Szekeres-Bartho J, Commitment of decidual haematopoietic progenitor cells in first trimester pregnancy., American journal of reproductive immunology (New York, N.Y. : 1989), 67, (1), 2012, p9-16
Lynch L, Nowak M, Varghese B, Clark J, Hogan AE, Toxavidis V, Balk SP, O'Shea D, O'Farrelly C, Exley MA, Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production., Immunity, 37, (3), 2012, p574-87
Tobin, A.M., Lynch, L., Kirby, B., O'Farrelly, C., Natural killer cells in psoriasis, Journal of Innate Immunity , 3, (4), 2011, 403-410
O'Connell, J. and Lynch, L. and Hogan, A. and Cawood, T.J. and O'Shea, D., Preadipocyte factor-1 is associated with metabolic profile in severe obesity, Journal of Clinical Endocrinology and Metabolism, 96, (4), 2011, pE680-E684
Exley, M.A. and Lynch, L. and Varghese, B. and Nowak, M. and Alatrakchi, N. and Balk, S.P., Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: Reversing tumor-induced defects, Clinical Immunology, 140, (2), 2011, p184-195
Hogan AE, Tobin AM, Ahern T, Corrigan MA, Gaoatswe G, Jackson R, O'Reilly V, Lynch L, Doherty DG, Moynagh PN, Kirby B, O'Connell J, O'Shea D, Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis., Diabetologia, 2011
Hogan AE, Corrigan MA, O'Reilly V, Gaoatswe G, O'Connell J, Doherty DG, Lynch L, O'Shea D, Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses., Clinical immunology (Orlando, Fla.), 140, (3), 2011, p229-35
O'Connell, J., Lynch, L., Cawood, T.J., Kwasnik, A., Nolan, N., Geoghegan, J., McCormick, A., (...), O'Shea, D., The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity, PLoS ONE , 5, (4), 2010, part. no. e9997
Nowak, M. and Lynch, L. and Yue, S. and Ohta, A. and Sitkovsky, M. and Balk, S.P. and Exley, M.A., The A2aR adenosine receptor controls cytokine production in iNKT cells, European Journal of Immunology, 40, (3), 2010, p682-687
O'Shea, D., Cawood, T.J., O'Farrelly, C., Lynch, L., Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke., PloS one, 5, (1), 2010, e8660
O'Donovan, A., Hughes, B.M., Slavich, G.M., Lynch, L., Cronin, M.-T., O'Farrelly, C., Malone, K.M, Clinical anxiety, cortisol and interleukin-6: Evidence for specificity in emotion-biology relationships, Brain, Behavior, and Immunity, 24, (7), 2010, p1074-1077
Lynch L, O'Shea D, Winter DC, Geoghegan J, Doherty DG, O'Farrelly C, Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity., European Journal of Immunology, 39, (7), 2009, p1893-1901
Mcgrath, E., Ryan, E.J., Lynch, L., Golden-Mason, L., Mooney, E., Eogan, M., O'herlihy, C., O'Farrelly, C., Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility, American Journal of Reproductive Immunology, 61, (4), 2009, p265-276
Lynch, L.A., O'Connell, J.M., Kwasnik, A.K., Cawood, T.J., O'Farrelly, C., O'Shea, D.B., Are natural killer cells protecting the metabolically healthy obese patient?, Obesity, 17, (3), 2009, p601-605
Lynch, L, Golden-Mason, L, Eogan, M, O';Herlihy, C, O'Farrelly, C, Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility?, Human reproduction (Oxford, England), 22, (4), 2007, p919-26
Lynch, L, O'Donoghue, D, Dean, J, O'Sullivan, J, O'Farrelly, C, Golden-Mason, L, Detection and characterization of hemopoietic stem cells in the adult human small intestine., Journal of immunology (Baltimore, Md. : 1950), 176, (9), 2006, p5199-204