Publications and Further Research Outputs
Peer-Reviewed Publications
Atkins, G.J. and Sheahan, B.J., Molecular determinants of alphavirus neuropathogenesis in mice, Journal of General Virology, 97, (6), 2016, p1283-1296
Roche, F.P., Sheahan, B.J., O'Mara, S.M., Atkins, G.J., Semliki Forest virus-mediated gene therapy of the RG2 rat glioma, Neuropathology and Applied Neurobiology, 36, (7), 2010, p648-660
Piggott, J.M., Sheahan, B.J., Soden, D.M., O'Sullivan, G.C., Atkins, G.J., Electroporation of RNA stimulates immunity to an encoded reporter gene in mice , Molecular Medicine Reports, 2, (5), 2009, p753-756
Atkins GJ, Fleeton MN, Sheahan, BJ. , Therapeutic and prophylactic applications of alphavirus vectors., Expert Reviews in Molecular Medicine., 10, 2008, pe33
Quinn,K, Galbraith, SE, Sheahan, BJ, Atkins, GJ., Effect of intranasal administration of Semliki Forest virus recombinant particles expressing interferon-ß on the progression of experimental autoimmune encephalomyelitis., Molecular Medicine Reports., 1, (3), 2008, p335 - 342
Logue CH, Sheahan BJ, Atkins GJ, The 5' untranslated region as a pathogenicity determinant of Semliki Forest virus in mice., Virus genes, 36, (2), 2008, p313-21
Callagy S.J., Kelly B.J., Fleeton M.N., Sheahan B.J., Galbraith S.E., and Atkins, G. J., Semliki Forest virus vectors expressing the H and HN genes of measles and mumps viruses reduce immunity induced by the envelope protein genes of rubella virus., Vaccine, 25, (43), 2007, p7481 - 7490
Galbraith, S.E., Atkins, G. J., Sheahan, B. J., A Semliki Forest virus replication competent vector with enhanced biosafety., 2007, WO2007/102140
J A Lyons, B J Sheahan, S E Galbraith, R Mehra, G J Atkins and M N Fleeton, Inhibition of angiogenesis by a Semliki Forest virus vector expressing VEGFR-2 reduces tumour growth and metastasis in mice, Gene Therapy, 14, 2007, p503 - 513
Kelly BJ, Fleeton MN, Atkins GJ., Potential of Alphavirus Vectors in the Treatment of Advanced Solid Tumors, Recent patents on anti-cancer drug discovery, 2, 2007, p159-166
Galbraith SE, Sheahan BJ, Atkins GJ, Deletions in the hypervariable domain of the nsP3 gene attenuate Semliki Forest virus virulence, JOURNAL OF GENERAL VIROLOGY, 87, (Part 4), 2006, p937 - 947
Mabruk MJ, Sheahan BJ, Atkins GJ. , The effect of infection of hatched blastocyst bovine embryos with border disease and bovine viral diarrhea viruses, Southeast Asian Journal of Tropical Medicine and Public Health, 37, 2006, p113 - 119
Chikkanna-Gowda CP, McNally S, Sheahan BJ, Fleeton MN, Atkins GJ, Inhibition of murine K-BALB and CT26 tumour growth using a Semliki Forest virus vector with enhanced expression of IL-18, Oncology Reports, 16, 2006, p713 - 719
CP Chikkanna-Gowda, BJ Sheahan, MN Fleeton and GJ Atkins, Regression of mouse tumours and inhibition of metastases following administration of a Semliki Forest virus vector with enhanced expression of IL-12, Gene Therapy, 12, (16), 2005, p1253 - 1263
Greene LM, Fleeton M, Mulligan J, Gowda C, Sheahan BJ, Atkins GJ, Campiani G, Nacci V, Lawler M, Williams DC, Zisterer DM. , The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumour growth in vivo., Oncology Reports, 14, 2005, p1357 - 1363
Greene, L.M., Fleeton, M., Mulligan, J., Chikana, G., Sheahan, B.J., Atkins, G.J., Campiani, G., Nacci, V., Lawler, M., Williams, D.C. and Zisterer, D.M., The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status, and inhibits breast tumour growth in vivo, Oncology Reports, 14, 2005, p1357 - 1363
J.W.P. Smyth, M.N. Fleeton, B.J. Sheahan, G. J. Atkins , Treatment of rapidly growing K-BALB and CT26 mouse tumours using Semliki Forest virus and its derived vector , Gene Therapy, 12, (2), 2005, p147 - 159
G.J. Atkins, M.N. Fleeton, J. W. P. Smyth, B. J. Sheahan, Alphaviruses and their derived vectors as anti-tumor agents, Current Cancer Drug Targets, 4, (7), 2004, p597 - 607
Fleeton MN, Gowda CPC, Atkins GJ, Antiangiogenic tumour therapy using Semliki forest virus vectors encoding IL-12, JOURNAL OF GENE MEDICINE, 6, (9), 2004, pS31 - S31
Keogh, B., Atkins, G.J., Sheahan, B.J. and Mills, K.H.G., Inhibition of metalloproteinases ameliorates blood-brain barrier disruption and neuropathological lesions caused by avirulent semliki forest virus infection, Vet. Immunol. Immunopathol., 94, (3-4), 2003, p185 - 190
Atkins, G. J. and Cosby, S. L, Is an improved measles-mumps-rubella vaccine necessary or feasible?, Critical Reviews in Immunology , 23, (4), 2003, p323 - 338
Jerusalmi, A., Morris-Downes, M. M., Sheahan, B. J. and Atkins, G. J., Effect of intranasal administration of Semliki Forest virus recombinant particles expressing reporter and cytokine genes on the progression of experimental autoimmune encephalomyelitis., Molecular Therapy, 8, (6), 2003, p886 - 894
Keogh, B., Atkins, G.J., Mills, K.H.G. and Sheahan, B.J., Role of interferon-gamma and nitric oxide in the neuropathogenesis of avirulent semliki forest virus infection Neuropathol, Neuropathology and Applied Neurobiology , 29, (6), 2003, p553 - 562
Keogh, B., Sheahan, B. J., Atkins, G. J. and Mills, K. H. G., Inhibition of matrix metalloproteinases ameliorates blood-brain barrier disruption and neuropathological lesions caused by avirulent Semliki Forest virus infection., Veterinary Immunology and Immunopathology, 94, (3-4), 2003, p185 - 190
Keogh, B., Atkins, G. J., Mills, K. H. G. and Sheahan, B. J., Role of interferon- × and nitric oxide in the neuropathogenesis of avirulent Semliki Forest virus infection, Neuropathology and Applied Neurobiology , 29, (6), 2003, p553 - 562
Atkins, G. J., Mooris-Downes, M. M., Jerusalmi, A. and Sheahan, B. J. , An expression vector for the central nervous system, 2003, PCT/IE03/00089
KEOGH, B, AVIRULENT SEMLIKI FOREST VIRUS REPLICATION AND PATHOLOGY IN THE CENTRAL NERVOUS SYSTEM IS ENHANCED IN IL-12-DEFECTIVE AND REDUCED IN IL-4-DEFECTIVE MICE: A ROLE FOR TH1 CELLS IN THE PROTECTIVE IMMUNITY, JOURNAL OF NEUROIMMUNOLOGY, 125, 2002, p15 - 22
Keogh, B., Atkins, G.J., Mills, K.H.G., Sheahan, B.J, Avirulent Semliki Forest virus replication and pathology in the central nervous system is enhanced in IL-12-defective and reduced in IL-4-defective mice: A role for Th1 cells in the protective immunity , Journal of Neuroimmunology , 125, 2002, p15 - 22
DOMEGAN, LM, ATKINS, GJ., APOPTOSIS INDUCTION BY THE THERIEN AND VACCINE RA27/3 STRAINS OF RUBELLA VIRUS CAUSES DEPLETION OF OLIGODENDROCYTES FROM RAT NEURAL CELL CULTURES, JOURNAL OF GENERAL VIROLOGY, 83, 2002, p2135 - 2143
Sheahan, B.J., Moore, M., Atkins, G.J., The pathogenicity of louping Ill virus for mice and lambs , Journal of Comparative Pathology , 126, 2002, p137 - 146
Atkins, G. J., 5th Gene Delivery & Cellular Protein Expression Conference, Vienna, 2001
O'Connor, D. P., Kay, E. W., Leader, M., Murphy, G. M., Atkins, G. J. & Mabruk, M. J. E. M. F., A high degree of chromosomal instability at 13q14 in cutaneous squamous cell carcinomas: indication for a role of a tumour, Molecular Pathology , 54, 2001, p165 - 169
MURPHY, AM, INDUCTION OF APOPTOSIS IN BCL-2-EXPRESSING RAT PROSTATE CANCER CELLS USING THE SEMLIKI FOREST VIRUS VECTOR, INTERNATIONAL JOURNAL OF CANCER, 94, 2001, p572 - 578
OCONNOR, DP, ALTERED P53 EXPRESSION IN BENIGN AND MALIGNANT SKIN LESIONS FROM RENAL TRANSPLANT RECIPIENTS AND IMMUNOCOMPETENT PATIENTS WITH SKIN CANCER: CORRELATION WITH HUMAN PAPILLOMAVIRUSES?, DIAGNOSTIC MOLECULAR PATHOLOGY, 10, 2001, p190 - 199
MORRIS-DOWNES, MM, SEMLIKI FOREST VIRUS-BASED VACCINES: PERSISTENCE, DISTRIBUTION AND PATHOLOGICAL ANALYSIS IN TWO ANIMAL SYSTEMS, VACCINE, 19, 2001, p1978 - 1988
OCONNOR, DP, A HIGH DEGREE OF CHROMOSOMAL INSTABILITY AT 13Q14 IN CUTANEOUS SQUAMOUS CELL CARCINOMAS: INDICATION FOR A ROLE OF A TUMOUR SUPPRESSOR GENE OTHER THAN RB, JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY, 54, 2001, p165 - 169
Atkins, G. J., European Committee for Research and Treatment in Multiple Sclerosis 17th symposium , 2001
FLEETON, MN, SELF-REPLICATIVE RNA VACCINES ELICIT PROTECTION AGAINST INFLUENZA A VIRUS, RESPIRATORY SYNCYTIAL VIRUS, AND A TICKBORNE ENCEPHALITIS VIRUS, JOURNAL OF INFECTIOUS DISEASES, 183, 2001, p1395 - 1398
OCONNOR, DP, P53 CODON 72 POLYMORPHISM AND HUMAN PAPILLOMAVIRUS ASSOCIATED SKIN CANCER, JOURNAL OF CLINICAL PATHOLOGY, 54, 2001, p539 - 542
MORRIS-DOWNES, MM, A RECOMBINANT SEMLIKI FOREST VIRUS PARTICLE VACCINE ENCODING THE PRME AND NSL PROTEINS OF LOUPING ILL VIRUS IS EFFECTIVE IN A SHEEP CHALLENGE MODEL, VACCINE, 19, 2001, p3877 - 3884
MCKENNA, BM, FORMATION OF INFECTIOUS PANCREATIC NECROSIS VIRUS-LIKE PARTICLES FOLLOWING EXPRESSION OF SEGMENT A BY RECOMBINANT SEMLIKI FOREST VIRUS, MARINE BIOTECHNOLOGY, 3, 2001, p103 - 110
MABRUK, MJEMF, A SIMPLE AND RAPID TECHNIQUE FOR THE DETECTION OF EPSTEIN-BARR VIRUS DNA IN HIV-ASSOCIATED ORAL HAIRY LEUKOPLAKIA BIOPSIES, JOURNAL OF ORAL PATHOLOGY & MEDICINE, 29, 2000, p118 - 122
MURPHY, AM, INHIBITION OF HUMAN LUNG CARCINOMA CELL GROWTH BY APOPTOSIS INDUCTION USING SEMLIKI FOREST VIRUS RECOMBINANT PARTICLES, GENE THERAPY, 7, 2000, p1477 - 1482
FLEETON, MN, RECOMBINANT SEMLIKI FOREST VIRUS PARTICLES EXPRESSING LOUPING ILL VIRUS ANTIGENS INDUCE A BETTER PROTECTIVE RESPONSE THAN PLASMID-BASED DNA VACCINES OR AN INACTIVATED WHOLE PARTICLE VACCINE, JOURNAL OF GENERAL VIROLOGY, 81, 2000, p749 - 758
Atkins, G. J., Mc Quaid, S., Morris-Downes, M. M., Galbraith, S. E., Amor, S., Cosby, S. L. and Sheahan, B. J. , TRANSIENT VIRUS INFECTION AND MULTIPLE SCLEROSIS, REVIEWS IN MEDICAL VIROLOGY, 10, 2000, p291-303
Phenix, K. V., McKenna, B., Fitzpatrick, R., Vaughan, L., Atkins, G., Liljeström, P. & Todd, D., Cell culture evaluation of the Semliki Forest virus expression system as a novel approach for antigen delivery and expression in fish, Marine Biotechnology , 2, 2000, p27 - 37
Atkins, G. J., Techniques for gene manipulation, targeting and delivery in the nervous system , EU/FEBS course: , 2000
SAMMIN, DJ, CELL DEATH MECHANISMS IN THE OLFACTORY BULB OF RATS INFECTED INTRANASALLY WITH SEMLIKI FOREST VIRUS, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 25, 1999, p236 - 243
FLEETON, MN, RECOMBINANT SEMLIKI FOREST VIRUS PARTICLES ENCODING THE PRME OR NS1 PROTEINS OF LOUPING ILL VIRUS PROTECT MICE FROM LETHAL CHALLENGE, JOURNAL OF GENERAL VIROLOGY, 80, 1999, p1189 - 1198
Atkins, G. J. , Sheahan, B. J. and Liljeström, P., The molecular pathogenesis of Semliki Forest virus: a model virus made useful?, Journal of General Virology, 80, 1999, p2287-2297
Atkins, G. J., Society for General Microbiology symposium, 1998
Molecular approaches to fish vaccine design in, editor(s)A. Barnes, G. Davidson, M. Hiney and D. McIntosh , Methodology in Fish Disease Research, Aberdeen, Scotland., Albion Press, 1998, pp161 - 166, [Vaughan, L.M., Fitzpatrick, R.M., McKenna B. and Atkins, G. J. ]
Vaccination with recombinant suicidal DNA/RNA in, editor(s)O. Merten, P. Perrin & B. Griffithspp , New Developments and New Applications in Animal Cell Technology, Dordrecht., Kluwer Academic Publishers, 1998, pp583 - 590, [Berglund, P., Fleeton, M., Smerdou, C., Tubulekas, I., Sheahan, B. J., Atkins, G. J. & Liljeström, P]
GLASGOW, GM, THE SEMLIKI FOREST VIRUS VECTOR INDUCES P53-INDEPENDENT APOPTOSIS, JOURNAL OF GENERAL VIROLOGY, 79, 1998, p2405 - 2410
GLASGOW, GM, DEATH MECHANISMS IN CULTURED CELLS INFECTED BY SEMLIKI FOREST VIRUS, JOURNAL OF GENERAL VIROLOGY, 78, 1997, p1559 - 1563
SAMMIN, DJ, SHEAHAN, BJ, ATKINS, GJ, MECHANISMS OF CELL DEATH IN THE CNS OF WEANLING RATS INFECTED WITH SEMLIKI FOREST VIRUS, IRISH VETERINARY JOURNAL, 50, 1997, p365 - 365
TARBATT, CJ, SEQUENCE ANALYSIS OF THE AVIRULENT, DEMYELINATING A7 STRAIN OF SEMLIKI FOREST VIRUS, JOURNAL OF GENERAL VIROLOGY, 78, 1997, p1551 - 1557
Caffrey, J. F., Dudgeon, A. M., Donnelly, W. J. C., Atkins, G. J. and Sheahan, B. J. , Morphometric analysis of growth retardation in foetal lambs following experimental infection of pregnant ewes with border disease virus, Research in Veterinary Science , 62, 1997, p245 - 248
DONNELLY, SM, LONG-TERM EFFECTS OF SEMLIKI FOREST VIRUS INFECTION IN THE MOUSE CENTRAL NERVOUS SYSTEM, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 23, 1997, p235 - 241
MABRUK, MJEMF, A RAPID MICROWAVE-IN SITU HYBRIDIZATION METHOD FOR THE DEFINITIVE DIAGNOSIS OF ORAL HAIRY LEUKOPLAKIA: COMPARISON WITH IMMUNOHISTOCHEMISTRY, JOURNAL OF ORAL PATHOLOGY & MEDICINE, 25, 1996, p170 - 176
BALLUZ, IM, FARRELL, MA, KAY, E, STAUNTON, MJ, KEATING, JN, SHEILS, O, COSBY, SL, MABRUK, MJEMF, SHEAHAN, BJ, ATKINS, GJ, COLOCALISATION OF HUMAN IMMUNODEFICIENCY VIRUS AND HUMAN CYTOMEGALOVIRUS INFECTION IN BRAIN AUTOPSY TISSUE FROM AIDS PATIENTS, IRISH JOURNAL OF MEDICAL SCIENCE, 165, 1996, p133 - 138
Sheahan, B. J., Ibrahim, M. A., and Atkins, G. J. , Demyelination of olfactory pathways in mice following intranasal infection with the avirulent A7 strain of Semliki Forest virus., European Journal of Veterinary Pathology , 2, 1996, p117 - 125
ATKINS, GJ, SHEAHAN, BJ, LILJESTROM, P, MANIPULATION OF THE SEMLIKI FOREST VIRUS GENOME AND ITS POTENTIAL FOR VACCINE CONSTRUCTION, MOLECULAR BIOTECHNOLOGY, 5, 1996, p33 - 38
Mabruk, M. J. E. M. F., Flint, S. R., Coleman, D. C., Toner, M. and Atkins, G. J. , Diagnosis and treatment of oral hairy leukoplakia, of the European Academy of Dermatology and Venereology, 6, 1996, p127 - 134
Mabruk MJ, Flint SR, Coleman DC, Shiels O, Toner M, Atkins GJ., A rapid microwave-in situ hybridization method for the definitive diagnosis of oral hairy leukoplakia: comparison with immunohistochemistry., Journal of Oral Pathology & Medicine, 25, (4), 1996, p170-176
ATKINS, GJ, MABRUK, MJEMF, GLASGOW, GM, GRIFFIN, AM, SHEAHAN, BJ, MECHANISMS OF VIRAL TERATOGENESIS, REVIEWS IN MEDICAL VIROLOGY, 5, 1995, p75 - 86
Mabruk MJ, Flint SR, Toner M, Leonard N, Sheils O, Coleman DC, Atkins GJ., Detection of Epstein-Barr virus DNA in tongue tissues from AIDS autopsies without clinical evidence of oral hairy leukoplakia., Journal of Oral Pathology and Medicine, 24, (3), 1995, p109-112
MABRUK, MJEMF, DETECTION OF EPSTEIN-BARR-VIRUS DNA IN TONGUE TISSUES FROM AIDS AUTOPSIES WITHOUT CLINICAL-EVIDENCE OF ORAL HAIRY LEUKOPLAKIA, JOURNAL OF ORAL PATHOLOGY & MEDICINE, 24, 1995, p109 - 112
ATKINS, GJ, BALLUZ, IM, GLASGOW, GM, MABRUK, MJEMF, NATALE, VAI, SMYTH, JMB, SHEAHAN, BJ, ANALYSIS OF THE MOLECULAR-BASIS OF NEUROPATHOGENESIS OF RNA VIRUSES IN EXPERIMENTAL-ANIMALS - RELEVANCE FOR HUMAN-DISEASE, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 20, 1994, p91 - 102
Frey, T., Mitchell, L. A., Best, J. M., Schalasta, G., Katow, S., Wolinsky, J. S., Gillam, S., Atkins, G. J., Chantler, J. & Nakhasi, H. L., of an international meeting on rubella vaccines and vaccination, 9 August 1993, Glasgow, United Kingdom, Journal of Infectious Diseases , 170, 1994, p507 - 509
GLASGOW, GM, A SINGLE AMINO-ACID CHANGE IN THE E2 SPIKE PROTEIN OF A VIRULENT-STRAIN OF SEMLIKI-FOREST VIRUS ATTENUATES PATHOGENICITY, JOURNAL OF GENERAL VIROLOGY, 75, 1994, p663 - 668
Atkins, G. J., Society for General Microbiology symposium, 1994
MABRUK, MJEMF, IN-SITU HYBRIDIZATION AND THE POLYMERASE CHAIN-REACTION (PCR) IN THE ANALYSIS OF BIOPSIES AND EXFOLIATIVE CYTOLOGY SPECIMENS FOR DEFINITIVE DIAGNOSIS OF ORAL HAIRY LEUKOPLAKIA (OHL), JOURNAL OF ORAL PATHOLOGY & MEDICINE, 23, 1994, p302 - 308
BALLUZ, IM, GLASGOW, GM, KILLEN, HM, MABRUK, MJMEF, SHEAHAN, BJ, ATKINS, GJ, VIRULENT AND AVIRULENT STRAINS OF SEMLIKI FOREST VIRUS SHOW SIMILAR CELL TROPISM FOR THE MURINE CENTRAL-NERVOUS-SYSTEM BUT DIFFER IN THE SEVERITY AND RATE OF INDUCTION OF CYTOLYTIC DAMAGE, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 19, 1993, p233 - 239
Natale, V. A. I., Sheahan, B. J. & Atkins, G. J. , EFFECT OF INFECTION WITH RUBELLA-VIRUS ON THE DEVELOPMENT OF RAT CEREBELLAR CELLS IN CULTURE. Neuropathology and Applied Neurobiology 19, 530-534., 1993, -
BERGLUND, P, SEMLIKI FOREST VIRUS EXPRESSION SYSTEM - PRODUCTION OF CONDITIONALLY INFECTIOUS RECOMBINANT PARTICLES, BIO-TECHNOLOGY, 11, 1993, p916 - 920
Atkins, G. J., Society for General Microbiology symposium, 1992
GLASGOW, GM, SHEAHAN, BJ, ATKINS, GJ, WAHLBERG, JM, SALMINEN, A, LILJESTROM, P, 2 MUTATIONS IN THE ENVELOPE GLYCOPROTEIN-E2 OF SEMLIKI FOREST VIRUS AFFECTING THE MATURATION AND ENTRY PATTERNS OF THE VIRUS ALTER PATHOGENICITY FOR MICE, VIROLOGY, 185, 1991, p741 - 748
ATKINS, GJ, MOONEY, DA, FAHY, DA, NG, SH, SHEAHAN, BJ, MULTIPLICATION OF RUBELLA AND MEASLES VIRUSES IN PRIMARY RAT NEURAL CELL-CULTURES - RELEVANCE TO A POSTULATED TRIGGERING MECHANISM FOR MULTIPLE-SCLEROSIS, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 17, 1991, p299 - 308
Atkins, G. J., American Society for Virology symposium, 1991
Atkins, G. J., International Conference of Multiple Sclerosis Societies symposium, 1990
ATKINS, GJ, SHEAHAN, BJ, MOONEY, DA, PATHOGENICITY OF SEMLIKI FOREST VIRUS FOR THE RAT CENTRAL-NERVOUS-SYSTEM AND PRIMARY RAT NEURAL CELL-CULTURES - POSSIBLE IMPLICATIONS FOR THE PATHOGENESIS OF MULTIPLE-SCLEROSIS, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 16, 1990, p57 - 68
Atkins, G. J., Daly, E. A., Sheahan, B. J., Higgins, D. G. & Sharp, P. M. , Multiple sclerosis and molecular mimicry., Neuropathology and Applied Neurobiology , 16, 1990, p179 - 180
SMYTH, JMB, MULTIPLICATION OF VIRULENT AND DEMYELINATING SEMLIKI FOREST VIRUS IN THE MOUSE CENTRAL-NERVOUS-SYSTEM - CONSEQUENCES IN BALB/C AND SJL MICE, JOURNAL OF GENERAL VIROLOGY, 71, 1990, p2575 - 2583
MABRUK, MJEMF, GLASGOW, GM, FLACK, AM, FOLAN, JC, BANNIGAN, JG, SMYTH, JMB, OSULLIVAN, MA, SHEAHAN, BJ, ATKINS, GJ, EFFECT OF INFECTION WITH THE TS22 MUTANT OF SEMLIKI FOREST VIRUS ON DEVELOPMENT OF THE CENTRAL NERVOUS-SYSTEM IN THE FETAL MOUSE, JOURNAL OF VIROLOGY, 63, 1989, p4027 - 4033
MABRUK, MJEMF, TERATOGENICITY OF THE SEMLIKI FOREST VIRUS MUTANT TS22 FOR THE FETAL MOUSE - INDUCTION OF SKELETAL AND SKIN DEFECTS, JOURNAL OF GENERAL VIROLOGY, 69, 1988, p2755 - 2762
HEARNE, AM, ISOLATION AND PRELIMINARY CHARACTERIZATION OF SEMLIKI FOREST VIRUS MUTANTS WITH ALTERED PATHOGENICITY FOR MOUSE EMBRYOS, JOURNAL OF GENERAL VIROLOGY, 68, 1987, p107 - 113
HEARNE, AM, INFECTION OF CULTURED EARLY MOUSE EMBRYOS WITH SEMLIKI FOREST AND RUBELLA VIRUSES, JOURNAL OF GENERAL VIROLOGY, 67, 1986, p1091 - 1098
GATES, MC, THE PATHOGENICITY OF THE A7-STRAIN, M9-STRAIN AND L10-STRAIN OF SEMLIKI FOREST VIRUS FOR WEANLING MICE AND PRIMARY MOUSE-BRAIN CELL-CULTURES, JOURNAL OF GENERAL VIROLOGY, 66, 1985, p2365 - 2373
Gates, M. C., Sheahan, B. J., O'Sullivan, M. A. & Atkins, G. J., The pathogenicity of the A7, M9 and L10 strains of Semliki Forest virus for weanling mice and primary mouse brain cell cultures., Journal of General Virology , 66, 1985, p2365 - 2373
Atkins, G, J,, Sheahan, B. J., Dimmock, N. J., , SEMLIKI FOREST VIRUS-INFECTION OF MICE - A MODEL FOR GENETIC AND MOLECULAR ANALYSIS OF VIRAL PATHOGENICITY, JOURNAL OF GENERAL VIROLOGY, 66, 1985, p395-408
GATES, MC, THE PATHOGENICITY OF THE M9 MUTANT OF SEMLIKI FOREST VIRUS IN IMMUNE-COMPROMISED MICE, JOURNAL OF GENERAL VIROLOGY, 65, 1984, p73 - 80
Atkins, G. J., Multiple sclerosis - is a virus involved? , Viral Therapeutics , 3, 1983, p1 - 2
SHEAHAN, BJ, GATES, MC, CAFFREY, JF, ATKINS, GJ, OLIGODENDROCYTE INFECTION AND DEMYELINATION PRODUCED IN MICE BY THE M9-MUTANT OF SEMLIKI FOREST VIRUS, ACTA NEUROPATHOLOGICA, 60, 1983, p257 - 265
GLASGOW, G, ATKINS, G.J., EFFECT OF PERSISTENT INFECTION ON THE GROWTH OF TUMOR-CELLS IN MICE, Irish Jurnal of Medical Science, 1983, 152, 1983, pp253 - 253
ATKINS, GJ, THE AVIRULENT-A7 STRAIN OF SEMLIKI FOREST VIRUS HAS REDUCED CYTOPATHOGENICITY FOR NEURO-BLASTOMA CELLS COMPARED TO THE VIRULENT-L10 STRAIN, JOURNAL OF GENERAL VIROLOGY, 64, 1983, p1401 - 1404
Atkins, G. J., Virus persistence in the central nervous system, Viral Therapeutics , 4, 1983, p6 - 7
ATKINS, GJ, SHEAHAN, BJ, SEMLIKE FOREST VIRUS NEUROVIRULENCE MUTANTS HAVE ALTERED CYTOPATHOGENICITY FOR CENTRAL NERVOUS-SYSTEM CELLS, INFECTION AND IMMUNITY, 36, 1982, p333 - 341
ATKINS, GJ, CARTER, J, SHEAHAN, BJ, EFFECT OF ALPHAVIRUS INFECTION ON MOUSE EMBRYOS, INFECTION AND IMMUNITY, 38, 1982, p1285 - 1290
BARRETT, PN, ESTABLISHMENT OF PERSISTENT INFECTION IN MOUSE CELLS BY SINDBIS VIRUS AND ITS TEMPERATURE-SENSITIVE MUTANTS, JOURNAL OF GENERAL VIROLOGY, 54, 1981, p57 - 65
SHEAHAN, BJ, BARRETT, PN, ATKINS, GJ, DEMYELINATION IN MICE RESULTING FROM INFECTION WITH A MUTANT OF SEMLIKI FOREST VIRUS, ACTA NEUROPATHOLOGICA, 53, 1981, p129 - 136
Sheahan, B. J., Atkins, G. J., Russell, R. J. & O'Connor, J. P., Observations on two cases of histiolymphocytic lymphosarcoma in the subcutis of the horse, Veterinary Pathology , 17, 1980, p123 - 133
Barrett, P. N., Sheahan, B. J. & Atkins, G. J. , Isolation and preliminary characterization of mutants of Semliki Forest virus with altered virulence, Journal of General Virology , 49, 1980, p141 - 148
Barrett, P. N. & Atkins, G. J., Virulence of temperature-sensitive mutants of Sindbis virus in neonatal mice. , Infection and Immunity , 26, 1979, p848 - 852
Atkins, G. J., Establishment of persistent infection in BHK-21 cells by temperature-sensitive mutants of Sindbis virus, Journal of General Virology , 45, 1979, p201 - 207
Brezeski, H., Clegg, J. C. S., Atkins, G. J. & Kennedy, S. I. T., Regulation of the synthesis of Sindbis virus-specified RNA: role of the virion core protein, Journal of General Virology , 38, 1978, p461 - 470
Atkins, G. J, Cytopathogenicity of temperature-sensitive mutants of Sindbis virus, FEMS Microbiology Letters , 2, 1977, p51 - 55
Atkins, G. J., Moynihan, M., Arbuthnott, E. & Hartigan, P. J., Detection of C-type virus in immunologically reactive ovine lymph nodes, FEMS Microbiology Letters , 2, 1977, p75 - 77
Atkins, G. J. & Lancashire, C. L., Interferon induction by temperature-sensitive mutants of Sindbis virus: its relationship to virus-specified double-stranded RNA synthesis and cytopathic effect, Journal of General Virology , 30, 1976, p157 - 165
Atkins, G. J., The effect of infection with Sindbis virus and its temperature-sensitive mutants on cellular protein and DNA synthesis, Virology, 71, 1976, p593 - 597
Atkins, G. J. & Avery, R. J, DNA homology, redundancy and genome size of four Rhizobium bacteriophages., Journal of General Virology , 24, 1974, p301 - 306
Atkins, G. J., Johnstone, M. D., Westmacott, L. & Burke, D. C, Induction of interferon in chick cells by temperature-sensitive mutants of Sindbis virus, Journal of General Virology, 25, 1974, p381 - 390
Atkins, G. J., Samuels, J. & Kennedy, S. I. T, Isolation and preliminary characterization of temperature-sensitive mutants of Sindbis virus strain AR339, Journal of General Virology , 25, 1974, p371 - 380
Atkins, G. J., Some bacteriophages active against Rhizobium trifolii strain W19., Journal of Virology , 12, 1973, p149 - 156
Atkins, G. J. , Isolation and preliminary characterization of temperature-sensitive mutants of rhizobiophage c, Journal of Virology , 12, 1973, p157 - 164
Atkins, G. J. & Hayes, A. E. , Surface changes in a strain of Rhizobium trifolii on mutation to bacteriophage resistance , Journal of General Microbiology , 73, 1972, p273 - 278
Non-Peer-Reviewed Publications
Atkins, G. J., SGM workshop on Viral Vectors, 2003, Edinburgh
Semliki Forest Virus (L10) Complete Genome, Genbank, AY112987, 2002, [Logue,C., Mooney,D., Shanley,R. and Atkins,G.J.]
Chikungunya Virus (Ross) Complete Genome, Genbank, AF490259, 2002, [Logue CH, Atkins GJ]
Research Expertise
Description
Current research interests 1.Analysis of the molecular basis of alphavirus pathogenicity: We have suggested mechanisms of teratogenesis and neurovirulence of Semliki Forest virus at the cellular level and our current work is aimed at determination of the molecular control of pathogenesis. In this work we utilise infectious clones of SFV. By using chimeric virus construction and site-directed mutagenesis, we have shown that several mutations and sequences can influence viral pathogenesis. Current work involves analysis of the mechanisms of virus-induced death in neural cells and the involvement of virus proteins in this process. 2. Analysis of the mechanism of virus-induced demyelination and its relevance to multiple sclerosis: Present work is aimed at elucidating the role of cytokines, virus persistence and apoptosis in the process of demyelination. This work has been extended to include human rubella virus (a togavirus like SFV), and we have shown that rubella virus has similar tropism in neural cell culture to SFV. 3. Use of Semliki Forest virus as a vector in the construction of viral vaccines ,as a tumour therapy agent and as a CNS vector: Virus vaccines in current use have many disadvantages and in rare cases can cause disease. We are using a vector system, developed by workers at the Karolinska Institute in Stockholm with our help, to construct new virus vaccines. This is a collaborative project with the Karolinska Institute and the Department of Veterinary Pathology at UCD, and part of our work is concerned with improvement of the biosafety of the system. This work has recently been extended to the use of SFV as a cytotoxic cancer therapy agent, and to the development of SFV as a vector for the central nervous system. New virus vectors are currently being constructed and patented.Projects
- Title
- Construction and development of a new prototype measles-mumps-rubella vaccine based on recombinant RNA
- Summary
- 766846
- Funding Agency
- Science Foundation Ireland
- Date From
- 2004
- Date To
- 2008
- Title
- Construction and development of novel and improved Semliki Forest virus vectors for RNA-based transient gene therapy
- Summary
- 156321
- Funding Agency
- Science Foudation Ireland
- Date From
- 2005
- Date To
- 2008
- Title
- Therapy for MS
- Summary
- 25125
- Funding Agency
- Multiple Sclerosis Society of Ireland
- Date From
- 2005
- Date To
- 2008
- Title
- Treatment of glioma using an RNA gene therapy vector
- Summary
- 160000
- Funding Agency
- Science Foundation Ireland
- Date From
- 2005
- Date To
- 2009
- Title
- Development of a replication competent RNA vector for the treatment of advanced solid tumours
- Summary
- 243473
- Funding Agency
- Enterprise Ireland
- Date From
- 2006
- Date To
- 2009
Recognition
Representations
Committee, Society for General Microbiology, Irish Branch
Evaluation panel, Enterprise Ireland Basic Science Programme
EU evaluation panel, Biotechnology Programme
Member, WHO working group on Biosafety of Nucleic Acid Vaccines
First and second stage evaluation panels, EU 5th Framework Programme
Research Committee, Multiple Sclerosis Society of Ireland
Health Research Board Committees: Mechanisms of Disease and North-South Collaboration
GMO Advisory Committee, Environmental Protection Agency
Interview panel, HRB Research Fellowships
Consultant for Environmental Protection Agency (industrial use of viral vectors)
Consultant for Alexander Harris, UK solicitors for vaccine-damaged children (also advisor to barristers involved in MMR litigation).
Awards and Honours
UICC Fellow, Karolinska Institute, Stockholm, Sweden
EMBO Fellow, University of Helsinki, Finland
Fogarty International Fellow, Washington University, St. Louis, USA
Fellow, Trinity College Dublin
Memberships
British Society for Gene Therapy (founder member)
European Society for Gene Therapy
International Society for Neurovirology (founder member).
American Society for Microbiology
Society for General Microbiology