Dr. Clair Gardiner
Professor, Biochemistry
Publications and Further Research Outputs
Peer-Reviewed Publications
Woods E, Mena A, Sierpinska S, Carr E, STTAR Bioresource, Hagan R, Crowley J, Bergin C, Clark D, Brophy C, Macallan D, Gardiner CM., Reduced IFNL1 and/or IFNL2, but not IFNL3 is associated with worse outcome in patients with COVID-19., Clinical and experimental immunology, 2024, puxae047
Slattery K., Breheny M., Woods E., Keating S., Brennan K., Rooney C., Augustine S., Ryan A., Owens C., Gardiner C.M., Heightened metabolic responses in NK cells from patients with neuroblastoma suggests increased potential for immunotherapy, Frontiers in Oncology, 12, 2022
Nidhi Kedia-Mehta, Laura Tobin, Vanessa Zaiatz-Bittencourt, Marta M Pisarska, Conor De Barra, Chloe Choi, Einas Elamin, Donal O'Shea , Clair M Gardiner, David K Finlay, Andrew E Hogan , Cytokine-induced natural killer cell training is dependent on cellular metabolism and is defective in obesity, Blood Advances, 5, (21), 2021, p4447-4455
O'Brien, K.L. and Assmann, N. and O'Connor, E. and Keane, C. and Walls, J. and Choi, C. and Oefner, P.J. and Gardiner, C.M. and Dettmer, K. and Finlay, D.K., De novo polyamine synthesis supports metabolic and functional responses in activated murine NK cells, European Journal of Immunology, 51, (1), 2021, p91-102
Slattery K., Woods E., Zaiatz-Bittencourt V., Marks S., Chew S., Conroy M., Goggin C., Maceochagain C., Kennedy J., Lucas S., Finlay D.K., Gardiner C.M., TGFß drives NK cell metabolic dysfunction in human metastatic breast cancer, Journal for ImmunoTherapy of Cancer, 9, (2), 2021
Jessica F. Walls, Jeff J. Subleski, Erika M. Palmieri, Marieli Gonzalez Cotto, Clair M. Gardiner, Daniel W. McVicar, David K. Finlay, Metabolic but not transcriptional regulation by PKM2 is important for Natural Killer cell responses, eLIFE, 2020
Hartnell, F. and Brown, A. and Capone, S. and Kopycinski, J. and Bliss, C. and Makvandi-Nejad, S. and Swadling, L. and Ghaffari, E. and Cicconi, P. and Sorbo, M.D. and Sbrocchi, R. and Esposito, I. and Vassilev, V. and Marriott, P. and Gardiner, C.M. and Bannan, C. and Bergin, C. and Hoffmann, M. and Turner, B. and Nicosia, A. and Folgori, A. and Hanke, T. and Barnes, E. and Dorrell, L., A novel vaccine strategy employing serologically different chimpanzee adenoviral vectors for the prevention of HIV-1 and HCV coinfection, Frontiers in Immunology, 10, (JAN), 2019
Slattery, K. and Gardiner, C.M., NK Cell Metabolism and TGFβ â" Implications for Immunotherapy, Frontiers in Immunology, 10, (2915), 2019
Gardiner, C.M., How to wake a killer, Nature Immunology, 20, (12), 2019, p1561-1563
Cluxton, C.D. and Spillane, C. and Oâ Toole, S.A. and Sheils, O. and Gardiner, C.M. and Oâ Leary, J.J., Suppression of Natural Killer cell NKG2D and CD226 anti-tumour cascades by platelet cloaked cancer cells: Implications for the metastatic cascade, PLoS ONE, 14, (3), 2019
Gardiner, C.M., NK cell metabolism, Journal of Leukocyte Biology, 105, (6), 2019, p1235-1242
Loftus, R.M. and Assmann, N. and Kedia-Mehta, N. and O'Brien, K.L. and Garcia, A. and Gillespie, C. and Hukelmann, J.L. and Oefner, P.J. and Lamond, A.I. and Gardiner, C.M. and Dettmer, K. and Cantrell, D.A. and Sinclair, L.V. and Finlay, D.K., Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice, Nature Communications, 9, (1), 2018
Zaiatz-Bittencourt, D.K. Finlay, C.M. Gardiner., Canonical TGF signalling pathway represses human NK cell metabolism, Journal of Immunology, 200, (12), 2018, p3934 - 3941
Clair M. Gardiner and David K. Finlay, What Fuels Natural Killers? Metabolism and NK Cell Responses, Frontiers in Immunolobgy, 8, 2017
Brennan K, McSharry BP, Keating S, Petrasca A, O'Reilly VP, Keane J, Doherty DG, Gardiner CM, Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype., Human immunology, 77, (10), 2016, p876-885
Deac OM, Mills JL, Gardiner CM, Shane B, Quinn L, Midttun O, McCann A, Meyer K, Ueland PM, Fan R, Lu Z, Brody LC, Molloy AM, Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults, J Nutr, 146, (9), 2016, p1801 - 1806
Fischer J, Weber AN, Böhm S, Dickhöfer S, El Maadidi S, Deichsel D, Knop V, Klinker H, Möller B, Rasenack J, Wang L, Sharma M, Hinrichsen H, Spengler U, Buggisch P, Sarrazin C, Pawlita M, Waterboer T, Wiese M, Probst-Müller E, Malinverni R, Bochud PY, Gardiner CM, O'Farrelly C, Berg T., Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection., Gut, 2016, pdoi: 10.1136/gutjnl-2015-31023
Gardiner C.M, Mills K.H.G, The cells that mediate innate immune memory and their functional significance in inflammatory and infectious diseases, Seminars in Immunology, 28, (4), 2016, p343-350
Gardiner CM, NK cell function and receptor diversity in the context of HCV infection., Frontiers in microbiology, 6, 2015, p1061
Keating SE, Ní Chorcora C, Dring MM, Stallings RL, O'Meara A, Gardiner CM, Increased frequencies of the killer immunoglobulin-like receptor genes KIR2DL2 and KIR2DS2 are associated with neuroblastoma., Tissue antigens, 86, (3), 2015, p172-7
Dunphy SE, Sweeney CM, Kelly G, Tobin AM, Kirby B, Gardiner CM, Natural killer cells from psoriasis vulgaris patients have reduced levels of cytotoxicity associated degranulation and cytokine production., Clinical immunology (Orlando, Fla.), 2015
Dunphy SE, Guinan KJ, Chorcora CN, Jayaraman J, Traherne JA, Trowsdale J, Pende D, Middleton D, Gardiner CM, 2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells., Genes and immunity, 16, (5), 2015, p301-10
Morrison, M.H., Keane, C., Quinn, L.M., (...), Bergin, C., Gardiner, C.M., IFNL cytokines do not modulate human or murine NK cell functions, Human Immunology, 75, (9), 2014, p996-1000
Donnelly RP, Loftus RM, Keating SE, Liou KT, Biron CA, Gardiner CM, Finlay DK, mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function., Journal of immunology (Baltimore, Md. : 1950), 193, (9), 2014, p4477-84
Doyle, SL, Ozaki, E, Brennan, K, Humphries, MM, Mulfaul, K, Keaney, J, Kenna, PF, Maminishkis, A, Kiang, AS, Saunders, SP, Hams, E, Lavelle, EC, Gardiner, C, Fallon, PG, Adamson, P, Humphries, P, Campbell, M, IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration, SCIENCE TRANSLATIONAL MEDICINE, 6, 2014, p230-
Keane, C., O'Shea, D., Reiberger, T., Peck-Radosavljevic, M., Farrell, G., Bergin, C., Gardiner, C.M., Variation in Both IL28B and KIR2DS3 Genes Influence Pegylated Interferon and Ribavirin Hepatitis C Treatment Outcome in HIV-1 Co-Infection, PLoS ONE, 8, (6), 2013, pe66831-
Dring MM, Morrison MH, McSharry BP, Guinan KJ, Hagan R, O'Farrelly C, Gardiner CM, Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection., PNAS, 108, (14), 2011, p5736-41
Gardiner, C.M., Morrison, M.H., Dring, M.M., Reply to KrÃ"mer et al.: Human natural killer (NK) cell inhibition by IL28A, Proceedings of the National Academy of Sciences of the United States of America, 108, (34), 2011, pE521-E522
Dunphy S, Gardiner CM, NK cells and psoriasis., Journal of Biomedicine & Biotechnology, 2011, 2011, p248317
Fadda, L, O'Connor, GM, Kumar, S, Piechocka-Trocha, A, Gardiner, CM, Carrington, M, McVicar, DW, Altfeld, M, Common HIV-1 Peptide Variants Mediate Differential Binding of KIR3DL1 to HLA-Bw4 Molecules, JOURNAL OF VIROLOGY, 85, (12), 2011, p5970-5974
Guinan KJ, Cunningham RT, Meenagh A, Dring M, Middleton D and Gardiner CM, Receptor systems controlling natural killer cell function are genetically stratified in Europe, Genes and Immunity, 11, (1), 2010, p67 - 78
Guinan KJ, Cunningham RT, Meenagh A, Gonzalez A, Dring MM, McGuinness BW, Middleton D and Gardiner CM, Signatures of natural selection and co-evolution between Killer cell immunoglobulin-like receptors (KIR) and HLA class I genes., Genes and Immunity, 11, (6), 2010, p467-478
The role of NK cells in bacterial infection in, editor(s)Zimmer, J , Natural Killer cells - at the forefront of modern immunology, Springer, 2009, [McSharry, B and Gardiner, CM]
Athie-Morales, O'Connor GM and Gardiner CM, Activation of human NK cells by the bacterial pathogen-associated molecular pattern, muramyl dipeptide, Journal of Immunology, 180, (6), 2008, p4082 - 4089
Gardiner CM, Killer cell immunoglobulin-like receptors on NK cells: the how, where and why, International Journal of Immunogenetics, 35, (1), 2008, p1 - 8
O'Connor GM, Guinan K, Cunningham RT, Middleton D, Parham P and Gardiner CM, Functional Polymorphism of the KIR3DL1/S1 Receptor on Human NK Cells., Journal of Immunology, 178, 2007, p235 - 241
O'Connor GM, Holmes A, Mulcahy F, Gardiner CM., Natural Killer cells from long-term non-progressor HIV patients are characterized by altered phenotype and function., Clinical Immunology, 124, (3), 2007, p277 - 283
O'Connor GM, Hart OM and Gardiner CM, Putting the NK cell in its Place, Immunology, 117, (1), 2006, p1 - 10
Hart OM, Athie-Morales V, O'Connor GM and Gardiner CM, TLR7/8 mediated activation of human NK cells results in accessory cell dependent IFN-gamma production, Journal of Immunology, 175, 2005, p1636 - 1642
Pando MJ, Gardiner CM, Gleimer M, McQueen KL and Parham P, The protein made from a common allele of KIR3DL1 (3DL1*004) is poorly expressed at the cell surface due to substitutions at positions 86 in Ig domain 0 and 182 in Ig domain 1, Journal of Immunology, 171, 2003, p6640 - 6649
Shilling HG, Guethlein LA, Chenng NW, Gardiner CM, Rodriguez R, Tyan D and Parham P, KIR allelic polymorphism is a major component of KIR haplotype diversity, Journal of Immunology, 168, 2002, p2307 - 2315
Gomez-Lozano N, Gardiner CM, Parham P and Vilches C, Some KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B, Immunogenetics, 54, 2002, p314 - 319
Shilling HG, Guethlein LA, Cheng NW, Gardiner CM, Tyan D and Parham P, Genetic control of human NK cell repertoires, Journal of Immunology, 169, 2002, p239 - 247
Rajalingam R, Gardiner CM, Canavez F, Vilches C and Parham P, Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors, Tissue Antigens, 57, 2001, p22 - 31
Gardiner CM, Guethlein LA, Shilling HG, Pando M, carr WH, Rajalingam R, Vilches C and Parham P, Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphism, Journal of Immunology, (166), 2001, p2992 - 3001
Vilches C, Rajalingam R, Uhrberg M, Gardiner CM, Young N and Parham P, KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of immunoglobulin-like domains, Journal of Immunology, 164, 2000, p5797 - 5804
Vilches C, Pando M, Rajalingam R, Gardiner CM and Parham P, Discovery of two novel variants of KIR2DS5 reveals this gene to be a common component of the human KIR 'B' haplotypes, Tissue Antigens, 56, 2000, p453 - 456
Vilches C, Gardiner CM and Parham P, Gene structure and promoter variation of expressed and non-expressed variants of the KIR2DL5 gene, Journal of Immunology, 165, 2000, p6416 - 6421
Gardiner CM, Quick guide: Natural Killer cells, Current Biology, 9, 1999, p716-
Gardiner CM and Reen DJ, Differential cytokine regulation of NK cell mediated cytotoxicity, Immunology, 93, 1998, p511 - 517
Gardiner CM, O'Meara A and Reen DJ, Differential cytotoxicity of cord blood and bone marrow derived NK cells, Blood, 91, 1998, p207 - 213
Gardiner CM, Reen DJ and O'Meara A, Recognition of unusual presentation of a Natural Killer cell leukaemia, American Journal of Hematology, 50, 1995, p133 - 139
Non-Peer-Reviewed Publications
Gardiner CM, Breakthroughs in understanding NK cell metabolism, Seminar Series, Stanford University, July, 2014, Prof. Peter Parham
Gardiner CM, Natural Killer cells in cancer, Seminar Series, NUI Maynooth, November, 2013, Prof. Paul Moynagh
Research Expertise
Recognition
Memberships
British Society for Immunology
Irish Society for Immunology