Drug Development

• Design, chemical synthesis and evaluation of novel molecular structures as potential clinical drugs: for breast cancerand Burkitt’s Lymphoma
• Azetidinone analogues of Combretastatin A-4 as tubulin targeting agents
• Selective Estrogen receptor modulators and tubulin-targeting drugs
• Pro-drug optimisation of our current candidates
• Synthesis and biochemistry of ER and tubulin antagonists
• Dual ER/aromatase and tubulin/aromatase targeting products
• Dual acting HSP 90 / tubulin targeting products
• Design of Multidrug resistance/P-glycoprotein modulators
• Natural Product Drug Discovery
• Anti-cancer lead discovery from Ethno-medicine (Sub-Saharan Africa, India and Pakistan) and evidence-based traditional Chinese medicine
• Anti-cancer lead discovery from natural sources (Marine, Terrestrial plants, fungi and microorganisms)
• Cross-hybridisation of naturally occurring molecules to form novel anti-cancer scaffolds

Natural Products

Pharmacy Professors Associated with Disease, Drug Mechanisms & Safety