Dr. John Walsh

• Zhang T, Finn D.F, Barlow J.W, Walsh J.J, Mast cell stabilisers, European Journal of Pharmacology, 778, 2016, p158 - 168Journal Article, 2016, DOI , URL
• Egan M, Connors E.M, Anwar Z, Walsh J.J, Nature's Treatment for Irritable Bowel Syndrome: Studies on the Isolation of (-)-Menthol from Peppermint Oil and Its Conversion to (-)-Menthyl Acetate, Journal of Chemical Education, 92, (10), 2015, p1736 - 1740Journal Article, 2015, DOI , URL
• Brian Moran, The design, synthesis and biological evaluation of novel multiple targeting anti-cancer agents, Trinity College Dublin, 2015Thesis, 2015, URL
• Denise Ropero, Phytochemical studies on Choisya x dewitteana 'Aztec Pearl', 2018Thesis, 2018
• Ijaz S, Shoaib Khan HM, Anwar Z, Talbot B, Walsh JJ, HPLC profiling of Mimosa pudica polyphenols and their non-invasive biophysical investigations for anti-dermatoheliotic and skin reinstating potential, Biomedicine & Pharmacotherapy, 109, 2019, p865 - 875Journal Article, 2019, DOI , URL , TARA - Full Text
• Finn D.F., T. Zhang T., Woods O., Walsh J.J., NOVEL MAST CELL-STABILISING ALCOHOLDERIVATIVES OF 3,4 DIHYDRONAPHTHALEN-1(2H)-ONE and 6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-ONE, Inflammation Research, The European Histamine Research Society 44th Annual Meeting, , Malaga, Spain, May 6-9, 2015, edited by G. Sturman , 64 , (Suppl 1), 2015, pp15 - 15Poster, 2015, DOI
• Zeeshan Anwar, Synthesis of Tubulin Inhibitors with Variable Molecular Hinges for the Attachment of Aminopeptidase N Targeting Moieties, Trinity College Dublin, 2019Thesis, 2019
• Ryan, T.J.; Grimes, T.; Henman, M.C.; Sheachnasaigh, E.N.; O'Dwyer, M.; Roche, C.; Ryder, S.A.; Sasse, A.; Walsh, J.J. & D'Arcy, D.M, Design and Implementation of an Integrated Competency-Focused Pharmacy Programme: A Case Report., Pharmacy, 7, (3), 2019, pdoi.org/10.3390/pharmacy703012Journal Article, 2019, DOI
• Ryan TJ, Ryder SA, D'Arcy DM, Quigley JM, Ng NN, Ong WQ, Tey ZH, O'Dwyer M, Walsh JJ., Development of Professional Attributes through Integration of Science and Practice at First-Year Pharmacy Level, Pharmacy, 2021Journal Article, 2021, DOI
• Doyle AM, Reilly J, Murphy N, Kavanagh PV, O'Brien JE, Walsh MS, Walsh JJ, Nature's sedative: Isolation and structural elucidation of valtrate from Centranthus ruber, Journal Of Chemical Education, 81, (10), 2004, p1486 - 1487Journal Article, 2004, URL
• Mills C, Cleary BJ, Gilmer JF, Walsh JJ, Inhibition of acetylcholinesterase by Tea Tree oil, Journal Of Pharmacy and Pharmacology, 56, (3), 2004, p375 - 379Journal Article, 2004, URL
• Cunningham D, Grayson DH, McArdle P, Walsh JJ, The bromination of (-)-camphorquinone, Tetrahedron-Asymmetry, 14, (9), 2003, p1197 - 1200Journal Article, 2003, URL
• Carolan JC, Hook ILI, Walsh JJ, Hodkinson TR, Using AFLP markers for species differentiation and assessment of genetic variability of in vitro-cultured Papaver bracteatum (section Oxytona), In Vitro Cellular & Developmental Biology-Plant, 38, (3), 2002, p300 - 307Journal Article, 2002, URL
• Anwar N, Khan A, Shah M​, Walsh JJ, Saleem S, Anwar Z, Aslam S, Irshad M., Hybridization of green synthesized silver nanoparticles with poly(ethylene glycol) methacrylate and their biomedical applications., PeerJ , (10), 2022, p1 - 28Journal Article, 2022
• Simplício AL, Gilmer JF, Frankish N, Sheridan H, Walsh JJ, Clancy JM., Ionisation characteristics and elimination rates of some aminoindanones determined by capillary electrophoresis, Journal of Chromatography A, 1045, (1/2), 2004, p233 - 238Journal Article, 2004, URL
• Quanxiang Yan, Tao Zhang, Christine O'Connor, James W. Barlow, John Walsh, Gaia Scalabrino, Feng Xu, Helen Sheridan, The biological responses of vitamin K2: A comprehensive review, Food Science & Nutrition, 00, 2023, p1 - 23Journal Article, 2023
• Collyer, Samuel E., Gary D. Stack, and John J. Walsh, Selective Delivery of Clinically Approved Tubulin Binding Agents through Covalent Conjugation to an Active Targeting Moiety, CURRENT MEDICINAL CHEMISTRY, 29, (31), 2022, p5179 - 5211Journal Article, 2022
• MJ Lyons, C Ehrhardt, JJ Walsh, Orellanine: From fungal origins to a future cancer treatment, J Nat Prod, 86, (6), 2023, p620-1631Review Article, 2023, URL
• Sheridan H, Butterly S, Walsh JJ, Cogan C, Jordan M, Nolan O, Frankish N, Synthesis and pharmacological activity of aminoindanone dimers and related compounds, Bioorganic and Medicinal Chemistry, 16, (1), 2008, p248 - 254Journal Article, 2008, URL
• Davis AP, Walsh JJ, Amide bond formation via pentafluorothiophenyl active esters, Tetrahedron Letters, 35, (27), 1994, p4865 - 4868Journal Article, 1994, URL
• Davis AP, Menzer S, Walsh JJ. , Steroid-based receptors with tunable cavities; A series of polyhydroxylated macrocycles of varying size and flexibility, Chemical Communications , 1996, p453 - 456Journal Article, 1996, URL
• Davis AP, Walsh JJ., Steroid-based receptors with tunable cavities; Stepwise and direct syntheses of a C-3-symmetrical prototype, Chemical Communications, 1996, p449 - 451Journal Article, 1996, URL
• Walsh JJ, Hook I, Kavanagh P, Reininger R., Naphthoquinone production by cultures of cape sundew (Drosera capensis), Pharmacy/Pharmacoloy Letters, 7, 1997, p93 - 95Journal Article, 1997
• Comey N, Hook I, Sheridan H, Walsh J, James P., Isolation of (S)-(-)-2,3-dihydro-2,6-dimethyl-4H-benzopyran-4-one from roots of Leontopodium alpinum, Journal of Natural Products., 60, (2), 1997, p148 - 148-149Journal Article, 1997, URL
• Walsh JJ, Walsh MS, Ni Bhrangain S, Kavanagh PV and Feely J, Red Valerian-Nature's Sedative, Irish Journal of Medical Science, 168, (141), 1999, p143-Journal Article, 1999
• Walsh JJ, Frankish NF, Sheridan H, Byrne W. Farrell R, Indane dimer compounds and their pharmaceutical use, 2001, US6300376Patent, 2001
• Walsh JJ, Frankish NF, Sheridan H, Byrne W, Indane compounds with smooth muscle relaxing and/or mast cell stabilising and/or anti-inflammatory activity, 2001, US6297399Patent, 2001
• Walsh JJ, Frankish NF, Sheridan H, Byrne W, Indane dimer compounds with smooth muscle relaxing and/or mast cell stabilising and/or anti-inflammatory activity, 2002, US6423752Patent, 2002
• Walsh JJ, Frankish NF, Sheridan H, Byrne W, Jordan M, Indane compounds and their pharmaceutical use, 2002, US6433021Patent, 2002
• Walsh JJ, McCormack EM, Shah R, Endothelium as a target in the design of novel tumour vasculature targeting agents, Anticancer Research: Special edition, 24, 2004, p527 - 528Journal Article, 2004
• Douglas RH, Muldowney CA, Mohamed R, Keohane F, Shanahan C, Kavanagh PV, Walsh JJ, Detection and quantification of valerenic acid in commercially available valerian products, Journal of Chemical Education, 84, (5), 2007, p829 - 831Journal Article, 2007, URL
• Walsh JJ, Coughlan D, Heneghan N, Gaynor C, Bell A, A novel artemisinin-quinine hybrid with potent antimalarial activity, Bioorganic and Medicinal Chemistry Letters, 17, (13), 2007, p3599 - 3602Journal Article, 2007, URL
• Walsh JJ, Treacy S, Dunne A, Kavanagh PV, A Simple Method For The Identification of Common Herbal/Alternative health products by Gas Chromatography/Mass Spectrometry, 12th International symposium on separation sciences, Lipica, Slovenia, Sept 27-29, 2006, pp334-Meeting Abstract, 2006
• Kavanagh PV, McCarthy S, Walsh JJ, Identification and quantitation of lovastatin in red yeast rice, 12th International symposium on separation sciences, Lipica, Slovenia, Sept 27-29, 2006, pp335-Meeting Abstract, 2006
• White M, Walsh JJ., Sodium Azide: A mild and selective deprotecting reagent for use in the synthesis of novel inhibitors of endothelial cell proliferation, Fifth interdisciplinary euroconference on angiogenesis, Sitges, Spain , May 27-30, 2005, pp114-Meeting Abstract, 2005
• Byrne A, Walsh JJ, Studies on the Mast cell stabilising properties of plant extracts with reputed anti-inflammatory activity, 34th meeting of the European histamine research society, Bled, Slovenia, 2005 May 11-14, 2005, pp7-Meeting Abstract, 2005
• Byrne A, Donnelly C, Mills C, Walsh JJ, A study on the mast cell stabilising properties of Sargentodoxa cuneata, 33rd annual meeting of theEuropean histamine research society, Düsseldorf / Köln, Germany, Apr 28-May2, 2004, pp29-Meeting Abstract, 2004
• Screening for aminopeptidase inhibitors using silica gel thin layer chromatography, Hudson GJ, Ryan EP, Walsh JJ, British Microcirculation Society, 41st Scientific meeting and symposium: Tumour microcirculation: Development and Therapeutic targets, Sheffield, Apr 5-6, 2004, pp37-Meeting Abstract, 2004
• Walsh JJ, Coughlan D, Heneghan N, Gaynor C, Bell A., A novel artemisinin-quinine hybrid with antimalarial activity., 11th International Congress of Parasitology, Glasgow, Aug, 2006Meeting Abstract, 2006
• Barlow JW, Walsh JJ, Synthesis and evaluation of 4-amino-3,4-dihydro-2H-naphthalen-1-one derivatives as mast cell stabilising and anti-inflammatory compounds, European Journal of Medicinal Chemistry, 43, (12), 2008, p2891 - 2900Journal Article, 2008, URL
• Walsh JJ and Bell A, Hybrid Drugs for Malaria, Current Pharmaceutical Design, 15(25), 2009, p2970-85Journal Article, 2009, URL
• Sheridan H, Walsh JJ, Cogan C, Jordan M, McCabe T, Passante E, Frankish NH, Diastereoisomers of 2-Benzyl-2, 3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol: Potent anti-inflammatory agents, Bioorganic & Medicinal Chemistry Letters, 19, 2009, p5927 - 5930Journal Article, 2009, DOI
• Breen EC and Walsh JJ, Tubulin-targeting agents in hybrid drugs., Current Medicinal Chemistry, 17, (7), 2010, p609 - 639Journal Article, 2010, URL
• Sheridan H, Walsh JJ, Jordan M, Cogan C, Frankish N., A series of 1, 2-coupled indane dimers with mast cell stabilisation and smooth muscle relaxation properties., European Journal of Medicinal Chemistry, 44, (12), 2009, p5018 - 5022Journal Article, 2009, URL
• Barlow JW, Walsh JJ., Synthesis and evaluation of dimeric 1,2,3,4-tetrahydro-naphthalenylamine and indan-1-ylamine derivatives with mast cell-stabilising and anti-allergic activity., European Journal of Medicinal Chemistry, 45, (1), 2010, p25 - 37Journal Article, 2010, URL
• O'Byrne PM, Williams R, Walsh JJ, Gilmer JF., The aqueous stability of bupropion, Journal of Pharmaceutical and Biomedical Analysis, 53, (3), 2010, p376 - 381Journal Article, 2010, URL
• Adam J. Byrne, James W. Barlow, John J. Walsh, Synthesis and pharmacological evaluation of the individual stereoisomers of 3- [methyl(1,2,3,4-tetrahydro-2-naphthalenyl)amino]-1-indanone, a potent mast cell stabilising agent, Bioorganic & Medicinal Chemistry Letters, 21, (4), 2011, p1191-1194Journal Article, 2011, DOI , URL , TARA - Full Text
• James W. Barlow, Aengus P. McHugh, Orla Woods, John J. Walsh, Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds, European Journal of Medicinal Chemistry, 46, (5), 2011, p1545-1554Journal Article, 2011, DOI , URL , TARA - Full Text
• Catherine M. Halpin, Ciara Reilly, and John J. Walsh, Nature's Anti-Alzheimer's Drug: Isolation and Structure Elucidation of Galantamine from Leucojum aestivum, Journal of Chemical Education, 87 , (11), 2010, p1242 - 1243Journal Article, 2010, URL
• Gary D. Stack and John J. Walsh, Optimising the Delivery of Tubulin Targeting Agents through Antibody Conjugation., Pharmaceutical Research, 29, (11), 2012, p2972 - 2984Journal Article, 2012, URL
• Anne-Marie Carroll, David J. Kavanagh, Fiona P. McGovern, Joe W. Reilly, and John J. Walsh, Nature's Chiral Catalyst and Anti-Malarial Agent: Isolation and Structure Elucidation of Cinchonine and Quinine from Cinchona calisaya, Journal of Chemical Education, 89, 2012, p1578 - 1581Journal Article, 2012, URL
• Maisarah Mohd Nazri, Farah D. Samat, Pierce V. Kavanagh, and John J. Walsh, Nature's Cholesterol-Lowering Drug: Isolation and Structure Elucidation of Lovastatin from Red Yeast Rice-Containing Dietary Supplements, Journal of Chemical Education, 89, 2012, p138 - 140Journal Article, 2012, URL
• Emma L. Walsh, Siobhan Ashe, and John J. Walsh, Nature's Migraine Treatment: Isolation and Structure Elucidation of Parthenolide from Tanacetum parthenium, Journal of Chemical Education, 89, 2012, p134 - 137Journal Article, 2012, URL
• Prokopiou EM, Ryder SA, Walsh JJ, Tumour vasculature targeting agents in hybrid/conjugate drugs., Angiogenesis, 16, (3), 2013, p503 - 524Journal Article, 2013, DOI , URL , TARA - Full Text
• Finn, D.F., Walsh, J.J., Twenty-first century mast cell stabilizers, British Journal of Pharmacology, 170, (1), 2013, p23-37Journal Article, 2013, DOI , TARA - Full Text
• Prokopiou, E.M., Ryder, S.A., Walsh, J.J., Tumour vasculature targeting agents in hybrid/conjugate drugs, Angiogenesis, 16, (3), 2013, p503-524Journal Article, 2013, DOI
• Carroll, A.-M., Kavanagh, D.J., McGovern, F.P., Reilly, J.W., Walsh, J.J., Natures chiral catalyst and anti-malarial agent: Isolation and structure elucidation of cinchonine and quinine from cinchona calisaya, Journal of Chemical Education, 89, (12), 2012, p1578-1581Journal Article, 2012, DOI
• Linker technologies and release mechanisms for antibody-drug conjugates in, editor(s)Professor Norbert Sewald , Optimizing antibody-drug conjugates for targeted delivery of therapeutics, Future press, 2015, pp40 - 55, [John J. Walsh and Gary D. Stack ]Book Chapter, 2015, DOI
• Bopha Chrea, Juliette A. O'Connell, Orlando Silkstone-Carter, John O'Brien, and John J. Walsh, Nature's Antidepressant for Mild to Moderate Depression: Isolation and Spectral Characterization of Hyperforin from a Standardized Extract of St. John's Wort (Hypericum perforatum), Journal of Chemical Education, 91, (3), 2014, p440 - 442Journal Article, 2014, URL
• Paul Matthew O'Byrne, Robert Williams, John J. Walsh, John Gilmer, Synthesis, screening and pharmacokinetic evaluation of potential prodrugs of bupropion, Pharmaceuticals, 7, (5), 2014, p595 - 620Journal Article, 2014, DOI , TARA - Full Text
• Paul Matthew O'Byrne, Robert Williams, John J. Walsh, John Gilmer, Part Two: Evaluation of N-methylbupropion as a Potential Bupropion Prodrug, Pharmaceuticals, 7, (6), 2014, p676 - 694Journal Article, 2014, DOI , TARA - Full Text

• C Ehrhardt, S Nickel, MA Selo, CG Clerkin, JJ Salomon, B Talbot, JJ Walsh, OCTN1-mediated ergothioneine uptake protects lung epithelial cells from tobacco smoke-induced damage, FASEB J, Experimental Biology Meeting 2015, Boston, MA, 28/03-01/04/2015, 29, 2015, pp970.7Meeting Abstract
• CG Clerkin, M Matzinger, MA Selo, BN Talbot, JJ Walsh, C Ehrhardt, Nucleophilic substitution reactions of ergothioneine might be a novel xenobiotic deactivation mechanism, 32nd Annual Meeting of the Japanese Society for the Study of Xenobiotics, Tokyo, Japan, 29/11-01/12/2017, 2017Oral Presentation
• O'Dwyer M, Ryan T, Ryder S, D'Arcy DM, Walsh J. , Innovative Development and Evaluation of Professional Attributes through Integration of Science and Practice at First Year Pharmacy Level , Irish Network of Healthcare Educators Conference, TBSI, Trinity College Dublin, Dublin, Ireland , February 2020, 2020Oral Presentation

Drug discovery, Assay development, Tumour Angiogenesis, Tumour Vasculature, Endothelial cells, Tubulin, Proteases, Integrins, Vascular Endothelial Growth Factor, Allergies, Mast cells, Basophils, Histamine, Malaria, Natural Products, Herbal Medicinal Products. Research students supervised: PhD graduates: Dr James Barlow (Jan 2003); Dr Emmet McCormack (Apr 2003); Dr Richard Shah (Apr 2003); Dr Adam Byrne (Jun 2007); Dr Gillian Hudson (Jun 2007); Dr Martina White (Sept 2008); Dr Tao Zhang (February 2010); Dr Orla Woods, (December 2010); Dr Paul O'Byrne (Conjoint with JG), (December 2010); Dr Deirdre Finn, (October 2011), Dr Elaine Breen (December 2012), Dr Ekatherine Prokopiou (Conjoint with SR) (January 2013), Dr Gary Stack (July 2013), Dr Adrian Coogan (August 2013). MSc students supervised: Sharon Butterly Jun 1998 (Conjoint with NF); Aengus McHugh (Apr 2007); William Casey, (November 2010); Miriam Holohan (October 2011).

• Title

  Development of Dual Inhibitors of Tumour Angiogenesis/Vasculature
  Summary
  Funding Agency

  Enterprise Ireland
  Date From

  Oct 2008
  Date To

  Sept 2011
• Title

  Studies on Novel Mast Cell Stabilising Compounds
  Summary
  Funding Agency

  Irish Research Council For Science Engineering and Technology
  Date From

  01-10-2008
  Date To

  30-09-2009
• Title

  Endothelium as a Target in the Design of Novel Anti-cancer agents
  Summary

  T05009
  Funding Agency

  Cancer Research Ireland
  Date From

  Oct. 2003
  Date To

  Sept. 2006
• Title

  Synthesis and evaluation of tunable cyclolactams for antimalarial therapy
  Summary

  In collaboration with Dr Aongus Bell, Department of Microbiology, TCD: PC/2003/013: Proof of Concept
  Funding Agency

  Enterprise Ireland
  Date From

  Jan. 2004
  Date To

  Apr. 2005
• Title

  Design of Tumour Homing Vasculature Targeting Agents
  Summary
  Funding Agency

  Irish Research Council for Science Engineering and Technology
  Date From

  01-10-2008
  Date To

  30-09-2011
• Title

  Discovery of Novel Anti-cancer compounds
  Summary

  HE/98/249: Applied Research Grant
  Funding Agency

  Enterprise Ireland
  Date From

  Oct. 1998
  Date To

  Mar. 2001
• Title

  Design of Hybrid-based Tumour Homing Anti-angiogenesis Agents
  Summary
  Funding Agency

  Irish Research Council for Science Engineering and Technology
  Date From

  01-10-2008
  Date To

  30-09-2011
• Title

  Pre-clinical Development of Novel Anti-allergic Compounds
  Summary

  Allergy Research: IF/2001/014: Research Innovation Fund.
  Funding Agency

  Enterprise Ireland
  Date From

  Dec 2001
  Date To

  Apr. 2004
• Title

  Pre-clinical Development of Novel Anti-allergic Compounds
  Summary
  Funding Agency

  Enterprise Ireland
  Date From

  Oct 2004
  Date To

  Mar 2009

• Henkel Award (Organic Chemistry)

• European Histamine Research Society to date
• Phytochemical Society of Europe to date

• Ireland representative on Committee 13b of the European Pharmacopoeia, Strasbourg. 2016
• Ireland representative on Committee 13b of the European Pharmacopoeia, Strasbourg. 2016