Professor Anne-Marie Healy

• Amaro MI, Tewes F, Gobbo O, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Formulation, stability and pharmacokinetics of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation, International Journal of Pharmaceutics, 483, (1-2), 2015, p6-18Journal Article, 2015, DOI , TARA - Full Text
• Dul M, Paluch KJ, Kelly H, Healy AM, Sasse A, Tajber L, Self-assembled carrageenan/protamine polyelectrolyte nanoplexes-investigation of critical parameters governing their formation and characteristics, Carbohydrate Polymers, 123, 2015, p339 - 349Journal Article, 2015, DOI , URL
• D. R. Serrano, T. Persoons, D. M. D'Arcy, C. Galiana, M. A. Dea-Ayuela, A. M. Healy, Shadowgraph Imaging of Cocrystal Dissolution and In Vitro Activity Determination , AAPS Annual Meeting and Exposition, Orlando, Florida, USA, Oct 25-29, 2015, ppW5128-Conference Paper, 2015, URL
• Knopp MM, Tajber L, Tian Y, Olesen NE, Jones DS, Kozyra A, Löbmann K, Paluch K, Brennan CM, Holm R, Healy AM, Andrews GP, Rades T, Comparative study of different methods for the prediction of drug-polymer solubility, Molecular Pharmaceutics, 12, (9), 2015, p3408 - 3419Journal Article, 2015, DOI , TARA - Full Text
• Tewes, F, Gobbo, OL, Ehrhardt, C, Healy, AM, Amorphous calcium carbonate based-microparticles for peptide pulmonary delivery, ACS Applied materials and interfaces, 8, (2), 2016, p1164-1175Journal Article, 2016, DOI , TARA - Full Text
• Simon A, Amaro MI, Cabral LM, Healy AM, de Sousa VP, Development of a novel dry powder inhalation formulation for the delivery of rivastigmine hydrogen tartrate, International journal of pharmaceutics, 501, (1-2), 2016, p124-38Journal Article, 2016, DOI , TARA - Full Text
• Tewes F, Brillault J, Lamy B, O'Connell P, Olivier JC, Couet W, Healy AM, Ciprofloxacin-loaded inorganic-organic composite microparticles to treat bacterial lung infection, Molecular pharmaceutics, 13, (1), 2016, p100-12Journal Article, 2016, DOI
• Amharar Y, Curtin V, Gallagher KH, O'Siochru E, O'Connell P, Healy AM, Mitigating unwanted amorphisation: A screening method for the selection of suitable excipients, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 81, 2016, p181-8Journal Article, 2016, DOI , TARA - Full Text
• Serrano DR, O'Connell P, Paluch KJ, Walsh D, Healy AM, Cocrystal habit engineering to improve drug dissolution and alter derived powder properties, The Journal of pharmacy and pharmacology, 68, (5), 2016, p665-7Journal Article, 2016, DOI , TARA - Full Text
• Serrano DR, Gallagher KH, Healy AM, Emerging nanonisation technologies: tailoring crystalline versus amorphous nanomaterials, Current topics in medicinal chemistry, 15, (22), 2015, p2327-40Review Article, 2015, DOI , TARA - Full Text
• Amaro MI, Simon A, Cabral LM, de Sousa VP, Healy AM, Rivastigmine hydrogen tartrate polymorphs: solid-state characterisation of transition and polymorphic conversion via milling, Solid State Sciences, 49, 2015, p29 - 36Journal Article, 2015, DOI , TARA - Full Text
• Mackie CA, Healy AM, Roberts K, Ryder S, A comparison of community pharmacy methadone services between Dublin and Glasgow: (1) Extent of service provision in 1997/1998 and views of pharmacists on existing provision and future service developments, Journal of Substance Use, 9, (5), 2004, p235 - 251Journal Article, 2004
• McCarthy LG, Bradley G, Sexton JC, Corrigan OI, Healy AM, Computational fluid dynamics (CFD) modeling of the paddle dissolution apparatus: agitation rate, mixing patterns and fluid velocities, AAPS PharmSciTech (http://www.aapspharmscitech.org), 5, (2), 2004, pE31Journal Article, 2004, URL
• Crane M, Hurley N, Crane L, Healy AM, Corrigan OI, Gallagher KM, McCarthy LG, Simulation of the USP drug delivery problem using CFD: experimental, numerical and mathematical aspects, Simulation Modelling Practice and Theory, 12, (2), 2004, p147 - 158Journal Article, 2004
• Corrigan DO, Healy AM, Corrigan OI, The effect of spray drying solutions of bendroflumethiazide/polyethylene glycol on the physicochemical properties of the resultant materials, International Journal of Pharmaceutics, 262, (1-2), 2003, p125 - 137Journal Article, 2003
• McCarthy LG, Kosiol C, Healy AM, Bradley G, Sexton JC, Corrigan OI, Simulating the hydrodynamic conditions in the United States Pharmacopeia paddle dissolution apparatus, AAPS PharmSciTech (http://www.aapspharmscitech.org), 4, (2), 2003, pE22Journal Article, 2003, URL
• Healy AM, McCarthy LG, Gallagher KM, Corrigan OI, Sensitivity of dissolution rate to location in the paddle dissolution apparatus, Jourrnal of Pharmacy and Pharmacology, 54, (3), 2002, p441 - 444Journal Article, 2002, DOI
• Corrigan DO, Healy AM, Corrigan OI, The effect of spray drying solutions of polyethylene glycol (PEG) and lactose/PEG on their physicochemical properties, International Journal of Pharmaceutics, 235, (1-2), 2002, p193 - 205Journal Article, 2002, DOI
• Serrano DR, Persoons T, D'Arcy DM, Galiana C, Dea-Ayuela MA, Healy AM, Modelling and shadowgraph imaging of cocrystal dissolution and assessment of in vitro antimicrobial activity for sulfadimidine/4-aminosalicylic acid cocrystals, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 89, 2016, p125-36Journal Article, 2016, DOI , TARA - Full Text
• Zelikin AN, Ehrhardt C, Healy AM, Materials and methods for delivery of biological drugs, Nature Chemistry, 8, (11), 2016, p997-1007Review Article, 2016, DOI
• Healy AM, Corrigan OI, The influence of excipient particle size, solubility and acid strength on the dissolution of an acidic drug from two-component compacts, International Journal of Pharmaceutics, 143, 1996, p211 - 221Journal Article, 1996
• Crane M, Crane L, Healy AM, Corrigan OI, Gallagher KM, McCarthy LG, Pohlhausen solution for the mass flux from a multi-layered compact in the USP drug dissolution apparatus, Simulation Modelling Practice and Theory, 12, (6), 2004, p397 - 411Journal Article, 2004
• Healy AM, Corrigan OI, Allan JEM, The effect of dissolution on the surface texture of model pharmaceutical systems as assessed by non-contact laser profilometry, Pharmaceutical Technology Europe, 7, (8), 1995, p14 - 22Journal Article, 1995
• Healy AM, Corrigan OI, Dissolution testing of enteric coated aspirin tablets, Irish Pharmacy Journal, 75, (6), 1997, p189 - 190Journal Article, 1997
• Surfactants in pharmaceutical products and systems in, editor(s)Swarbrick J and Boylan JC , Encyclopedia of Pharmaceutical Technology 2nd Edition, New York, Marcel Dekker, 2002, pp2639 - 2653, [Corrigan OI, Healy AM]Book Chapter, 2002
• Surfactants in pharmaceutical products and systems in, editor(s)Swarbrick J and Boylan JC , Encyclopedia of Pharmaceutical Technology Volume 14, New York, Marcel Dekker, 1996, pp295 - 331, [Corrigan OI, Healy AM]Book Chapter, 1996
• Tajber, L., Healy, A.M. and Corrigan, O.I., The effect of polyvinylpyrrolidone content on the glass transition temperature of thiazide diuretics, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, Germany, 15-18 March, 2004, pp711 - 712Meeting Abstract, 2004
• Simon A, Amaro MI, Healy AM, Cabral LM, de Sousa VP, Comparative evaluation of rivastigmine permeation from a transdermal system in the Franz cell using synthetic membranes and pig ear skin with in vivo-in vitro correlation, International Journal of Pharmaceutics, 512, (1), 2016, p234 - 241Journal Article, 2016, DOI , URL , TARA - Full Text
• Serrano DR, Mugheirbi NA, O'Connell P, Leddy N, Healy AM, Tajber L, Impact of substrate properties on the formation of spherulitic films: a case study of salbutamol sulfate, Crystal Growth and Design, 16, (7), 2016, p3853 - 3858Journal Article, 2016, DOI , URL , TARA - Full Text
• D'Arcy, D.M., Corrigan, O.I. and Healy, A.M., Analysis of variation in dissolution rate with position in the USP paddle apparatus using computational fluid dynamics, European Conference on Drug Delivery and Pharmaceutical Technology, Seville, Spain, May, 2004, pp64 (abstract)Meeting Abstract, 2004
• McCarthy, L.G., Corrigan, O.I. and Healy, A.M., Modelling drug release from multi-layered compacts with potential for zero-order release kinetics, European Conference on Drug Delivery and Pharmaceutical Technology, Seville, Spain, May, 2004, pp152 (abstract)Meeting Abstract, 2004
• Healy, AM, Worku, ZA, Kumar, D, Madi, AM, Pharmaceutical solvates, hydrates and amorphous forms: a special emphasis on cocrystals, Advanced Drug Delivery Reviews, 117, 2017, p25-46Review Article, 2017, DOI , TARA - Full Text
• Todaro, V, Persoons, T, Groves, G, Healy, AM, D'Arcy, DM, Characterisation and simulation of hydrodynamics in the paddle, basket and flow-through dissolution testing apparatuses - a review, Dissolution Technologies, 24, (3), 2017, p24 - 36Journal Article, 2017, DOI
• Rolón M, Serrano DR, Lalatsa A, de Pablo E, Torrado JJ, Ballesteros MP, Healy AM, Vega, C, Corone C, Bolás-Fernández F, Dea-Ayuela MA, Engineering oral and parenteral amorphous amphotericin B formulations against experimental Trypanosoma cruzi infections, Molecular Pharmaceutics, 14, (4), 2017, p1095-1106Journal Article, 2017, DOI , URL
• Simon A, Amaro MI, Healy AM, Cabral LM, de Sousa VP, Development of a discriminative in vitro release test for rivastigmine transdermal patches using pharmacopeial apparatuses: USP 5 and USP 6, AAPS PharmSciTech, 18 , (7), 2017, 2561-2569Journal Article, 2017, DOI , TARA - Full Text
• Surfactants in pharmaceutical products and systems. in, editor(s)Swarbrick J and Boylan JC , Encyclopedia of Pharmaceutical Science and Technology 4th Edition, New York, Taylor and Francis, 2013, pp3464 - 3476, [Tewes F, Corrigan OI, Healy AM]Book Chapter, 2013
• Surfactants in pharmaceutical products and systems in, editor(s)Swarbrick J , Encyclopedia of Pharmaceutical Technology 3rd Edition, New York, Taylor and Francis, 2006, pp3583 - 3596, [Corrigan OI, Healy AM]Book Chapter, 2006
• Caron V, Tajber L, Corrigan OI, Healy AM, Production of amorphous dispersions of sulfonamides/polyvinylpyrrolidone by ball milling, Journal of Pharmacy and Pharmacology, UK-PharmSci 2010, Nottingham, UK, 2010, 62, (10), 2010, pp1347 - 1348Conference Paper, 2010
• McDonnell D, Redmond B, D'Arcy DM, Healy AM, Corrigan OI, An analysis of drug dissolution rates in the USP 24 type 2 apparatus, Proceedings in Applied Mathematics and Mechanics (PAMM), 80th Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM), Gdansk, 9 - 13 February 2009, 9, (1), 2009, pp691 - 692Conference Paper, 2009
• McMahon NM, Crane LJ, Ruskin HJ, Crane M, D'Arcy DM, Healy AM, Corrigan OI, A numerical model of a drug particle dissolving in a dissolution test apparatus, Proceedings in Applied Mathematics and Mechanics (PAMM), 80th Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM), Gdansk, 9 - 13 February 2009, 9, (1), 2009, pp655 - 656Conference Paper, 2009
• Holmes MS, Seheult JN, O'Connell P, D'Arcy S, Ehrhardt C, Healy AM, Costello RW, Reilly RB, Exhaling into a Diskus (TM) inhaler before inhalation has a detrimental effect on subsequent drug delivery, Irish Journal of Medical Science, , 182, (Suppl 10), 2013, ppS452 - S453Conference Paper, 2013
• Pharmaceutical Technology Europe, UBM plc/Americas, [eds.], 2005-2020Editorial Board, 2005
• Molecular Pharmaceutics, ACS Publications, [eds.], 2013-2020Editorial Board, 2013
• Corrigan DO, Corrigan OI, Healy AM, Predicting the physical state of spray dried composites: salbutamol sulphate/lactose and salbutamol sulphate/polyethylene glycol co-spray dried systems, International Journal of Pharmaceutics, 273, (1-2), 2004, p171 - 182Journal Article, 2004, DOI
• Tajber L, Healy AM, Corrigan OI, Physicochemical evaluation of PVP-thiazide diuretic interactions in co-spray dried composites - analysis of glass transition composition relationships, European Journal of Pharmaceutical Sciences, 24, (5), 2005, p553 - 563Journal Article, 2005
• Healy AM, Corrigan OI, Dissolution testing of five brands of tamoxifen citrate tablets available in the Republic of Ireland, Irish Pharmacy Journal, 72, (10), 1994, p306 - 311Journal Article, 1994
• Dul M, Paluch KJ, Healy AM, Sasse A, Tajber L, Optimisation of the self-assembly process: production of stable, alginate-based polyelectrolyte nanocomplexes with protamine, Journal of Nanoparticle Research, 19, (6), 2017, p221 - 231Journal Article, 2017, DOI , TARA - Full Text
• Worku ZA, Kumar D, Gomes JV, He Y, Glennon B, Ramisetty KA, Rasmuson ÅC, O'Connell P, Gallagher KH, Woods T, Shastri NR, Healy AM , Modelling and understanding powder flow properties and compactability of selected active pharmaceutical ingredients, excipients and physical mixtures from critical material properties, International Journal of Pharmaceutics, 531, (1), 2017, p191-204Journal Article, 2017, DOI , URL , TARA - Full Text
• Wang J, Radics G, Whelehan M, OÊ"Driscoll A, Healy AM, Gilmer JF, Ledwidge M, Novel Iron-Whey Protein Microspheres Protect Gut Epithelial Cells from Iron-Related Oxidative Stress and Damage and Improve Iron Absorption in Fasting Adults, Acta Haematologica, 2018, p223-232Journal Article, 2018, DOI , URL
• Kumar D, Worku ZA, Gao Y, Kamaraju VK, Glennon B, Babu RP, Healy AM, Comparison of wet milling and dry milling routes for ibuprofen pharmaceutical crystals and their impact on pharmaceutical and biopharmaceutical properties, Powder Technology, 330, 2018, p228-238Journal Article, 2018, DOI , URL , TARA - Full Text
• Serrano DR, Walsh D, O'Connell P, Mugheirbi NA, Work, ZA, Bolas-Fernandez F, Galiana C, Dea-Ayuela MA, Healy AM, Optimising the in vitro and in vivo performance of oral cocrystal formulations via spray coating, European Journal of Pharmaceutics and Biopharmaceutics, 124, 2018, p13-27Journal Article, 2018, DOI , URL , TARA - Full Text
• Lamy B, Tewes F, Serrano DR, Lamarche I, Gobin P, Couet W, Healy AM, Marchand S, New aerosol formulation to control ciprofloxacin pulmonary concentration, Journal of Controlled Release, 271, 2018, p118-126Journal Article, 2018, DOI , URL
• Walsh D, Serrano DR, Worku ZA, Norris BA, Healy AM, Production of cocrystals in an excipient matrix by spray drying, International Journal of Pharmaceutics, 536, (1), 2018, p467-477Journal Article, 2018, DOI , URL , TARA - Full Text
• Mugheirbi NA, O'Connell P, Serrano DR, Healy AM, Taylor LS, Tajber L, A Comparative Study on the Performance of Inert and Functionalized Spheres Coated with Solid Dispersions Made of Two Structurally Related Antifungal Drugs, Molecular Pharmaceutics, 14, (11), 2017, p3718-3728Journal Article, 2017, DOI , URL
• Kavanagh ON, Albadarin AB, Croker DM, Healy AM, Walker GM., Maximising success in multidrug formulation development: A review., Journal of controlled release : official journal of the Controlled Release Society, 283, 2018, p1-19Review Article, 2018, DOI
• Kelleher JF, Gilvary GC, Madi AM, Jones DS, Li S, Tian Y, Almajaan A, Senta-Loys Z, Andrews GP, Healy AM., A comparative study between hot-melt extrusion and spray-drying for the manufacture of anti-hypertension compatible monolithic fixed-dose combination products., International journal of pharmaceutics, 545, (1-2), 2018, p183-196Journal Article, 2018, DOI , TARA - Full Text
• do Amaral, L.H., do Carmo, F.A., Amaro, M.I., de Sousa, V.P., da Silva, L.C.R.P., de Almeida, G.S., Rodrigues, C.R., Healy, A.M., Cabral, L.M., Development and characterization of dapsone cocrystal prepared by scalable production methods, AAPS PharmSciTech , 19, (6), 2018, p2687 - 2699Journal Article, 2018, DOI , TARA - Full Text
• Walsh D, Serrano DR, Worku ZA, Madi AM, O'Connell P, Twamley B, Healy AM., Engineering of pharmaceutical cocrystals in an excipient matrix: Spray drying versus hot melt extrusion., International journal of pharmaceutics, 551, (1-2), 2018, p241-256Journal Article, 2018, DOI , TARA - Full Text
• Suzuki ÉY, Amaro MI, de Almeida GS, Cabral LM, Healy AM, de Sousa VP., Development of a new formulation of roflumilast for pulmonary drug delivery to treat inflammatory lung conditions., International journal of pharmaceutics, 550, (1-2), 2018, p89-99Journal Article, 2018, DOI , TARA - Full Text
• Todaro V, Worku ZA, Cabral LM, Healy AM., In Situ Cocrystallization of Dapsone and Caffeine during Fluidized Bed Granulation Processing, AAPS PharmSciTech, 20:28, (1), 2019Journal Article, 2019, DOI , TARA - Full Text
• Browne E, Charifou R, Worku ZA, Babu RP, Healy AM., Amorphous solid dispersions of ketoprofen and poly-vinyl polymers prepared via electrospraying and spray drying: A comparison of particle characteristics and performance., International journal of pharmaceutics, 566, 2019, p173-184Journal Article, 2019, DOI , TARA - Full Text
• Andrews GP, Jones DS, Senta-Loys Z, Almajaan A, Li S, Chevallier O, Elliot C, Healy AM, Kelleher JF, Madi AM, Gilvary GC, Tian Y., The Development of an Inline Raman Spectroscopic Analysis Method as a Quality Control Tool for Hot Melt Extruded Ramipril Fixed-dose Combination Products., International journal of pharmaceutics, 2019Journal Article, 2019, DOI
• Matji A, Donato N, Gagol A, Morales E, Carvajal L, Serrano DR, Worku ZA, Healy AM, Torrado JJ., Predicting the critical quality attributes of ibuprofen tablets via modelling of process parameters for roller compaction and tabletting., International journal of pharmaceutics, 565, 2019, p209-218Journal Article, 2019, DOI
• Focaroli S, Mah PT, Hastedt JE, Gitlin I, Oscarson S, Fahy JV, Healy AM., A Design of Experiment (DoE) approach to optimise spray drying process conditions for the production of trehalose/leucine formulations with application in pulmonary delivery., International journal of pharmaceutics, 562, 2019, p228-240Journal Article, 2019, DOI
• Nanoparticle Tracking Analysis to Examine the Temperature-Induced Aggregation of Proteins in, editor(s)McManus, J.J. , Protein Self-Assembly: Methods and Protocols , New York, Humana Press, 2019, pp131 - 139, [Sladek S., McComiskey K., Healy A.M., Tajber L.]Book Chapter, 2019, DOI
• Andrews, G.P. and Jones, D.S. and Senta-Loys, Z. and Almajaan, A. and Li, S. and Chevallier, O. and Elliot, C. and Healy, A.M. and Kelleher, J.F. and Madi, A.M. and Gilvary, G.C. and Tian, Y., The development of an inline Raman spectroscopic analysis method as a quality control tool for hot melt extruded ramipril fixed-dose combination products, International Journal of Pharmaceutics, 566, 2019, p476-487Journal Article, 2019, DOI , URL
• Andrews, G.P. and Li, S. and Almajaan, A. and Yu, T. and Martini, L. and Healy, A. and Jones, D.S., Fixed Dose Combination Formulations: Multilayered Platforms Designed for the Management of Cardiovascular Disease, Molecular Pharmaceutics, 16, (5), 2019, p1827-1838Journal Article, 2019, DOI , URL
• Pharmaceutics, Basel, Switzerland, MDPI, [eds.], 2019Editorial Board, 2019
• Kelleher J.F., Madi A.M., Gilvary G.C., Tian Y.W., Li S., Almajaan A., Loys Z.S., Jones D.S., Andrews G.P., Healy A.M., Metformin Hydrochloride and Sitagliptin Phosphate Fixed-Dose Combination Product Prepared Using Melt Granulation Continuous Processing Technology, AAPS PharmSciTech, 21, (1), 2020Journal Article, 2020, DOI , TARA - Full Text
• Mah P.T., O'Connell P., Focaroli S., Lundy R., O'Mahony T.F., Hastedt J.E., Gitlin I., Oscarson S., Fahy J.V., Healy A.M., The use of hydrophobic amino acids in protecting spray dried trehalose formulations against moisture-induced changes, European Journal of Pharmaceutics and Biopharmaceutics, 144, 2019, p139 - 153, p139-153Journal Article, 2019, DOI
• Serrano D.R., Fernandez-Garcia R., Mele M., Healy A.M., Lalatsa A., Designing fast-dissolving orodispersible films of amphotericin b for oropharyngeal candidiasis, Pharmaceutics, 11, (8), 2019Journal Article, 2019, DOI
• David Blanco, Osmo Antikainen, Heikki Räikkönen, Pei Ting Mah, Anne Marie Healy, Anne Mari Juppo, Jouko Yliruusi, Image-based characterization of powder flow to predict the success of pharmaceutical minitablet manufacturing, International Journal of Pharmaceutics, 2020, pE119280Journal Article, 2020, DOI , URL
• Jose R. Cerda, Talaya Arifi, Sejad Ayyoubi, Peter Knief, Maria Paloma Ballesteros, William Keeble, Eugen Barbu, Anne Marie Healy, Aikaterini Lalatsa, Dolores R. Serrano, Personalised 3D Printed Medicines: Optimising Material Properties for Successful Passive Diffusion Loading of Filaments for Fused Deposition Modelling of Solid Dosage Forms, Pharmaceutics, 12, (4), 2020, pE345Journal Article, 2020, DOI , URL
• Browne E., Worku Z.A., Healy A.M., Physicochemical properties of poly-vinyl polymers and their influence on ketoprofen amorphous solid dispersion performance: A polymer selection case study, Pharmaceutics, 12, (5), 2020, pE433Journal Article, 2020, DOI
• Dadou S.M., Senta-Loys Z., Almajaan A., Li S., Jones D.S., Healy A.M., Tian Y., Andrews G.P., The development and validation of a quality by design based process analytical tool for the inline quantification of Ramipril during hot-melt extrusion, International Journal of Pharmaceutics, 584, 2020Journal Article, 2020, DOI
• de Castro R.R., Todaro V., da Silva L.C.R.P., Simon A., do Carmo F.A., de Sousa V.P., Rodrigues C.R., Sarmento B., Healy A.M., Cabral L.M., Development of inhaled formulation of modified clofazimine as an alternative to treatment of tuberculosis: Clofazimine inhaled formulation for tuberculosis, Journal of Drug Delivery Science and Technology, 58, 2020Journal Article, 2020, DOI , TARA - Full Text
• Kavanagh O., Marie Healy A., Dayton F., Robinson S., O'Reilly N.J., Mahoney B., Arthur A., Walker G., Farragher J.P., Inhaled hydroxychloroquine to improve efficacy and reduce harm in the treatment of COVID-19, Medical Hypotheses, 143, 2020Journal Article, 2020, DOI
• D'Arcy DM, Corrigan OI, Healy AM, Hydrodynamic simulation (computational fluid dynamics) of asymmetrically positioned tablets in the paddle dissolution apparatus: impact on dissolution rate and variability, Journal of Pharmacy and Pharmacology, 57, 2005, p1243 - 1250Journal Article, 2005
• Focaroli S., Jiang G., O'connell P., Fahy J.V., Healy A.-M., The use of a three-fluid atomising nozzle in the production of spray-dried theophylline/salbutamol sulphate powders intended for pulmonary delivery, Pharmaceutics, 12, (11), 2020, p1 - 18, p1-18Journal Article, 2020, DOI
• Stocker M.W., Healy A.M., Ferguson S., Spray Encapsulation as a Formulation Strategy for Drug-Based Room Temperature Ionic Liquids: Exploiting Drug-Polymer Immiscibility to Enable Processing for Solid Dosage Forms, Molecular Pharmaceutics, 17, (9), 2020, p3412 - 3424, p3412-3424Journal Article, 2020, DOI
• Suzuki E.Y., Simon A., da Silva A.L., Amaro M.I., de Almeida G.S., Agra L.C., Cabral L.M., Rocco P.R.M., Healy A.M., de Sousa V.P., Effects of a novel roflumilast and formoterol fumarate dry powder inhaler formulation in experimental allergic asthma, International Journal of Pharmaceutics, 588, 2020Journal Article, 2020, DOI
• Todaro V., Healy A.M., Development and characterization of ibuprofen co-crystals granules prepared via fluidized bed granulation in a one-step process"a design of experiment approach, Drug Development and Industrial Pharmacy, 2021Journal Article, 2021, DOI
• Ayyoubi S, Cerda JR, Fernández-García R, Knief P, Lalatsa A, Marie Healy A, Serrano DR., 3D printed spherical mini-tablets: Geometry versus composition effects in controlling dissolution from personalised solid dosage forms., International journal of pharmaceutics, 2021, p120336Journal Article, 2021, DOI
• Antonio Matji, Nicoletta Donato, Adrianna Gagol, Enrique Morales, Luis Carvajal, Dolores R. Serrano, Zelalem A. Worku, Anne Marie Healy, Juan Jose Torrado, Predicting the critical quality attributes of ibuprofen tablets via modelling of process parameters for roller compaction and tabletting, International Journal of Pharmaceutics, 565, 2019, p209--218Journal Article, 2019
• Tewes F., Brillault J., Gregoire N., Olivier J.-C., Lamarche I., Adier C., Healy A.-M., Marchand S., Comparison between colistin sulfate dry powder and solution for pulmonary delivery, Pharmaceutics, 12, (6), 2020, p1 - 17, p1-17Journal Article, 2020, DOI
• Fernández-García, R. and Muñoz-García, J.C. and Wallace, M. and Fabian, L. and González-Burgos, E. and Gómez-Serranillos, M.P. and Raposo, R. and Bolás-Fernández, F. and Ballesteros, M.P. and Healy, A.M. and Khimyak, Y.Z. and Serrano, D.R., Self-assembling, supramolecular chemistry and pharmacology of amphotericin B: Poly-aggregates, oligomers and monomers, Journal of Controlled Release, 341, 2022, p716-732Journal Article, 2022, DOI , URL
• Queiroz, A.L.P. and Kerins, B.M. and Yadav, J. and Farag, F. and Faisal, W. and Crowley, M.E. and Lawrence, S.E. and Moynihan, H.A. and Healy, A.-M. and Vucen, S. and Crean, A.M., Investigating microcrystalline cellulose crystallinity using Raman spectroscopy, Cellulose, 28, (14), 2021, p8971-8985Journal Article, 2021, DOI , URL
• Browne, E. and Quinn, S. and Cheyne, S. and Healy, A.M., Design and characterisation of an amorphous formulation of nifedipine for the treatment of autonomic dysreflexia, Journal of Pharmacy and Pharmacology, 73, (7), 2021, p928-936Journal Article, 2021, DOI , URL
• Tsolaki, E. and Stocker, M.W. and Healy, A.M. and Ferguson, S., Formulation of ionic liquid APIs via spray drying processes to enable conversion into single and two-phase solid forms, International Journal of Pharmaceutics, 603, (120669), 2021Journal Article, 2021, DOI , URL
• He, Y. and Glennon, B. and Gao, Y. and Healy, A.-M. and Worku, Z., Tailoring CSD & shape of ibuprofen to improve flow properties in batch & continuous crystallization, 2017-October, 2017, pp576-585Conference Paper, 2017, URL
• He, Y. and Glennon, B. and Gao, Y. and Healy, A.-M. and Worku, Z., Tailoring csd & shape of ibuprofen to improve flow properties in batch & continuous crystallization, 2017-October, 2017, pp413-422Conference Paper, 2017, URL
• He, Y. and Glennon, B. and Gao, Y. and Healy, A.-M. and Worku, Z., Tailoring CSD & shape of ibuprofen to improve flow properties in batch & continuous crystallization, 2, 2017, pp1106-1115Conference Paper, 2017, URL
• Stocker M.W., Harding M.J., Todaro V., Healy A.M., Ferguson S., Integrated Purification and Formulation of an Active Pharmaceutical Ingredient via Agitated Bed Crystallization and Fluidized Bed Processing, Pharmaceutics, 14, (5), 2022Journal Article, 2022, DOI
• Nambiar, A.G. and Singh, M. and Mali, A.R. and Serrano, D.R. and Kumar, R. and Healy, A.M. and Agrawal, A.K. and Kumar, D., Continuous Manufacturing and Molecular Modeling of Pharmaceutical Amorphous Solid Dispersions, AAPS PharmSciTech, 23, (7), 2022Journal Article, 2022, DOI , URL
• Khanna, K. and Raymond, W.W. and Jin, J. and Charbit, A.R. and Gitlin, I. and Tang, M. and Werts, A.D. and Barrett, E.G. and Cox, J.M. and Birch, S.M. and Martinelli, R. and Sperber, H.S. and Franz, S. and Duff, T. and Hoffmann, M. and Healy, A.M. and Oscarson, S. and Pöhlmann, S. and Pillai, S.K. and Simmons, G. and Fahy, J.V., Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19, American journal of physiology. Lung cellular and molecular physiology, 323, (3), 2022, pL372-L389Journal Article, 2022, DOI , URL
• Fernández-García R, Walsh D, O'Connell P, Slowing K, Raposo R, Paloma Ballesteros M, Jiménez-Cebrián A, Chamorro-Sancho MJ, Bolás-Fernández F, Healy AM, Serrano DR., Can amphotericin B and itraconazole be co-delivered orally? Tailoring oral fixed-dose combination coated granules for systemic mycoses., European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 183, 2023, p74-91Journal Article, 2023, DOI
• Stocker MW, Tsolaki E, Harding MJ, Healy AM, Ferguson S., Combining Isolation-Free and Co-processing Manufacturing Approaches to Access Room Temperature Ionic Liquid Forms of APIs., Journal of pharmaceutical sciences, 2023, pS0022-3549(23)00052-7Journal Article, 2023, DOI
• Myslinska M, Stocker MW, Ferguson S, Healy AM., A Comparison of Spray-Drying and Co-Precipitation for the Generation of Amorphous Solid Dispersions (ASDs) of Hydrochlorothiazide and Simvastatin., Journal of pharmaceutical sciences, 2023, pS0022-3549(23)00064-3Journal Article, 2023, DOI
• de Pablo E, O'Connell P, Fernández-García R, Marchand S, Chauzy A, Tewes F, Dea-Ayuela MA, Kumar D, Bolás F, Ballesteros MP, Torrado JJ, Healy AM, Serrano DR., Targeting lung macrophages for fungal and parasitic pulmonary infections with innovative amphotericin B dry powder inhalers., International journal of pharmaceutics, 635, 2023, p122788Journal Article, 2023, DOI
• Shao S., Bonner D., Twamley B., Singh A., Healy A.M., One Step In Situ Co-Crystallization of Dapsone and Polyethylene Glycols during Fluidized Bed Granulation, Pharmaceutics, 15, (9), 2023Journal Article, 2023, DOI
• Shao S., Stocker M.W., Zarrella S., Korter T.M., Singh A., Healy A.M., In Situ Cocrystallization via Spray Drying with Polymer as a Strategy to Prevent Cocrystal Dissociation, Molecular Pharmaceutics, 20, (9), 2023, p4770 - 4785, p4770-4785Journal Article, 2023, DOI
• Salomé S. Celi, Raquel Fernández-García, Andreina I. Afonso-Urich, M. Paloma Ballesteros, Anne Marie Healy, Dolores R. Serrano, Co-Delivery of a High Dose of Amphotericin B and Itraconazole by Means of a Dry Powder Inhaler Formulation for the Treatment of Severe Fungal Pulmonary Infections, Pharmaceutics, 15, (11), 2023, p2601Journal Article, 2023
• Autzen Virtanen, A. and MyÅ liÅ"ska, M. and Healy, A.M. and Power, E. and Madi, A. and Sivén, M., The challenge of downstream processing of spray dried amorphous solid dispersions into minitablets designed for the paediatric population â€" A sustainable product development approach, European Journal of Pharmaceutical Sciences, 196, (106752), 2024Journal Article, 2024, DOI , URL
• Kara, A. and Kumar, D. and Healy, A.M. and Lalatsa, A. and Serrano, D.R., Continuous Manufacturing of Cocrystals Using 3D-Printed Microfluidic Chips Coupled with Spray Coating, Pharmaceuticals, 16, (8), 2023Journal Article, 2023, DOI , URL
• Addante, A. and Raymond, W. and Gitlin, I. and Charbit, A. and Orain, X. and Scheffler, A.W. and Kuppe, A. and Duerr, J. and Daniltchenko, M. and Drescher, M. and Graeber, S.Y. and Healy, A.-M. and Oscarson, S. and Fahy, J.V. and Mall, M.A., A novel thiol-saccharide mucolytic for the treatment of muco-obstructive lung diseases, European Respiratory Journal, 61, (5), 2023Journal Article, 2023, DOI , URL
• Andrews, G.P. and Healy, A.M. and Topp, E.M., Introducing the Molecular Pharmaceutics Special Issue on †Advances in Small and Large Molecule Pharmaceutics Research across Ireland†, Molecular Pharmaceutics, 21, (8), 2024, p3693-3694Journal Article, 2024, DOI , URL
• Piatek, M. and Grassiri, B. and O†Ferrall, L.M. and Piras, A.M. and Batoni, G. and Esin, S. and O†Connor, C. and Griffith, D. and Healy, A.M. and Kavanagh, K., Quantitative proteomic analysis reveals Ga(III) polypyridyl catecholate complexes disrupt Aspergillus fumigatus mitochondrial function, Journal of Biological Inorganic Chemistry, 2024Journal Article, 2024, DOI , URL
• Corrigan DO, Healy AM, Corrigan OI, Preparation and release of salbutamol from chitosan and chitosan co-spray dried compacts and multiparticulates, European Journal of Pharmaceutics and Biopharmaceutics, 62, (3), 2006, p295 - 305Journal Article, 2006
• D'Arcy DM, Corrigan OI, Healy AM, Evaluation of hydrodynamics in the basket dissolution apparatus using computational fluid dynamics-Dissolution rate implications., European Journal of Pharmaceutical Sciences, 27, (2-3), 2006, p259 - 267Journal Article, 2006, DOI
• Corrigan DO, Corrigan OI, Healy AM, Physicochemical and in vitro deposition properties of salbutamol sulphate/ipratropium bromide and salbutamol sulphate/excipient spray dried mixtures for use in dry powder inhalers, International Journal of Pharmaceutics, 322, (1-2), 2006, p22 - 30Journal Article, 2006, DOI
• McDonald, B.F., Tajber, L., Corrigan, O.I. and Healy, A.M., Nanoporous microparticles (NPMPs) of budesonide for pulmonary delivery, AAPS Journal, American Association of Pharmaceutical Scientists Annual Meeting, San Antonio, USA, November 2006, 8, (S2), American Association of Pharmaceutical Scientists, 2006, ppM1241Meeting Abstract, 2006, URL
• Ni Ogain, O., Tajber, L., Corrigan, O.I. and Healy, A.M., Nanoporous microparticles (NPMPs) - a novel drug delivery system for the pulmonary delivery of proteins, AAPS Journal, American Association of Pharmaceutical Scientists Annual Meeting, San Antonio, USA, November 2006, 8, (S2), American Association of Pharmaceutical Scientists, 2006, ppW5076Meeting Abstract, 2006, URL
• Healy AM, Corrigan OI, Predicting the dissolution rate of ibuprofen-excipient compressed mixtures in reactive media, International Journal of Pharmaceutics, 84, (2), 1992, p167 - 173Journal Article, 1992
• D'Arcy, D.M., Corrigan, O.I. and Healy, A.M., Use of computational fluid dynamics to model fluid flow and interpret dissolution rate data for the basket dissolution apparatus, 1st PharmSciFair, Pharmaceutical sciences Fair and Exhibition, Nice, France, 2005, ppP0292Meeting Abstract, 2005
• Tajber, L., Healy, A.M. and Corrigan, O.I., The effect of polyvinylpyrrolidone content on the glass transition temperature of thiazide diuretics, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, Germany, 2004, 2004, pp711 - 712Meeting Abstract, 2004
• Nolan, L., Tajber, L., Corrigan, O.I. and Healy, A.M., The physicochemical characterisation of spray dried nanoporous microparticles (NPMPs) of sulfa compounds, EUFEPS Conference: When Poor Solubility Becomes an Issue: From Early Stage to Proof of Principles, Verona, Italy, 26-27 April, 2006Meeting Abstract, 2006
• Tajber, L., Healy, A.M., Corrigan,O.I., Characterisation of the thermal behaviour of PVP-sulfa compound composites, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva, Switzerland, 27-30 March, 2006Meeting Abstract, 2006
• D'Arcy, D., Fagan, F., O'Neill, E., Corrigan, O.I. and Healy, A.M., Dissolution under conditions of natural convection - investigating the effect of orientation and solubility, EUFEPS Conference: When Poor Solubility Becomes an Issue: From Early Stage to Proof of Principles, Verona, Italy, 26-27 April, 2006, pp59Meeting Abstract, 2006
• D'Arcy, D.M., Corrigan, O.I., Healy, A.M., Use of Computational Fluid Dynamics (CFD) to investigate hydrodynamics involved in in vitro in vivo correlations (IVIVC) , EUFEPS/COST B 25 conference on Bioavailability (BA) and Bioequivalence (BE): Focus on physiological factors and variability., Athens, Greece, October, 2007Poster, 2007
• D'Arcy D.M., Corrigan, O.I., Healy, A.M., Investigating the hydrodynamics involved in early in vito in vivo correlations - computational fluid dynamics (CFD) simulations of hydrodynamics in the Levy beaker apparatus., PSWC 3rd World congress of the Board of Pharmaceutical Sciences of the FIP., Amsterdam, The Netherlands, April, 2007Poster, 2007
• ffrg(ed.), The physicochemical characterisation of porous sodium cromoglicate particles for inhalation, Journal of Aerosol Science, 20, (2), 2007, 168 pProceedings of a Conference, 2007
• Healy AM, McDonald BF, Tajber L, Corrigan OI, Characterisation of excipient-free nanoporous microparticles (NPMPs) of bendroflumethiazide, European Journal of Pharmaceutics and Biopharmaceutics, 69, (3), 2008, p1182 - 1186Journal Article, 2008
• Tajber L, Corrigan OI, Healy AM, Spray drying of budesonide, formoterol fumarate and their composites-II. Statistical factorial design and in vitro deposition properties, International Journal of Pharmaceutics, 367, (1-2), 2009, p86 - 96Journal Article, 2009, DOI
• Tajber L, Corrigan DO, Corrigan OI, Healy AM, Spray drying of budesonide, formoterol fumarate and their composites-I. Physicochemical characterisation, International Journal of Pharmaceutics, 367, (1-2), 2009, p79 - 85Journal Article, 2009, DOI
• Tajber L, Crean B, Roberts CJ, Nolan L, Corrigan OI, Healy AM, Budesonide Nanoporous Microparticles (NPMPs) - in vitro Aerosolisation Properties and Atomic Force Microscopy (AFM), 35th Controlled Release Society Annual Meeting & Exposition, New York, USA, 12-16, July 2008, 2008Meeting Abstract, 2008
• Paluch K, Tajber L, Healy AM, Corrigan OI, Comparison of the physico-chemical properties of spray dried chlorothiazide, chlorothiazide sodium and their PVP composite systems, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spain, 1-10, April 2008, 2008Meeting Abstract, 2008
• Katheri AK, Tajber L, Corrigan OI, Healy AM, Spray dried nanoporous microparticles of corticosteroids for dry powder oral inhalation, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spain, 1-10, April 2008, 2008Meeting Abstract, 2008
• Healy AM, McDonald B, Corrigan OI, Tajber L, 'A method of producing porous microparticles', Trinity College Dublin, US20100092453, 2009Patent, 2009, URL
• Healy AM, McDonald BF, Tajber L, Corrigan OI, Characterisation of excipient-free nanoporous microparticles (NPMPs) of bendroflumethiazide , European Journal of Pharmaceutics and Biopharmaceutics , 69, (3), 2008, p1182 - 1186Journal Article, 2008, DOI
• D'Arcy DM, Healy AM, Corrigan OI, Towards determining appropriate hydrodynamic conditions for in vitro in vivo correlations using computational fluid dynamics, European Journal of Pharmaceutical Sciences, 37, (3-4), 2009, p291 - 299Journal Article, 2009
• Nolan LM, Tajber L, McDonald BF, Barham AS, Corrigan OI, Healy AM, Excipient-free nanoporous microparticles of budesonide for pulmonary delivery, European Journal of Pharmaceutical Sciences, 37, 2009, p593 - 602Journal Article, 2009, DOI
• Paluch KJ, Tajber L, Corrigan OI, Healy AM, An investigation of the effect of spray drying from different solvents on the physicochemical properties of chlorothiazide and chlorothiazide sodium, AAPS Annual Meeting and Exposition, Los Angeles, USA, 8-12 November, 2009, 2009Meeting Abstract, 2009
• D'Arcy DM, Liu B, Bradley G, Healy AM, Corrigan OI, Hydrodynamic and species transfer simulations in the USP 4 dissolution apparatus: considerations for dissolution in a low velocity pulsing flow, Pharmaceutical Research, 27, (2), 2010, p246-58Journal Article, 2010, DOI
• Tewes F, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Development and characterisation of soluble polymeric particles for pulmonary peptide delivery, European Journal of Pharmaceutical Sciences, 41, (2), 2010, p337 - 352Journal Article, 2010, DOI , URL , TARA - Full Text
• Paluch, K.J., Tajber, L., McCabe, T., O'Brien, J.E., Corrigan, O.I., Healy, A.M., Salt or intermolecular self-assembly - physicochemical analysis of crystalline chlorothiazide and chlorothiazide sodium, All Ireland Schools of Pharmacy 32nd Research Seminar, Belfast, 2010, 2010Poster, 2010
• Paluch, K.J., Tajber, L., Corrigan, O.I., Healy, A.M., Investigation of physicochemical interactions of spray dried composites comprising polymer and chlorothiazide, chlorothiazide sodium or chlorothiazide potassium, APS Amorphous III proceedings, Nottingham, 2010, 2010Poster, 2010
• Paluch KJ, Tajber L, McCabe T, O'Brien JE, Corrigan OI, Healy AM, Preparation and solid state characterisation of chlorothiazide sodium intermolecular self assembly suprastructure, European Journal of Pharmaceutical Sciences, 41, (5), 2010, p603 - 611Journal Article, 2010, DOI , URL , TARA - Full Text
• Hao HX, Su WY, Barrett M, Caron V, Healy AM, Glennon B, A calibration-free application of Raman spectroscopy to the monitoring of mannitol crystallization and its polymorphic transformation, Organic Process Research & Development, 14, 2010, p1209 - 1214Journal Article, 2010
• Paluch KJ, Tajber L, McCabe T, O'Brien JE, Corrigan O, Healy AM, Preparation and characterisation of novel chlorothiazide potassium solid-state salt forms: intermolecular self assembly suprastructures, European Journal of Pharmaceutical Sciences, 42, (3), 2011, p220 - 229Journal Article, 2011, DOI , URL , TARA - Full Text
• Ní Ógáin O, Li J, Tajber L, Corrigan OI, Healy AM, Particle engineering of materials for oral inhalation by dry powder inhalers. I - Particles of sugar excipients (trehalose and raffinose) for protein delivery, International Journal of Pharmaceutics, 405, (1-2), 2011, p23 - 35Journal Article, 2011, DOI , URL , TARA - Full Text
• Nolan LM, Li J, Tajber L, Corrigan OI, Healy AM, Particle engineering of materials for oral inhalation by dry powder inhalers. II - Sodium cromoglicate, International Journal of Pharmaceutics, 405, (1-2), 2011, p36 - 46Journal Article, 2011, DOI , URL , TARA - Full Text
• Caron V, Tajber L, Corrigan OI, Healy AM, A comparison of spray drying and milling in the production of amorphous dispersions of sulfathiazole/polyvinylpyrrolidone and sulfadimidine/polyvinylpyrrolidone, Molecular Pharmaceutics, 8, (2), 2011, p532 - 542Journal Article, 2011, DOI
• Amaro MI, Tajber, L, Corrigan OI, Healy AM, Design of experiment to study the effect of spray dryer operating variables on sugar powders intended for inhalation, Journal of Pharmacy and Pharmacology, UK-PharmSci 2010, Nottingham, UK, 62, (10 Sp. Iss.), 2010, pp1413 - 1414Conference Paper, 2010
• Paluch K, Tajber L, Elcoate CJ, Corrigan OI, Lawrence SE, Healy AM, Solid state characterisation of novel active pharmaceutical ingredients: co-crystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt, Journal of Pharmaceutical Sciences, 100, (8), 2011, p3268 - 3283Journal Article, 2011, DOI , URL , TARA - Full Text
• Baginski L, Tewes F, Buckley ST, Healy AM, Bakowsky U, Ehrhardt C, Investigations on the fate of inhaled salmon calcitonin at the respiratory epithelial barrier, Pharmaceutical Research, 29, (1), 2012, p332-341Journal Article, 2012, DOI
• Amaro MI, Tajber L, Corrigan OI, Healy AM, Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation, International Journal of Pharmaceutics, 421, (1), 2011, p99 - 109Journal Article, 2011, DOI , URL , TARA - Full Text
• Grossjohann C, Eccles KS, Maguire AR, Lawrence SE, Tajber L, Corrigan OI, Healy AM, Characterisation, solubility and intrinsic dissolution behaviour of benzamide:dibenzyl sulfoxide cocrystal, International Journal of Pharmaceutics, 422, (1-2), 2012, p24-32Journal Article, 2012, DOI , URL , TARA - Full Text
• Baginski L, Gobbo OL, Tewes F, Salomon JJ, Healy AM, Bakowsky U, Ehrhardt C, In vitro and in vivo characterisation of PEG-lipid based micellar complexes of salmon calcitonin for pulmonary delivery, Pharm Res, 29, (6), 2012, p1425-1434Journal Article, 2012, DOI
• Tewes F, Gobbo OL, Amaro MI, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Evaluation of HPβCD-PEG microparticles for salmon calcitonin administration via pulmonary delivery, Molecular Pharmaceutics, 8, (5), 2011, p1887 - 1898Journal Article, 2011, DOI
• Gad S, Tajber L, Corrigan OI Healy AM, Preparation and characterisation of novel spray dried nano-structured para-aminosalicylic acid particulates for pulmonary delivery: impact of ammonium carbonate on morphology, chemical composition and solid state, Journal of Pharmacy and Pharmacology, 64, (9), 2012, p1264 - 1274Journal Article, 2012, DOI , TARA - Full Text
• Ní Ógáin O, Tajber L, Corrigan OI, Healy AM, Spray drying from organic solvents to prepare nanoporous/nanoparticulate microparticles (NPMPs) of protein:excipient composites designed for oral inhalation, Journal of Pharmacy and Pharmacology, 64, (9), 2012, p1275 - 1290Journal Article, 2012, DOI , TARA - Full Text
• Bianco S, Caron V, Tajber L, Corrigan OI, Nolan LM, Hu Y, Healy AM, Modification of the solid state nature of sulfathiazole and sulfathiazole sodium by spray drying, AAPS PharmSciTech, 13, (2), 2012, p647 - 660Journal Article, 2012, DOI
• Paluch KJ, Tajber L, Corrigan OI, Healy AM, Impact of process variables on the micromeritic and physicochemical properties of spray dried porous microparticles - Part I. Introduction of a new Morphology Classification System, Journal of Pharmacy and Pharmacology, 64, (11), 2012, p1570 - 1582Journal Article, 2012, DOI , TARA - Full Text
• Paluch KJ, Amaro MI, Tajber L, Corrigan OI, Healy AM, Impact of process variables on the micromeritic and physicochemical properties of spray dried microparticles - Part II. Physicochemical characterisation of spray dried materials, Journal of Pharmacy and Pharmacology, 64, (11), 2012, p1583 - 1591Journal Article, 2012, DOI , TARA - Full Text
• Paluch KJ, Tajber L, Adamczyk B, Corrigan OI, Healy AM, A novel approach to crystallisation of nanodispersible microparticles by spray drying for improved tabletability, International Journal of Pharmaceutics, 436, (1-2), 2012, p873 - 876Journal Article, 2012, DOI , URL
• Hu Y, MacFhionnghaile P, Caron V, Tajber L, Healy AM, Erxleben A, Formation, physical stability and quantification of process induced disorder in cryo-milled samples of a model polymorphic drug, Journal of Pharmaceutical Sciences, 102, (1), 2013, p93 - 103Journal Article, 2013, DOI
• Tewes F, Paluch KJ, Tajber L, Gulati K, Kalantri D, Ehrhardt C, Healy AM, Steroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery, European Journal of Pharmaceutics and Biopharmaceutics, 85, (3), 2013, p604 - 613Journal Article, 2013, DOI , TARA - Full Text
• Swaminathan J, Gobbo OL, Tewes F, Healy AM, Ehrhardt C, Encapsulation into PEG-liposomes does not improve the bioavailability of pulmonary delivered salmon calcitonin, Journal of Aerosol Medicine and Pulmonary Drug Delivery, 27, (1), 2014, p1-11Journal Article, 2014, DOI
• Caron V, Hu Y, Tajber L, Erxleben A, Corrigan OI, McArdle P, Healy AM, Amorphous solid dispersions of sulfonamide/Soluplus® and sulfonamide/PVP prepared by ball milling, AAPS PharmSciTech, 14, (1), 2013, p464-474Journal Article, 2013, DOI , TARA - Full Text
• Curtin V, Amharar Y, Hu Y, Erxleben A, McArdle P, Caron V, Tajber L, Corrigan OI, Healy AM, Investigation of the capacity of low glass transition temperature excipients to minimize amorphization of sulfadimidine on comilling, Molecular Pharmaceutics , 10, (1), 2013, p386-396Journal Article, 2013, DOI
• Paluch KJ, McCabe T, Müller-Bunz H, Corrigan OI, Healy AM, Tajber L, Formation and physicochemical properties of crystalline and amorphous salts with different stoichiometries formed between ciprofloxacin and succinic acid, Molecular Pharmaceutics, 10, (10), 2013, p3640 - 3654Journal Article, 2013, DOI , TARA - Full Text
• Bianco S, Tewes F, Tajber L, Caron V, Corrigan OI, Healy AM, Bulk, surface properties and water uptake mechanisms of salt/acid amorphous composite systems, International Journal of Pharmaceutics, 456, (1), 2013, p143 - 152Journal Article, 2013, DOI , TARA - Full Text
• Paluch KJ, Tajber L, Corrigan OI, Healy AM, Impact of alternative solid state forms and specific surface area of high-dose, hydrophilic active pharmaceutical ingredients on tabletability, Molecular Pharmaceutics, 10, (10), 2013, p3628 - 3639Journal Article, 2013, URL
• Curtin V, Amharar Y, Gallagher KH, Corcoran S, Tajber L, Corrigan OI, Healy AM, Reducing mechanical activation-induced amorphisation of salbutamol sulphate by co-processing with selected carboxylic acids, International Journal of Pharmaceutics, 456, (2), 2013, p508 - 516Journal Article, 2013, DOI , TARA - Full Text
• Barham AS, Tewes F, Healy AM, Moisture diffusion and permeability characteristics of hydroxypropylmethylcellulose and hard gelatin capsules., International journal of pharmaceutics, 478, (2), 2015, p796-803Journal Article, 2015, DOI , TARA - Full Text
• Holmes MS, Seheult JN, O'Connell P, D'Arcy S, Ehrhardt C, Healy AM, Costello RW, Reilly RB, An acoustic-based method to detect and quantify the effect of exhalation into a dry powder inhaler., Journal of aerosol medicine and pulmonary drug delivery, 28, (4), 2015, p247 - 253Journal Article, 2015, DOI
• Amaro MI, Tajber L, Corrigan OI, Healy AM, Co-spray dried carbohydrate microparticles: crystallisation delay/inhibition and improved aerosolization characteristics through the incorporation of hydroxypropyl-ß-cyclodextrin with amorphous raffinose or trehalose, Pharmaceutical Research, 32, (1), 2015, p180 - 195Journal Article, 2015, DOI , TARA - Full Text
• Amharar Y, Curtin V, Gallagher KH, Healy AM, Solubility of crystalline organic compounds in high and low molecular weight amorphous matrices above and below the glass transition by zero enthalpy extrapolation, International journal of pharmaceutics, 472, (1-2), 2014, p241-7Journal Article, 2014, DOI , TARA - Full Text
• Seheult JN, O'Connell P, Tee KC, Bholah T, Al Bannai H, Sulaiman I, MacHale E, D'Arcy S, Holmes MS, Bergin D, Reeves E, Reilly RB, Crispino-O'Connell G, Ehrhardt C, Healy AM, Costello RW, The acoustic features of inhalation can be used to quantify aerosol delivery from a Diskus" dry powder inhaler, Pharmaceutical research, 31, (10), 2014, p2735-47Journal Article, 2014, DOI , TARA - Full Text
• Healy AM, Amaro MI, Paluch KJ, Tajber L, Dry powders for oral inhalation free of lactose carrier particles, Advanced Drug Delivery Reviews, 75, 2014, p32 - 52Review Article, 2014, DOI , TARA - Full Text
• Tian Y, Caron V, Jones DS, Healy AM, Andrews GP, Using Flory-Huggins phase diagrams as a pre-formulation tool for the production of amorphous solid dispersions: a comparison between hot-melt extrusion and spray drying, The Journal of pharmacy and pharmacology, 66, (2), 2014, p256-74Journal Article, 2014, DOI
• Tewes F, Ehrhardt C, Healy AM, Superparamagnetic iron oxide nanoparticles (SPIONs)-loaded Trojan microparticles for targeted aerosol delivery to the lung, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, 86, (1), 2014, p98-104Journal Article, 2014, DOI , TARA - Full Text
• Tao Z, Paluch K, Scalabrino G, Frankish N, Healy AM, Sheridan H, Molecular structure studies of (1S,2S)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol, Journal of Molecular Structure, 2015, p286 - 299Journal Article, 2015, URL , TARA - Full Text
• Grossjohann C, Serrano DR, Paluch KJ, O'Connell P, Vella-Zarb L, Manesiotis P, McCabe T, Tajber L, Corrigan OI, Healy AM, Polymorphism in sulfadimidine/4-aminosalicylic acid cocrystals: solid state characterization and physicochemical properties, Journal of Pharmaceutical Sciences, 104, (4), 2015, p1385-13Journal Article, 2015, DOI , TARA - Full Text

• D'Arcy, D.M., Corrigan, O.I. and Healy, A.M., Dissolution modelling of off-centre compacts in the paddle dissolution apparatus, Schools of Pharmacy Research Seminar, Trinity College Dublin, 21st to 22nd March, 2005, pp33 (abstract)Conference Paper
• Healy, A.M., Parojčić, J., Srcic, S., Juppo, A., Andrews, G., McSweeney, N, Glennon, B., Lu trik, M, Jones, I. Milne, J. Corrigan, B. Kinahan, M., Tully, R. , Linking industry and academia in teaching pharmaceutical development and manufacture (LIAT-Ph), European Industrial Pharmacy, 21, 2014, p9 - 10Journal Article
• Healy, A.M., Linking Industry and Academe. A case study, FORUM, Spring , 2014, p38-Journal Article
• Healy, A.M., Particle formation processes for pharmaceuticals, Irish Chemical News, 16, (2), 2002, p6 - 11Journal Article
• Crean, A.M., Healy, A.M., Changing concepts for 21st Century Drug Product Manufacturing, UK and Ireland Controlled Release Society (UKICRS) Newsletter , 2011, - 4-5Miscellaneous
• Test, Test, 2021Report
• Paluch, K., Tajber, L., Healy, A.M. and Corrigan, O.I., Solid-state characteristics of spray dried chlorothiazide, chlorothiazide-PVP composites, sodium chlorothiazide and sodium chlorothiazide-PVP composites, All Ireland Schools of Pharmacy 30th Research Seminar, Cork, 2008, 2008Meeting Abstract
• Paluch K., Tajber L., Healy A.M., Corrigan O. , Impact of solvent variable on chlorothiazide and chlorothiazide sodium physico-chemical properties, processed by spray drying, All Ireland Schools of Pharmacy 31st Research Seminar, Dublin, 2009, 2009Meeting Abstract
• Paluch K, Tajber L, Corrigan OI, Healy AM, An investigation of the effect of spray drying from different solvents on the physicochemical properties of chlorothiazide and chlorothiazide sodium, IRCSET Symposium Innovation fuelling the Smart Society, Dublin, 2009, 2009Poster
• Paluch, K.J., Tajber, L., Corrigan, O.I., Healy, A.M., Solid state characterisation of novel active pharmaceutical ingredients: co-crystal of (R,S) salbutamol mono-adipate and (R,S) salbutamol hemisuccinate, Solid State Pharmaceutical Cluster Meeting, Limerick, 2010, 2010Poster
• F Tewes, L Tajber, C Ehrhardt, AM Healy, Formulation of colistin-ambroxol microparticles for passive targeting of lung infections, AAPS J, 25th Annual Meeting of the AAPS, Washington, DC, 23-27/11/2011, 13, (S2), 2011, ppM1046Meeting Abstract

• Title

  Advanced Materials & Bioengineering Research Centre (AMBER) - The development of microparticle-based solid dosage forms for the prevention and treatment of iron deficiency
  Summary

  The goal of this project is to design and develop a tabletted formulation based on iron-loaded microparticles for prevention and treatment of iron deficiency.
  Funding Agency

  Science Foundation Ireland / Solvotrin Therapeutics
  Date From

  11/08/2014
  Date To

  31/05/2019
• Title

  Synthesis & Solid State Pharmaceutical Centre (SSPC)-PharM5
  Summary
  Funding Agency

  Science Foundation Ireland
  Date From

  01/06/2019
  Date To

  31/05/2025
• Title

  Synthesis and Solid State Pharmaceutical Centre - Drug Product Formulation and Manufacture Strand projects
  Summary

  The goal of the SSPC research programme is to gain a better understanding of mechanisms, control processes and predicting outcomes for the efficient and environmentally sustainable production of safe medicines. Specific projects being managed by AMH: Identification and control of critical API characteristics for robust drug product performance; Tailoring crystal size distributions for improved formulation performance; Advancing conventional solid dosage formulation and processing for crystalline API; Amorphous solids and composites.
  Funding Agency

  Science Foundation Ireland
  Date From

  01/06/2013
  Date To

  31/05/2019
• Title

  Approaches to Drying Hydrated Active Pharmaceutical Ingredients (APIs)
  Summary

  In this project we will study the impact of drying conditions on the crystal form of the API and develop possible strategies to ensure the form is correctly managed during small scale and then large-scale drying operations.
  Funding Agency

  Irish Research Council/APC Ltd.
  Date From

  01/10/2018
  Date To

  30/09/2022
• Title

  Mechanism of Mucus Pathology in Asthma Exacerbations
  Summary

  This project aims to advance understanding of mucus pathology in acute severe asthma and to hasten a new drug development program for thiol-saccharides as a novel mucolytic treatment for mucus pathology in acute asthma.
  Funding Agency

  National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI)
  Date From

  01/04/2016
  Date To

  31/03/2021
• Title

  The Development of Novel, Age-appropriate Oral Liquid Formulations to Meet Unmet Needs of Paediatric Patients
  Summary

  The goal of this project is to develop age-appropriate liquid formulations of two active pharmaceutical ingredients, which will address unmet patient needs.
  Funding Agency

  Irish Research Council/Xeolas Ltd.
  Date From

  01/01/2017
  Date To

  31/12/2020
• Title

  Development of Fixed Dose Combination Products using Advanced Pharmaceutical Processing Technologies
  Summary

  The goal of this project is to develop novel fixed dose combination products using continuous pharmaceutical processes, thus addressing the issue of poor patient compliance, which is frequently associated with the long term and multiple dosage regimes, typical of CVD or diabetes.
  Funding Agency

  Science Foundation Ireland / Department for the Economy (Northern Ireland)
  Date From

  01/09/2015
  Date To

  31/08/2019
• Title

  EPSRC-SFI Centre for Doctoral Training in Transformative Pharmaceutical Technologies
  Summary
  Funding Agency

  Science Foundation Ireland
  Date From

  01/09/2019
  Date To

  31/08/2027
• Title

  Carbohydrate-based Therapy for Lung Disease
  Summary

  The goal of this project is to translate our discovery of an unsuspected mechanism of mucus pathology into a mucolytic drug strategy that could benefit millions of patients with mucus-associated lung disease.
  Funding Agency

  National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI)
  Date From

  01/07/2016
  Date To

  30/06/2021

Condensed matter physics, Chemical Sciences, Pharmacology and pharmaceutical sciences,

• University of Dublin, Trinity College Non-Foundation Scholarship 1987
• Fellowship of Trinity College Dublin 2010
• Pharma Industry Awards, Pharma Research Centre of the Year - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader] 2016
• Special Visiting Researcher Fellowship - awarded by CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil) 2014
• Pharma Industry Awards, Pharma Research Centre of the Year - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader] 2015
• Pharmaceutical Society of Ireland Gold Medal 1989
• Mendell Award for Scientific Excellence (at the 13th International Conference on Pharmaceutical Technology, Strasbourg, France) 1994
• Pharma Industry Awards, Partnership Alliance of the Year - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader] 2014
• Jim Hegarty Memorial Prize in Pharmaceutical Chemistry 1989
• Pharma Industry Awards, Research & Development Achievement Award - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader] 2015

• Member of the Pharmaceutical Society of Ireland date
• Member of AAPS (American Association of Pharmaceutical Scientists) date
• Member of the Academy of Pharmaceutical Scientists (UK) date
• Member of Pharmacists in Industry, Education and Regulatory (PIER) date

• Member of the Accreditation Committee of the Pharmaceutical Society of Ireland established to review new School of Pharmacy courses in RCSI and UCC 2000-2004
• Judge for the national secondary school competition: Debating Science Issues (DSI) 2015
• Hospital Professional Awards judging panel member 2017
• Grant reviewer for the Biotechnology and Biological Sciences Research Council (BBSRC), UK 2018
• Co-PI, Strand Leader and Member of Management Committee of the Solid State Pharmaceutical Cluster 2007-2013
• Grant Reviewer for The Netherlands Organisation for Scientific Research (NWO) 2018
• External Examiner for the Pharmaceutical Society of Ireland to the Professional Registration Examination 2011-2013
• External Examiner to University of Bradford: MSc in Pharmaceutical Technology 2015-2018
• Member of assessment/interview panel to fill lecturing post in the Department of Chemical and Bioprocess Engineering in UCD 2004
• Co-PI, Strand Leader and Member of Management Committee of the Synthesis and Solid State Pharmaceutical Centre 2013-date
• Treasurer of the Irish Platform for Patient Organisations, Science & Industry (IPPOSI) 2018
• Member of the Accreditation Panel for the PSI Statutory Visit to the level 8 BPharm Degree Course at University College Cork 2013
• Honorary Treasurer and Chairperson (elected) of the Finance Committee of the Pharmaceutical Society of Ireland 2003-2006
• External Examiner to Carlow Institute of Technology, Department of Science and Health: Higher Certificate in Science - Pharmacy Technician Studies 2009-2012
• Regular reviewer for scientific journals (16) in the areas of Pharmaceutical Sciences 1995-date
• Member of interview panel for General Manager of Synthesis and Solid State Pharmaceutical Centre, UL 2013
• Grant reviewer for the Austrian Science Fund (FWF) 2016
• Member of the Implementation Steering Group for the Five-Year Integrated Pharmacy Programme 2014-2015
• Member of the Board of the Irish Platform for Patient Organisations, Science & Industry (IPPOSI) 2017-date
• External examiner for PhD candidates in: University College London (x1), University of Helsonki (x1), Queen's University Belfast School of Pharmacy (x5), University of Nottingham School of Pharmacy (x1), University of Bradford School of Pharmacy (x1), the Royal College of Surgeons in Ireland School of Pharmacy (x1), University College Dublin School of Chemical and Bioprocess Engineering (x2), The Islamia University of Bahawalpur-Pakistan school of Pharmacy (x2) 2005-date
• Co-ordinator of the EU-funded Erasmus Lifelong Learning Programme Project: Linking Industry and Academia in Pharmaceutical Development and Manufacture (LIAT-Ph) 2013-2015
• Member (elected) of the Council of the Pharmaceutical Society of Ireland 1997-2006
• Member of the Strategy Group of the Pharmaceutical Society of Ireland 2000
• Member of interview panel for Chief Pharmacist position, Department of Health 2013
• Member of the Editorial Advisory Board of Molecular Pharmaceutics 2013-date
• External Examiner to Dublin Institute of Technology, School of Chemical and Pharmaceutical Sciences: MSc in Pharmaceutical Quality Assurance & Regulation; MSc in Pharmaceutical Quality Assurance & Biotechnology 2009-2012
• Member of assessment/interview panel to fill lecturing post in the Department of Chemical and Bioprocess Engineering in UCD 2010
• External Examiner to Griffith College Dublin: MSc in Pharmaceutical Business and Technology 2016-date
• Expert consultant/witness for US based pharmaceutical company in patent related litigation case 2016
• Member of the Pharmaceutical Society of Ireland's Steering Group for the Pharmacy Education and Accreditation Reviews (PEARs) project 2008-2010
• Adjunct Experiential Instructor, St Louis College of Pharmacy 2016-date
• Grant reviewer for the Engineering and Physical Sciences Research Council (EPSRC), UK 2015
• Grant reviewer for Fundação para a Ciência e a Tecnologia, I.P. (FCT) - Portuguese public funding agency for R&D 2012-2016
• Expert consultant/witness for Irish based pharmaceutical company in patent related litigation case 2016
• Enterprise Ireland Grant Reviewer 2005-2007
• Consultant to a number of pharmaceutical companies 2000-date
• External Examiner to Hibernia College: MSc in Pharmaceutical Medicine 2012-date
• Committee member and Mentor for WiSSPC (Women in the Synthesis and Solid State Pharmaceutical Centre) 2017-date
• Invited Scientific Advisory Board Member, Alkermes Ltd. 2013-2016
• Invited Medical and Scientific Advisory Board Member, Solvotrin Therapeutics Ltd. 2014-date
• Irish Pharmacy Awards judging panel member 2016
• Member of the Board of Directors/Board of Management of Kenlis Publications Ltd., publisher of the Irish Pharmacy Journal 1999-2007
• Member of the Schools Committee of the Pharmaceutical Society of Ireland 1997-2006
• Member of the National Pharmacy Forum 2013-2014
• External Examiner to Dublin Institute of Technology, School of Food Science and Environmental Health: Higher Certificate in Pharmacy Technician Studies 2012-2015
• Member of the Curriculum Development Sub-forum of the National Pharmacy Forum 2011-2013
• Member of the Validation Panel for the BSc (Ordinary) Validation of Medicinal Products at Dublin Institute of Technology, School of Chemical and Pharmaceutical Sciences 2006
• Member of the Editorial Advisory Board of Pharmaceutical Technology Europe 2005-date