The School of Pharmacy and Pharmaceutical Sciences

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Panoz Institute
Trinity College Dublin
The University of Dublin
Dublin 2
Ireland
D02PN40

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pharmacy@tcd.ie
Dr. Astrid Sasse

Dr. Astrid Sasse

Associate Professor, Pharmacy

Associate Professor, Trinity Inst. of Neurosciences (TCIN)

3531896 2797http://healthsciences.tcd.ie/pls/pharmacy/staff.detail?uname=sassea

Biography

Dr. Sasse is a certified pharmacist who obtained her PhD in Pharmaceutical Chemistry from the Free University Berlin, Germany. She conducted post-doctoral studies funded by a Marie-Curie Fellowship (FP5) at INSERM in Paris, France on the identification of a human histamine H3 receptor subtype and genetic linkage of SNPs on histamine H3 and H4 receptors to schizophrenia. As a senior staff scientist at the Max-Planck Institute for Experimental Medicine in Goettingen, Germany she determined corticotropin-releasing factor receptor binding by ex vivo autoradiography, before joining the International Center for Neurotherapeutics (ICNT) at DCU in 2004 where she was involved in the development of neurotoxins derived from botulinum toxin by protein engineering methods. In October 2008, she was appointed as Lecturer in Pharmaceutical Chemistry at the School of Pharmacy and Pharmaceutical Sciences at TCD. Her research is focused on the development of small ligands for G-Protein coupled receptors (e.g., histamine H3/H4 receptor), and the identification, localization, and pharmacological characterization of new receptor subtypes, as well as the genetic linkage of those receptors to psychiatric disorders. She also has a special interest in alternative approaches to health, especially yoga and aromatherapy.

Publications and Further Research Outputs

  • Dul M, Paluch KJ, Kelly H, Healy AM, Sasse A, Tajber L, Self-assembled carrageenan/protamine polyelectrolyte nanoplexes-Investigation of critical parameters governing their formation and characteristics., Carbohydrate Polymers, 123, 2015, p339 - 349Journal Article, 2015, DOI , TARA - Full Text
  • Wicek, M., Kiec-Kononowicz, K., Sasse, A., Ligneau, X., Schwartz, J.-C., Schunack, W., Stark, H., Histamine receptor expression: Impact of lipophilicity on the pharmacological properties of histamine H3-receptor antagonists of the cycloalkyl carbamate class, 51, (SUPPL.1), 2002Journal Article, 2002
  • Morini, G., Grandi, D., Sasse, A., Stark, H., Schunack, W., Gastroprotective activity of the novel histamine H3-receptor agonist FUB 407, 50, (SUPPL. 2), 2001Journal Article, 2001
  • Schwartz, J.C., Morisset, S., Rouleau, A., Tardivel-Lacombe, J., Gbahou, F., Ligneau, X., Héron, A., Sasse, A., Stark, H., Schunack, W., Ganellin, R.C., Arrang, J.M., Application of genomics to drug design: The example of the histamine H3 receptor, 11, (6), 2001, p441-448Journal Article, 2001
  • Genetic Polymorphisms in the Histamine Receptor Family in, editor(s)Patrizio Blandina and Maria Beatrice Passani , Histamine Receptors - Preclinical and Clinical Aspects, Switzerland, Humana Press, Springer Nature, 2016, pp51 - 74, [Micallef, S and Sasse, A]Book Chapter, 2016, DOI , TARA - Full Text
  • Erick Motta, Marivane Lemos, Juliana C Costa, PhD. Vilmar C Banderó-Filho.; Astrid Sasse, Helen Sheridan, Jairo K Bastos, , Galloylquinic acid derivatives from Copaifera langsdorffii leaves display gastroprotective activity, Chemico-Biological Interactions, 261, 2017, p145 - 155Journal Article, 2017, DOI
  • Dul M, Paluch KJ, Healy AM, Sasse A, Tajber L, Optimisation of the self-assembly process: production of stable, alginate-based polyelectrolyte nanocomplexes with protamine, Journal of Nanoparticle Research, 19, (6), 2017, p221 - 231Journal Article, 2017, DOI , TARA - Full Text
  • Fiona Shannon, Astrid Sasse, Helen Sheridan and Michael Heinrich , Are identities oral? Understanding ethnobotanical knowledge after Irish independence (1937-1939), Journal of Ethnobiology and Ethnomedicine, 13, 2017, p65-Journal Article, 2017, DOI , URL , TARA - Full Text
  • Eissa N, Al-Houqani M, Sadeq A, Ojha SK, Sasse A, Sadek B., Current Enlightenment About Etiology and Pharmacological Treatment of Autism Spectrum Disorder., Frontiers in neuroscience, 12, 2018, p304Journal Article, 2018, DOI
  • Methodologies to identify and analyze genetic polymorphisms for human histamine receptors in, editor(s)Ekaterini Tiligada, Madeleine Ennis , Histamine Receptors as Drug Targets, Humana Press, Springer Nature, 2017, pp1 - 18, [Stephany Micallef, Astrid Sasse]Book Chapter, 2017
  • Traditional chinese medicine from aqueous extracts to therapeutic formulae in, editor(s)Aman Dekebo ed. , Plant Extracts, London UK, IntechOpen, 2019, pp1-30 , [JinFan Wang, Astrid Sasse, Helen Sheridan]Book Chapter, 2019, DOI , TARA - Full Text
  • Ryan, T.J.; Grimes, T.; Henman, M.C.; Sheachnasaigh, E.N.; O'Dwyer, M.; Roche, C.; Ryder, S.A.; Sasse, A.; Walsh, J.J. & D'Arcy, D.M, Design and Implementation of an Integrated Competency-Focused Pharmacy Programme: A Case Report., Pharmacy, 7, (3), 2019, pdoi.org/10.3390/pharmacy703012Journal Article, 2019, DOI
  • Aaron Koay, Fiona Shannon McLoone, Astrid Sasse, Michael Heinrich and Helen Sheridan, Exploring the Irish National Folklore ethnography database (Duchas.ie) for open data research on Traditional Medicine use in post-famine Ireland. An early example of Citizen Science, Frontiers in Pharmacology-Ethnopharmacology, 2020Journal Article, 2020, DOI , URL , TARA - Full Text
  • Guilherme Venâncio Símaro, Marivane Lemos, Jonas Joaquim Mangabeira da Silva, Wilson Roberto Cunha, Luiza Junqueira Carneiro, Sérgio Ricardo Ambrósio, Nayanne Larissa Cunha, Sérgio Faloni de Andrade, Caroline Arruda, Vilmar C Banderó-Filho, Astrid Sasse, Helen Sheridan, Jairo Kenupp Bastos, Márcio Luis Andrade e Silva, In vivo study of anti-inflammatory and antinociceptive activities of Copaifera pubiflora Benth oleoresin, Natural Product Research, 2020, p1 - 13Journal Article, 2020, DOI , URL
  • Guilherme Venâncio Símaro, Marivane Lemos [ ..], Helen Sheridan, Márcio Luis Andrade e Silva, Jairo Kenupp Bastos., Antinociceptive and anti-inflammatory activities of Copaifera pubiflora Benth oleoresin and its major metabolite ent-hardwickiic acid, Journal of Ethnopharmacology, 2021Journal Article, 2021, DOI
  • Eissa N, Sadeq A, Sasse A and Sadek B , Role of Spectrum Disorder and the Emergence of Brain Histaminergic System. Lessons Also for BPSD? , Frontiers in Pharmacology, 11, 2020, p886-Journal Article, 2020, DOI , URL , TARA - Full Text
  • Guilherme Venâncio Símaro, Marivane Lemos, Jonas Joaquim Mangabeira da Silva, Wilson Roberto Cunha, Luiza Junqueira Carneiro, Sérgio Ricardo Ambrósio, Nayanne Larissa Cunha, Sérgio Faloni de Andrade, Caroline Arruda, Vilmar C Banderó-Filho, Astrid Sasse, Helen Sheridan, Jairo Kenupp Bastos, Márcio Luis Andrade e Silva, In vivo study of anti-inflammatory and antinociceptive activities of Copaifera pubiflora Benth oleoresin, Natural Product Research, 36, (4), 2022, p1129 - 1133Journal Article, 2022, URL
  • Wang J, Dempsey E, Corr SC, Kukula-Koch W, Sasse A, Sheridan H., The Traditional Chinese Medicine Houttuynia cordata Thunb decoction alters intestinal barrier function via an EGFR dependent MAPK (ERK1/2) signalling pathway, Phytomedicine , 105, 2022, p154353-Journal Article, 2022, DOI , URL
  • Jinfan Wang, Sinead Corr, Astrid Sasse, Helen Sheridan, Scientific evaluation of traditional chinese medicine (TCD) Houttuynia cordata Thunb (Yu xing Tao) A case study., Planta Medica, 69th Internatinal Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Bonn, Germany, Sept. 6-8 2021, Thieme, 2021Published Abstract, 2021
  • Wang Jinfan; Sasse Astrid; Sheridan Helen, A scientific evaluation of Traditional Chinese Medicine (TCM) Houttuynia cordata Thunb (Yu xing cao): a case study., Planta Med, 87, (15), 2021, pPC8-35-Journal Article, 2021, DOI , URL
  • F Hedigan, H Sheridan, A Sasse, Benefit of inhalation aromatherapy as a complementary treatment for stress and anxiety in a clinical setting - A systematic review, Complementary Therapies in Clinical Practice, 52, 2023, p101750-Journal Article, 2023, DOI , TARA - Full Text
  • Hedigan F, Sagheri D, Sheridan H, Sasse A, Investigation of the Impact of Inhalation Aromatherapy on Relaxation and Wellbeing in a Young Adult Population, Current Research in Complementary & Alternative Medicine, 8, (2), 2024, p254-Journal Article, 2024, DOI , TARA - Full Text
  • Sasse, A, Ligneau, X, Rouleau, A, Elz, S, Ganellin, CR, Arrang, JM, Schwartz, JC, Schunack, W, Stark, H, Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties., Journal of medicinal chemistry, 45, (18), 2002Journal Article, 2002
  • Kiec-Kononowicz, K, Wiecek, M, Sasse, A, Ligneau, X, Elz, S, Ganellin, CR, Schwartz, JC, Stark, H, Schunack, W, Importance of the lipophilic group in carbamates having histamine H3-receptor antagonist activity., Die Pharmazie, 55, (5), 2000Journal Article, 2000
  • Nickel, T, Bauer, U, Schlicker, E, Kathmann, M, Göthert, M, Sasse, A, Stark, H, Schunack, W, Novel histamine H(3)-receptor antagonists and partial agonists with a non-aminergic structure., British journal of pharmacology, 132, (8), 2001Journal Article, 2001, DOI
  • Sasse, A, Ligneau, X, Sadek, B, Elz, S, Pertz, HH, Ganellin, CR, Arrang, JM, Schwartz, JC, Schunack, W, Stark, H, Benzophenone derivatives and related compounds as potent histamine H3-receptor antagonists and potential PET/SPECT ligands., Archiv der Pharmazie, 334, (2), 2001Journal Article, 2001
  • Sasse, A, Schunack, W, Stark, H, Separation of chiral 4-substituted imidazole derivatives by cyclodextrin-modified capillary electrophoresis., Biomedical chromatography : BMC, 15, (1), 2001Journal Article, 2001, DOI
  • Sasse, A, Sadek, B, Ligneau, X, Elz, S, Pertz, HH, Luger, P, Ganellin, CR, Arrang, JM, Schwartz, JC, Schunack, W, Stark, H, New histamine H(3)-receptor ligands of the proxifan series: imoproxifan and other selective antagonists with high oral in vivo potency., Journal of medicinal chemistry, 43, (17), 2000Journal Article, 2000
  • Sasse, A, Stark, H, Ligneau, X, Elz, S, Reidemeister, S, Ganellin, CR, Schwartz, JC, Schunack, W, (Partial) agonist/antagonist properties of novel diarylalkyl carbamates on histamine H3 receptors., Bioorganic & medicinal chemistry, 8, (5), 2000Journal Article, 2000
  • Sasse, A, Stark, H, Reidemeister, S, Hüls, A, Elz, S, Ligneau, X, Ganellin, CR, Schwartz, JC, Schunack, W, Novel partial agonists for the histamine H(3) receptor with high in vitro and in vivo activity., Journal of medicinal chemistry, 42, (20), 1999Journal Article, 1999
  • Sasse, A, Kiec-Kononowicz, K, Stark, H, Motyl, M, Reidemeister, S, Ganellin, CR, Ligneau, X, Schwartz, JC, Schunack, W, Development of chiral N-alkylcarbamates as new leads for potent and selective H3-receptor antagonists: synthesis, capillary electrophoresis, and in vitro and oral in vivo activity., Journal of medicinal chemistry, 42, (4), 1999Journal Article, 1999, DOI
  • Weiss, C, Sametsky, E, Sasse, A, Spiess, J, Disterhoft, JF, Acute stress facilitates trace eyeblink conditioning in C57BL/6 male mice and increases the excitability of their CA1 pyramidal neurons., Learning & memory (Cold Spring Harbor, N.Y.), 12, (2), 2005, p138 - 143Journal Article, 2005, DOI , URL
  • Tezval, H, Jahn, O, Todorovic, C, Sasse, A, Eckart, K, Spiess, J, Cortagine, a specific agonist of corticotropin-releasing factor receptor subtype 1, is anxiogenic and antidepressive in the mouse model., Proceedings of the National Academy of Sciences of the United States of America, 101, (25), 2004, p9468 - 9473Journal Article, 2004, DOI , URL
  • Wang, J, Meng, J, Lawrence, GW, Zurawski, TH, Sasse, A, Bodeker, MO, Gilmore, MA, Fernández-Salas, E, Francis, J, Steward, LE, Aoki, KR, Dolly, JO, Novel chimeras of botulinum neurotoxins A and E unveil contributions from the binding, translocation, and protease domains to their functional characteristics., The Journal of biological chemistry, 283, (25), 2008, p16993 - 17002Journal Article, 2008, DOI , URL
  • Morisset, S, Sasse, A, Gbahou, F, Héron, A, Ligneau, X, Tardivel-Lacombe, J, Schwartz, JC, Arrang, JM, The rat H3 receptor: gene organization and multiple isoforms., Biochemical and biophysical research communications, 280, (1), 2001Journal Article, 2001, DOI
  • Multiple Steps in the Blockade of Exocytosis by Botulinum Neurotoxins in, editor(s)Jankovic, J., Albanese, A., Atassi, M.Z., Dolly, J.O., Hallett, M., Mayer N. , Botulinum Toxin - Therapeutic Clinical Practice and Science, Philadelphia, Saunders Elsevier, 2009, pp1 - 14, [Dolly, J.O., Meng, J., Wang, J., Lawrence, G.W., Boedeker, M., Zurawski, T.H., Sasse, A. ]Book Chapter, 2009
  • Meng, J, Ovsepian, SV, Wang, J, Pickering, M, Sasse, A, Aoki, KR, Lawrence, GW, Dolly, JO, Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential., The Journal of neuroscience : the official journal of the Society for Neuroscience, 29, (15), 2009, p4981 - 4992Journal Article, 2009, DOI , URL
  • Micallef, S., Quinn, E., Morris, D., Sasse, A., Genetic Polymorphism in Human Histamine 4 Receptor Gene and Schizophrenia, Society for Neuroscience Annual Meeting, Washington DC, USA, 12-16th Nov 2011, 2011, pp259Meeting Abstract, 2011
  • Micallef S, Stark H, Sasse A, Polymorphisms and genetic linkage of histamine receptors., Life sciences, 93, (15), 2013, p487-494Journal Article, 2013, DOI
  • Fabio Boylan, Astrid Sasse, Helen Sheridan(ed.), Holistic Approaches to Health Maintenance in the BSc. Pharmacy Degree at Trinity College, Institute of Technology, Dundalk, Ireland, 19-20th June 2013, 2013Proceedings of a Conference, 2013
  • Micallef, S, Quinn E, Morris, D, Sasse, A., MICROSATELLITE REPEAT EXPANSIONS IN HUMAN HISTAMINE(4) RECEPTOR GENE, Inflammation Reserach, 41st Annual Meeting of the European Histamine Research Society (EHRS), Belfast, Northern Ireland, UK, 2-5th May 2012, 61, (2), Springer, 2012, ppS52 - S52Meeting Abstract, 2012, DOI
  • Sasse, A., Histamine H4R Ligand Database, Inflammation Research, 42nd Annual Meeting of the European Histamine Reserach Society (EHRS), Lodz, Poland, 8-11th May 2013, 62, (1), Springer, 2013, ppS7 - S7Meeting Abstract, 2013, DOI
  • Niamh O'Boyle(ed.), 30th Annual GP2A Medicinal Chemistry Conference, Pharmaceuticals, Trinity College Dublin, Ireland, 16, (3), 24-26th August 2022, 2023, 432-Proceedings of a Conference, DOI , URL
  • The Histamine H3 Receptor: Gene Organization, Multiple Isoforms, Constitutive Activity and Molecular Pharmacology in, editor(s)Watanabe, T., Timmerman, H., Yanai, K. , Histamine Research in the New Millennium, Elsevier Science, 2001, pp9 - 21, [Arrang, J.-M., Morisset, S., Rouleau, A., Tarvidel-Lacombe, J., Gbahou, F., Ligneau, X., Héron, A., Sasse, A., Stark, H., Schunack, W., Ganellin, C.R., Schwartz, J.-C., ]Book Chapter
  • Partial Agonists for the Histamine H3 Receptor with High in Vivo Activity in, editor(s)Watanabe, T., Timmerman, H., Yanai, K. , Histamine Research in the New Millennium, Elsevier Science, 2001, pp77 - 82, [Schunack, W., Sasse, A., Stark, H., Elz, S., Ligneau, X., Ganellin, C.R., Schwartz, J.-C]Book Chapter

Research Expertise

  • Title
    Recent Advances in Histamine H4 Research
    Summary
    COST Action BM0806
    Funding Agency
    EU RTD Framework Programme
    Date From
    2009
    Date To
    2013
  • Title
    Identifying novel therapeutic targets for patients carrying single nucleotide polymorphisms in schizophrenia
    Summary
    Funding Agency
    European Social Fund (Malta)
    Date From
    April 2010
    Date To
    Aug 2013

Recognition

  • 1st Poster Price during the XXIXth Annual meeting of the European Histamine Research Society (EHRS) in Nemi/Rome 2000
  • Ernst-Reuter-Prize of the Free University of Berlin 2000
  • Carl-Wilhelm-Scheele-Prize of the German Pharmaceutical Society (DPhG) 2000
  • DPhG, Deutsche Pharmazeutische Gesellschaft (German Pharmaceutical Society)
  • PSI - Pharmaceutical Society of Ireland 2016
  • NI, Neuroscience Ireland
  • EUFEPS, European Federation for Pharmaceutical Sciences
  • FENS, Federation of European Neuroscience Societies
  • EHRS, European Histamine Research Society
  • SFN, Society for Neuroscience
  • Irish Representative, Management Committee of COST Action BM0806 'Recent Advances in Histamine Receptor H4R Research'. 2009
  • European Histamine Research Society (EHRS) Council Member 2012
  • Leader of Working Group 3 of COST Action BM0806 2011
  • European Histamine Research Society (EHRS) Council Member 2018 -
  • European Histamine Research Society (EHRS) Council Member 2018 -
  • Leader of Working Group 3 of COST Action BM0806 2011
  • Financial Rapporteur, COST Action BM0806 2011
  • Financial Rapporteur, COST Action BM0806 2011
  • Irish Representative, Management Committee of COST Action BM0806 'Recent Advances in Histamine Receptor H4R Research'. 2009
  • European Histamine Research Society (EHRS) Council Member 2012
  • Leader of Working Group 3 of COST Action BM0806 2011
  • European Histamine Research Society (EHRS) Council Member 2018 -
  • European Histamine Research Society (EHRS) Council Member 2012
  • Financial Rapporteur, COST Action BM0806 2011
  • Financial Rapporteur, COST Action BM0806 2011
  • Irish Representative, Management Committee of COST Action BM0806 'Recent Advances in Histamine Receptor H4R Research'. 2009
  • European Histamine Research Society (EHRS) Council Member 2012
  • Leader of Working Group 3 of COST Action BM0806 2011
  • Irish Representative, Management Committee of COST Action BM0806 'Recent Advances in Histamine Receptor H4R Research'. 2009
  • European Histamine Research Society (EHRS) Council Member 2018 -